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TNR Grand Rounds - Update on Biosimilars
This week's Tuesday Nite Rheumatology featured Dr Jonathan Kay (U Mass) who gave an update on Biosimilars and took questions the subject. The program was moderated by Dr. Jack Cush.
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#EULAR2020 OP0026. RITAZAREM. Rituximab superior to Aza 2mg/kg in maintaining remission in relapsing AAV. Flare rate 13% vs 38%. Note Ritux schedule is 1g every 4 months (x 5 infusions out to month 20).
Patrick Kiely pkiely500 ( View Tweet)
Can we treat GPA /ANCA vasculitis without steroids? Apparently yes +RCT by P Merkel in #EULAR2020 plenary adding avacopan-blocks C5a. Gutsy move as No steroids in one arm! ?cost effectiveness but a breakthrough @RheumNow @eular_org @CRASCRRheum https://t.co/kp7IZOaHfP
Janet Pope Janetbirdope ( View Tweet)
Dr. R Landewe highlights #EULAR2020 #COVID19 Guidelines:
1. RMD-patients do NOT have higher risk for complications 2. Rheumatologists SHOULD BE involved in management discussions 3. Potential shortages of sDMARDS and biologics
@rheumnow https://t.co/sjQubD7mJL
k dao KDAO2011 ( View Tweet)
Patients with RA-ILD vs RA only: More likely to be older, male, white and RF positive. More likely to have COPD, Rheumatoid nodules, erosions, extraarticular disease,⬆️antiCCP,⬆️ESR & ⬆️DAS28(CRP), DAS28(ESR), CDAI & SDAI scores #EULAR2020 #eular20 https://t.co/OhI9NKpStE
Mario Pompermayer, MD pompermarioMD ( View Tweet)
SAPHO or PsA with CASPAR criteria? 1/3 of SAPHO pts meet PsA criteria (particularly active or hx of psoriasis). Interestingly, most with osteitis did not meet CASPAR criteria while those with synovitis did. #EULAR2020 @RheumNow #AB0738 https://t.co/G4p6OiocE3
Dr. Rachel Tate uptoTate ( View Tweet)
Congratulations from all of us at the BRC to Professor Paul Emery OBE for being awarded a Meritorious Award at EULAR 2020 #EULAR2020goesvirtual #EULAR2020 #FightingRMDsTogether https://t.co/z9T4AZ5P0u
NIHR Leeds BRC LeedsBRC ( View Tweet)
Guselkumab improved axial symptoms, over 24 weeks in active PsA patients with radiographic sacroiliitis. Post-hoc analysis from Discover1&2 studies (Prof P Helliwell). #OP0054. #EULAR2020, >GF
ARD & RMD Open ARD_BMJ ( View Tweet)
Can fatigue in RA vary by bDMARD used? IL-6 inhibitor treatment associated with attaining a low fatigue state (RR 1.20 vs csDMARDs).
Given IL-6 secretion with HPA axis activation leads to fatigue/poor sleep, maybe something in this?
RABBIT database OP0020 #EULAR2020 @RheumNow https://t.co/wzFcqdUMMV
David Liew drdavidliew ( View Tweet)
17,500 people connected at moment at the largest e-Congress I could imagine #EULAR2020 #EULAR2020goesvirtual
Loreto Carmona 🖖 carmona_loreto ( View Tweet)
You've got at least two good reasons not to forget about cardiovascular risk in ankylosing spondylitis.
Traditional and inflammatory: it's the double whammy.
Mike Nurmohamed from @Reade_020 #EULAR2020 @RheumNow https://t.co/GLH7wzvrLN
David Liew drdavidliew ( View Tweet)
Use Of TNFi Before, During And The 1stY after Pregnancy Among Women With RA: Most of the women with RA were not treated with TNFi before or in pregnancy. Women w. RA that continue Rx with TNFi through pregnancy were using certilozumab and etanercept #EULAR2020 @RheumNow Abs0302 https://t.co/bWKrpx1hx7
Dr Philip Robinson philipcrobinson ( View Tweet)
Increased cardiovascular risk in:
- AS patients (adj HR 4.6 vs non-rheum controls)
- longer disease duration of inflammatory rheum disease (7% per year)
in a Spanish national multicentre project (CARMA) w 5y follow-up
Martin Martinez OP0002 #EULAR2020 @RheumNow https://t.co/BffbfPfkj0
David Liew drdavidliew ( View Tweet)
Consensus Statement: Use Of Jakinib Therapy In Immune Mediated Inflammatory Diseases: A consensus statement from @drpnash and others. Abstract AB0352. #EULAR2020 @RheumNow https://t.co/5uqwFoUglS https://t.co/fIZPWGHAPx
Links:
Dr Philip Robinson philipcrobinson ( View Tweet)
Certolizumab Pegol: A Safe And Efficient Treatment In Patients With Uveitis During Pregnancy: Conclusion: CZP seems to be effective and safe in female patients with uveitis during pregnancy and neonates. Abstract AB1055 #EULAR2020 @RheumNow https://t.co/MzeZKBawTg
Dr Philip Robinson philipcrobinson ( View Tweet)
Spinal Radiographic Progression in axSpA and the Impact Of Classification As non-radiographic Versus Radiographic Disease => Conclusion: Spinal structural damage is mainly restricted to patients with r-axSpA #OP0075 @XBaraliakos #EULAR2020 @RheumNow https://t.co/VYDwKfT44A https://t.co/G3kCN2ebzW
Links:
Dr Philip Robinson philipcrobinson ( View Tweet)
Population studies show #AS patients have a 36% increased risk of Cardiovascular mortality - most deaths being vascular disease relate #EULAR2020 https://t.co/H3CK81lEOb https://t.co/v6V5HlgRt1
Links:
Dr. John Cush RheumNow ( View Tweet)
46,311 #RA patients from the Swedish Rheumatology Quality Register were assessed for venous thromboembolism (VTE) risk. Increasing Dz activity increased the VTE risk #EULAR2020 OP0034 https://t.co/vEjKMMsT0U https://t.co/rzMMI9PlsV
Links:
Dr. John Cush RheumNow ( View Tweet)
Study of 21,525 RA patients in the Forward Databank finds 13.8% w/ lung disease (LD).RA-LD pts had more hospitalizations/deaths (HR 1.3) and 4 fold risk of resp-related events, not influenced by therapies. #EULAR2020 #OP0039 @RheumNow https://t.co/AgZcljDUDv https://t.co/Hl8Pc0YGnh
Links:
Dr. John Cush RheumNow ( View Tweet)
Case Controlled Study of 482 RA patients with ILD vs 741 RA w/o IL found an inverse relationship Between MTX exposure and ILD #EULAR2020 #OP0036 @RheumNow https://t.co/tfkBr0vyRP
Dr. John Cush RheumNow ( View Tweet)