Dr. Rachel Tate uptoTate
3 years 11 months ago
Initial Remibrutinib (oral, covalent, and highly specific inhibitor of Bruton’s tyrosine kinase (BTK)) data in SS shows good efficacy and safety. Plenary Abs 1113 #ACR22 @RheumNow https://t.co/5Zr0Y1ueAv https://t.co/Iy194YUWNC
Dr. John Cush RheumNow
3 years 11 months ago
RheumNow’s expanded coverage of the #ACR22 annual meeting is sponsored in part by Novartis. All content chosen by RheumNow & its Faculty.
Aurelie Najm AurelieRheumo
3 years 11 months ago
DANBIO registry: 1600+ pts RA, AxSpA, PsA
Infiximab biosimilar to biosimilar switch (CT-P13 -> GP1111)
Maintenance at 1yr:
>80%
> withdrawal in original IFX naive, but higher BL DA
Do second time switchers do better because of past switch experience?
Abs#1112 #ACR22 @RheumNow https://t.co/IgjhGLVESz
Robert B Chao, MD doctorRBC
3 years 11 months ago
2nd Plenary Session!
Remibrutinib (BTK inhibitor) for treatment of Sjögren's syndrome (phase 2 study)
Improvement of ESSDAI, salivary flow and pathologically elevated Ig's
Abs#1113 @RheumNow #ACR22 https://t.co/vdgxBPe6qd
David Liew drdavidliew
3 years 11 months ago
We're used to originator-to-biosimilar switches.
Widespread biosim use means we now see biosim-biosim switches (incl as second switch)
DANBIO data
retention good
I see the hallmarks of nocebo still an issue
I think we can all agree: ongoing education important
#ACR22 @RheumNow https://t.co/6PcMfEEozk
Aurelie Najm AurelieRheumo
3 years 11 months ago
Yes. But this only accounts for 1/3 of risk to develop clinical RA.
We need a better understanding of the other 2/3 so we can propose efficient preventive interventions.
#ACR22 @RheumNow https://t.co/RRzlAISFK3
Fabio Torres FabioTorressav
3 years 11 months ago
@EBRheum @RheumNow Its more than that…tubulointerstitial kidney disease, lymph nodes, salivary gland, and hepatobiliary tract disease don’t show findings of vasculitis.
Certain HLA haplotypes more linked with autoimmune diseases are present.
#ACR
@RheumNow
Dr. Rachel Tate uptoTate
3 years 11 months ago
@AlexisOgdie et al: PsA pts who were MDA, DAPSA LDA, or ACR50 responders vs non-responders reported clinically meaningful improvements across PROs including pain, physical function, fatigue, and work productivity. Abs 1019 #ACR22 @RheumNow https://t.co/MK13sXS3Or https://t.co/TfCrQMV2JX
Dr. Rachel Tate uptoTate
3 years 11 months ago
Presence of DFS pattern should not be used to indiscriminately exclude presence of a rheumatic disease based on retrospective study in Abs 0814. RA, SS and Raynaud's ICD10 codes were higher among DFS pattern ANA per chart review. #ACR22 @RheumNow https://t.co/mLtppvR4dk https://t.co/6Lukxntqe7
Robert B Chao, MD doctorRBC
3 years 11 months ago
Biosimilar to biosimilar effective in treatment of RA/PsA/AxSpA.
Large study looking at infliximab biosimilar switching - resulted in high retention rates and virtually no change in disease activity.
@RheumNow #ACR22 Abs#1112 https://t.co/uNRXLewo4M
Dr. Rachel Tate uptoTate
3 years 11 months ago
The greater the PsAID score, the more likely escalation in PsA treatment. Noted significant correlation between PsAID and physician global scores. Do you use PsAID in your clinic? Abs 1028 #ACR22 @RheumNow https://t.co/gcjm2XgPE3 https://t.co/bKPtXz5Nw8
Akhil Sood MD AkhilSoodMD
3 years 11 months ago
Abstr #1494 determinants of clinically important worsening (CIW) of early axSpA
- CIW = ASDAS ↑ > 0.9 b/w 2 visits
- Tender Joint count and ASAS-NSAID score associated w/ CIW
- MRI SI Jt inflammation & structural damage predictive of CIW
@RheumNow #ACR22 https://t.co/Dgeh25BaWM
David Liew drdavidliew
3 years 11 months ago
Global survey of rheumatic irAE people (me included)
Standard case
Variable answers, broadly distributed
none are wrong
We'll move from expert extrapolation of concepts to data-driven answers, with the right foundations👍
ABST0776 @MDAndersonNews @msalmazor #ACR22 @RheumNow https://t.co/5gMzWuCXd7
Catherine Sims, MD DrCassySims
3 years 11 months ago
Do patients with PsA like online wellness programs? #ACR22 @RheumNow
🌈 186 patients, 86% women, 90% White
🌈sleep and nutrition were highly rated for wellness
🌈cost and fatigue barriers to adopting wellness behaviors
🌈 27% were open to an online wellness program
Dr. Rachel Tate uptoTate
3 years 11 months ago
BASDAI and ASDAS performed similarly in axPsA pts, both demonstrating weak correlations w/ peripheral arthritis and moderate/strong correlations w/ pt fatigue and pain. Abs 1037 #ACR22 @RheumNow https://t.co/WRQx1hkIll https://t.co/kJVIWyVv2w

