RheumNow’s expanded coverage of the #ACR22 Annual meeting is sponsored in part by Novartis. All content chosen by RheumNow & its Faculty.

Curtis et al. Primary non-adherence to csDMARDs and b/tsDMARDs in RA/PsA/SpA. Medicare and commerically-insured patients. 20-44%! of new prescriptions not filled by 6 months. Higher for csDMARDs than b/tsDMARDs @RheumNow #ACR22 Abstr#2199 https://t.co/Pwg6GKu7Gg https://t.co/wPF0pu1UDa

• Primary Non-adherence to Biologics and Immunomodulatory Therapies for Rheumatoi…

Abstr #2192 risk of serious infxn in newborns of mothers on TNFi by placental transfer - % serious infection in TNFi in high vs low placental transfer (2.1% vs 1.6%) - HR (high vs low) 0.98 (95% CI 0.36-2.61) - No significant difference in risk of serious infxn @RheumNow #ACR22 https://t.co/7Lfpf7PERu

Which patients with IIM are high risk for #cancer? Abstract #0002 #ACR22 @RheumNow #ACRBest 📍Dermatomyositis 📍Anti-TIF-gamma, anti-NXP2 📍Age > 40y at dz onset 📍Dysphagia 📍Cutaneous necrosis 📍Persistent high dz despite immunosuppressive tx

Which is better for CV risk in RA: triple therapy DMARDs or TNFi? TARGET study n=159 using PET/CT surrogate (endpoint responsiveness👀) - either led to benefit - both equally good - benefit *not* linked to change in DAS28 A direct CV effect of RA Rx? ABST2215 #ACR22 @RheumNow https://t.co/4FPvSbfGsD

Vaccination +/- prior Covid-19, and with either mRNA or vectored DNA vaccines were not associated with AIRD flares. Negative association 21-days after 1st Covid-19 vaccination and no association after 2nd or 3rd doses. Nakafero G Abs#2194 https://t.co/vA8cMNQGkr #ACR22 @RheumNow https://t.co/SZnXejnmYt

• Is Vaccination Against Covid-19 Associated with Autoimmune Rheumatic Disease Fl…

Singh @NamrataRheum et al. Frailty in patients treated bDMARD/tsDMARD assoc serious infections aHR 1.34, any infection aHR 1.18, hospitalisation aHR 1.34 (all relative non-frail). @RheumNow #ACR22 Abstr#2218 https://t.co/ONsTBq8ehB https://t.co/iTVANh5flk

• Frailty Is Associated with Serious Infections in Biologic and Targeted-syntheti…

Thieves Market #ACR22 Ulcerative palatal lesions, non-spec bx +ANA 1:320 w other neg Abs Empiric steroids for presumed vasculitis New cavitary lung lesion. Pathology showed vasculitis Dacrocystitis w lobulated paranasal mass Dx: Extra nodal NK/T-cell lymphoma Fatal case @RheumNow https://t.co/TlDy9GfW7N

Flatman et al. Risk of infections in children with third trimester TNFi use, high vs low (CTZ, ETN) placental transfer. No difference but wide CIs, aHR 0.98 (0.36, 2.61) @RheumNow #ACR22 Abstr#2192 https://t.co/350UxX9bkL https://t.co/29uOtek8w7

• Serious Infections in Offspring Exposed During Late Pregnancy to Tumour Necrosi…

💤cognitive behavioural therapy 2 hours/wk for 6 wks for insomnia improves RA PROs at 26 wks Insomnia Severity Index -9.8 RAID -1.4 PGA -13 Small sample size wk6 trend improvement sleep efficiency 89% vs84% p=0.07 but not wk26 https://t.co/rpKdtbREYs Abs#2188 #ACR22 @RheumNow https://t.co/kEBcPAdIKW

• The Effect of Group-based Cognitive Behavioral Therapy for Insomnia in People w…

Interesting Abs 1997 finds butyrate supplementation in RA assoc'd w/changes in human gut microbiota composition and in peripheral Treg abundance and markers of Treg activation. More data needed to determine clinical/dz activity relevence. #ACR22 @RheumNow https://t.co/tQocYUU0Er

• Effects of Short Chain Fatty Acid Supplementation in Modulation of Gut Microbio…

#PregnantWoman with #sle - n = 873 Highest overall adverse events in Preexisting HTN complicated by race We have a Modifiable risk factor - HTN to work closely abst#2107 @rheumnow #ACR22 #ACRBest https://t.co/EC8c7Dzrvs https://t.co/Jydz0uo1bv

• Pregnancy Outcomes Among Women with Systemic Lupus Erythematosus (SLE): Impact …

Interosseous tendon inflammation (ITI) the new predictor of clinical RA in pts w/ clinically suspect arthralgia. 600+ pts Hands MRI Present 10% pts w/ CSA, 1% symptom free 27% ACPA+ 7% ACPA- HR 4.5 dvlpmt of clinical RA https://t.co/BmRF1tLFx9 Abs#2204 #ACR22 @RheumNow https://t.co/F8DUxiI2dh

• Interosseous Tendon Inflammation in the Hands: A Novel Feature of Developing Rh…