Are your SpA pts planning on conceiving? Be careful with NSAID use French study found age and NSAID use associated with longer time-to-conception. Factors not associated: smoking, BASDAI score, DMARD use #ACRBest Abs#1673 @RheumNow #ACR22 https://t.co/D63XTY7IB8

Ab1673 #ACR22: Time-to-Conception (T2C) in SpA Prosp, observ 88F, 56 pregnancy Subfertility in 45% F, T2C 16 mos Risks: age, NSAID Rx: NSAIDs (26%), steroids (9%), csDMARD (14%), biol (69%) No control grp - Is it cause or correlate? 2020 Repro G/L rec d/c NSAID @RheumNow #ACRBest https://t.co/e51XjhyH9u

☝️Treatment is the 3rd reason why we need to order a BL HRCT in pts with ILD; "We can't treat SSc-ILD if we are not able to detect SSc-ILD" - Dr. Elana Bernstein #ACR @RheumNow #rheumatology https://t.co/ooZVSbt3Xf

Peresolimab humanized IgG1 mab ➢ stimulates PD-1 & physiological immune inhibitory pathways ➢ In RA phase 2 study, superior to placebo at Week 12 DAS28/CDAI ➢ safety events were similar between treatment groups Emery P #L03 https://t.co/4Jd79CW5RA #ACR22 #ACRBest @RheumNow https://t.co/PSuLQgjYuz

• A Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis - ACR Meeti…

BE OPTIMAL Study - Bimekizumab (IL-17A and IL-17F inhibitor) for treatment of PsA. Similar ACR 50 (~50%) response rates of Bimekizumab, adalimumab, and placebo (switched to BKZ at wk 16). ~60% PASI100 in BKZ #ACRBest Abs#L02 @RheumNow #ACR22 https://t.co/W2B2kyju9F

Hamroun et al. Preconceptual NSAID use assoc impaired fertility in SpA, HR 3.01 for time-to-conception @RheumNow #ACR22 Abstr#1673 https://t.co/jresR9MfXF https://t.co/flyfJob9un

• Preconceptional NSAID Treatment Exposure Is Associated with a Significantly Lon…

Congratulations @RheumNow @rheum_cat @CreakyJoints 🎉 #ACR22 https://t.co/P7iLUPnt0p

• https://twitter.com/stevenechard/status/1592184317056544768

Ab1674 #ACR22 HCQ in pregnancy is SAFE and Standard of Care! In Utero Exposure to HCQ does NOT ass w/ ocular toxicity: OCTs 5 yrs after birth 👀 PATCH study of HCQ to reduce CHB in pregnancy 18% CHB (historical) -> 7% treated risk OCT: retinal thickness nml at 5 yrs @RheumNow

#CurbsideConsult. What would you do? 45 yo female with dSSc and ILD, had been on stable MMF 1500 mg bid. she had increased SOB, new dry cough, hand pain, stiffness.Exam noted synovitis, Labs: ESR 76, Echo RSVP 25 mmHg, HRCT increased ILD compared to a year ago. #ACR22 @rheumnow

Are TNFi or IL-6Ri safe in rheumatic irAEs from ICI Rx? Multiple big US centers retrospective: TNFi, IL-6Ri vs MTX p>0.05, but may be approx 2x risk of cancer progression Has made me more cautious about TNFi, IL-6Ri - use MTX when you can Lovely work! ABST1669 #ACR22 @RheumNow https://t.co/cfAT1pQZ7I

This is how Dr. Berstein manages SSc-ILD #ACR22 @rheumnow #CurbsideConsult https://t.co/vP7m0WpdK6

Abdel-Wahab et al. TCZ in combo with ipilimumab/nivolumab. Very preliminary results of what will be important trial. Appears safe and well-tolerated with no increased risk cancer progression. @RheumNow #ACR22 Abstr#1670 https://t.co/uPBnHJ9BRH

• Phase II Clinical Trial to Assess the Safety and Efficacy of Tocilizumab in Com…

Messier et al. WE-CAN pragmatic trial of diet and exercise (vs attention control) in knee OA with high BMI. Significant improvement in pain, walk distance, SF-36 with corresponding reduction in body weight @RheumNow #ACR22 Abstr#1675 https://t.co/uSSzx4u2sp https://t.co/upnIVecRjv

• Effectiveness of Intensive Diet and Exercise on Knee Pain Among Communities wit…

SAPHYR results: SAR + 14 wk GC taper showed efficacy vs comparator arm in steroid refractory PMR, including clinically meaningful improvement in QoL. No new safety signals. Plenary Abs 1676 #ACR22 @RheumNow https://t.co/mHu3e9JbCp https://t.co/93kbczSTfS

• Sarilumab in Patients with Relapsing Polymyalgia Rheumatica: A Phase 3, Multice…

Tonight at 7pm ET! Join our RA Topic Panel with panelists: Drs. Richard Conway, Aurelie Najm, David Liew, Janet Pope, Julian Segan @RichardPAConway @AurelieRheumo @drdavidliew @Janetbirdope @JulianSegan #ACR22 https://t.co/hIH4WghLwN https://t.co/oKQbBnMiqQ

• https://bit.ly/3UCVGqK