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A Role for Netosis in COVID-19 Infection?

d Jack Cush, MD

Journal of Experimental Medicine has published a paper from a consortium of researchers at Cold Spring Harbor Laboratory, the Feinstein Institutes for Medical Research, and the Research Institute of the McGill University Health Centre (RI-MUHC) on the potential of neutrophil extracellula

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Tuesday Nite Rheumatology Grand Rounds - Febrile Disorders

d Jack Cush, MD

Dr. Jack Cush reviews the appproach to evaluating fever in adults suspected of having a rheumatic disease, Stills disease or autoinflammatory conditions.

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RheumNow Podcast – Drive Them Crazy (4.17.20)

d Jack Cush, MD

Dr. Jack Cush reviews the news, journal articles and new ACR COVID-19 guidelines from the past week on RheumNow.com.

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Physical Therapy Superior to Steroid Injection for Knee OA

d Jack Cush, MD

Treatment options for painful knee osteoarthritis (OA) are numerous, but comparative outcomes are seldom available. A NEJM report shows that physical therapy is superior to intraarticular glucocorticoids injections assessing the outcomes 12 months after the intervention. 

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COVID-19 Systemic Involvement

d Jack Cush, MD

The presentations of the COVID-19 infection have been clearly chronicled with the worrisome onset of sore throat, dry cough, loss of smell and taste with fevers, myalgias, fatigue and the worrisome progression of pulmonary involvement in a minority.  Lab findings may include a leukocytosis,

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NYU & Montreal Heart Instit. teaming on the COLCORONA study of Colchicine in early phase COVID-19 infx. TBD in 6,000 patients with mild forms of the disease. Dr. M Pillinger says colchicine, early on, may inhibit damaging inflammatory responses https://t.co/UTW2g6QU2r

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Dr. John Cush RheumNow ( View Tweet)

1st paper on the Global Rheumatology Alliance @rheum_covid registry published in Lancet Rheumatology. @ April 1st 110 COVID-19 Rheum pts enrolled from Europe, N&S America, Asia, Africa, Oceania; now up to 487 with 9894 in the patient survey. https://t.co/RI2AKsyf5T

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Dr. John Cush RheumNow ( View Tweet)

@LupusCanada has enhanced our survey to better understand the current situation and evolution of HcQ availability in Canada. Please share this survey with anyone impacted by this issue https://t.co/0ImHloC0JZ #LetsTalkLupus #LupusCanada #lupus

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Lupus Canada LupusCanada ( View Tweet)

Scary as hell ! The COVID-19 death rate in the USA doubles at least every 3 days..... https://t.co/u0UTLMf3NH

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Dr. John Cush RheumNow ( View Tweet)

Neurologic side effects of TNFi are rare; Sweden/Denmark population study shows TNFi in AS/PsA, but not in RA, associated with increased risk of neuroinflammatory events (0.59 to 0.87 /1000PY) with TNFi and 0.19-0.40/1000PY in unexposed https://t.co/FeRtKSspXj

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Dr. John Cush RheumNow ( View Tweet)

article in A&R details the Immunopathology, inflammatory mediators operative in cytokine storm syndrom of COVID-19 (and MAS/HLH), how to assess them and treatment options. Smart and timely article. (free read) https://t.co/3tsEVYMVRM

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Dr. John Cush RheumNow ( View Tweet)

Check out my take on the new ACR COVID-19 Guidance for Rheumatic Disease Patients - great suggestions; but I do have a few thoughts that differ....what do you think? https://t.co/8srDPYRo0b

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Dr. John Cush RheumNow ( View Tweet)

The RheumNow Podcast is up! Chikungunya, OI in kids, Dementia in RA, CPPD, COVID systemic dz and ACR COVID Guidelines; watch it here>> https://t.co/Y8Thiavero or listen to the podcast on iTunes or SoundCloud here>> https://t.co/G8ixVQCWG4

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Dr. John Cush RheumNow ( View Tweet)

Dr M Drazner ⁦@UTSWNews⁩ Grand Rounds on #COVID19 pts w/cardiac involvement may be afebrile ⁦@RheumNow⁩ https://t.co/nKUJe1HIdl

k dao KDAO2011 ( View Tweet)
Great image, from a review article found here: https://t.co/dTjrqclrvy https://t.co/SwKiCfyqEX

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Dr. John Cush RheumNow ( View Tweet)

Does Allopurinol lower mortality in gout? Metanalysis of 4 studies were split 2 yes, 2 no and overall all-cause mortality just missed significance with and adjusted HR 0.80 (95%CI (0.60, 1.05). https://t.co/sTB0Aq1lPd

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Dr. John Cush RheumNow ( View Tweet)

Wearing a face mask takes some getting used to. To get the most benefit, you need to avoid these common mistakes. https://t.co/MwLirqZdyN

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NYT Health NYTHealth ( View Tweet)

Chikungunya infection acutely shows fever, polyarthralgia, polyarthritis, HA, rash & GI Sxs; up to 60% develop chronic polyarthritis that mimics #RA. A retrospective report of 48 pts Rx w/ MTX (mean 9.2/wk) shows signif better pain and swollen joints. https://t.co/XEbvjSQOlx

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Dr. John Cush RheumNow ( View Tweet)

Sweets syndrome in NEJM: 54 yoM with UC has 3d of fever and abdominal pain after surgery, developed painful pustules and vessicles on neck and trunk w/ WBC 18k, ESR 40 and Bx w/ neutrophils and edema in the upper dermis. https://t.co/g1SDNS0CMS

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Dr. John Cush RheumNow ( View Tweet)

Henderson et al article in A&R details the Immunopathology, inflammatory mediators operative in cytokine storm syndrom of COVID-19 (and MAS/HLH), how to assess them and treatment options. Smart and timely article. (free read) https://t.co/3tsEVYMVRM

Links:

Dr. John Cush RheumNow ( View Tweet)

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