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RheumNow Podcast - Despite Corona (3.6.20)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

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Need for Disruptive Innovation in Rheumatology

d Jack Cush, MD

A full-read, novel Viewpoint article published in the Annals of Rheumatic Disease (Huizinga TWJ, et al) spotlights a recent international meeting of big thinkers, scientific collaborators and industry dedicated to innovation in rheumatology.

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Venom Peptide-Steroid Conjugate Effective in Collagen Induced Arthritis

d Jack Cush, MD

Science Translational Medicine features a report from the Fred Hutchinson Cancer Research Center showing that a scopion venom peptide, coupled to steroid, can significantly reduce joint inflammation in a rat model of rheumatoid arthritis (RA).

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1 year results of the ustekinumab in SLE trial encouraging. 1st 6 mos DBRPCT showed UST 62% vs PBO 33%. At wk 48 UST SRI4 responses maintained 63.3%; PBO crossovers caught up. 15% had seriour adverse events. https://t.co/XauG4JOJIj

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Korean National Health claims study shows there was a significant increased risk of incident #RA 6-7 weeks following respiratory viral infections (parainfluenza, coronavirus, metapneumovirus), most evident in women and elderly. https://t.co/njXTGzdj7r

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NEJM clinical case - 42-year-old man with cough and shortness of breath. Ex showed a saddle-nose deformity, CT showed destruction of the nasal bones with the formation of a large nasal cavity. Your Dx? https://t.co/DgLfFigntK

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"An appeaser is one who feeds a crocodile, hoping it will eat him last." - Winston Churchill

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FDA Requires Stronger Warning About Risk of Neuropsychiatric Events Associated with Asthma/Allergy Medication Singulair and Generic Montelukast. FDA review finds reports of \agitation, depression, sleeping problems, suicidal thoughts and actions. https://t.co/eJPVB3lS3s

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QD Clinic Compilation podcast from last week - hear about: Undertreatment, Involving the Dermatologist, the 7th DMARD, Hypermobility syndrome & Pred in Hand OA. Listen to the compilation (81-85) on iTunes or SoundCloud https://t.co/GNwt9ohHRe

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QD Clinic 85 - HOPE for Hand OA; Watch it here https://t.co/GNwt9ohHRe or listen to it on the podcaast https://t.co/xCwyYqx0sM

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News » RheumNow Podcast is up (3.6.20)! Reports on GCA, ANA in Liver Dz, Sleep apnea in RA, COPD causing RA, Aldolase in Still's, Venon as a vector. Watch it here>> https://t.co/znNXBkziBD or listen to the podcast on iTunes or SoundCloud >> https://t.co/fVPAoXYPgW

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Tocilizumab (Actemra) has been approved by the Chinese government to treat severe #coronavirus symptoms 👉🏽https://t.co/ETEQTga6GB #COVID2019 #COVID #CoronavirusOutbreak #Coronavid19 #covid19 #Covid_19 #CoronaAlert https://t.co/EoVGaYtkX4

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Dr Ai Lyn Tan DrAiLynTan ( View Tweet)
Check out the last 2 QD clinics on 7 DMARDs & counting and Kid Arthritis - on iTUNES or here >> https://t.co/4gDqvqHjnl and https://t.co/Lij5ot15gq

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Breast cancer pts taking Aromatase Inhibitors have higher Risk of Arthritis (13% vs 8.2%, p < 0.0001) & carpal tunnel (1.4% vs 0.8%, p 0.008). Taiwanese Claims Analysis of 2,055 women w/ breast cancer taking tamoxifen, anastrozole, letrozole, exemestane. https://t.co/K7IzqjN28M

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Fasting during Ramadan, 9th mo of Islamic calendar, with intermittent fasting (sunrise to sunset) shown to reduce Dz activity (compare pre/post fasting); 36 RA DAS 28 CRP decreased 4.3 to 3.5 (p < 0.001); 20 SpA pts 3.4  to 2.9 1.3 (p = 0.001). https://t.co/SI7jgXWz7w

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Small phase II pilot trial of Tocilizumab in JIA (n=22) associated uveitis failed to show efficacy - 34% (7/21) responded to treatment (p=0·11). https://t.co/2EoCfLcVOA

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"A fanatic is one who can't change his mind and won't change the subject" -Winston Churchill

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Risk factors for severe cranial ischaemic complications (sCIC) in GCA studied in 295 pts - 61 developed sCIC. Vision complications increased with age & jaw claudication (OR 3.43); decreased with PMR Sxs & higher CRP. Afib independent predictor of stroke. https://t.co/8VoZoVGVIp

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Study of 244 PsA &198 AS pts finds B27(+) in 25% PsA, 75% in AS. HLA‐B27 more likely to be younger, male, longer Dz duration, higher Xray scores. B27 was signif assoc w/ syndesmophyte symmetry, marginal syndesmophytes, but not sacroiliac symmetry. https://t.co/8MFVrTLWmF

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ANA positivity very common with liver diseases - 91% in syst autoimmune dz, 93% in PBC, 49% Autoimmune hepatitis, 19% in HBV, 14% in HCV, 23.5% in Hepatocellular carcinoma; but few had ANA ≥ 1:320 (5 HCC, 2.5%HBV, 1.6% HCV). Patterns also varied. https://t.co/1wnr9sHjye

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