Dallas Heart Study: at least 1 aPL detected in 15% of adults from the general population. IgA isotypes of aCL & aβ2GPI independently assoc'd w/ future ASCVD events, and aβ2GPI IgA demonstrated increased risk of atherothrombosis. Abs 0681 #ACR22 @RheumNow https://t.co/m9XUTz2S5e https://t.co/vCXLJdBg70

• Antiphospholipid Antibodies and Incident Cardiovascular Events in a Diverse Pop…

We know depression, anxiety are issues for many RA pts. Are we making the diagnosis more? Olmsted County data: depression similar over time anxiety 3x more common in 2005-2014 vs 1985-1994 (adj age/sex +/- others) How do we address this? ABST0886 @MayoClinic #ACR22 @RheumNow https://t.co/tzMEE24FZo

Molina et al. Dupilumab (IL4/IL13 mab) in refractory EGPA. Complete response 49%, partial 43%. But flares in 27%. Dupilumab-induced eosinophilia in 57%. @RheumNow #ACR22 Abstr#1074 https://t.co/cziyHNPN3j https://t.co/h7gWAShQeL

• Safety and Efficacy of Dupilumab in Patients with Relapsing and/or Refractory E…

Zuo @jasonsknight et al. Dallas Heart Study. aPL and incident CV events. IgA isotypes of aCLand aβ2GPI were independently associated with future ASCVD events. @rheumnow #ACR22 Abstr#0681 https://t.co/C7O4rnFZCG https://t.co/1H7uiPUwuv

• Antiphospholipid Antibodies and Incident Cardiovascular Events in a Diverse Pop…

Abs 0674 finds that HIT is rare among hospitalized APS and SLE patients with aPL and that anti-PF4 antibodies are often inappropriately tested in this population. #ACR22 @RheumNow https://t.co/hFZzpuEkDG https://t.co/hyUYVZLUM4

• Prevalence of Heparin Induced Thrombocytopenia in Hospitalized Patients with An…

🔥 VEXAS + the 🫁 🔥 🔑 Points ~ 🫁 involvement common 👉cough + dyspnea 🌬PFTS often normal 🩻 CXR useful but HRCT superior 🩻ground glass opacity commonest finding 💊 good response GC 🔥ignite session🔥 #ACR22 Abst# 1569 @RheumNow

Abs 0345 finds association between cumulated HCQ and development of cardiac abnormalities. We need further data to determine clinical association. #ACR22 @RheumNow https://t.co/WmixbFIlfd https://t.co/2Ejwkeu1Az

• Association Between Cumulated Hydroxychloroquine in Systemic Lupus Erythematosu…

In the absence of other high risk factor for thrombosis, Thrombocytopenia (ITP) could be an independent and long-lasting clinical phenotype for aPLs carriers. Abs 0672 #ACR22 @RheumNow https://t.co/LmlruGqkEJ https://t.co/MaIHS0QWN0

• Immune Thrombocytopenia Could Be an Independent Phenotype of Primary Antiphosph…

Sometimes we guess how RA pts will be, before they come in. machine learning to predict RA dx activity: RISE registry (n=39,155) inputs: prev CDAI, demo, smoking/obesity, SES v good performance Past performance does predict future outcomes, sometimes! ABST0905 #ACR22 @RheumNow https://t.co/Ir1YG1cqlD

Kajiyama et al. JAKi counteract cellular toxicity of HCQ in vitro. Could they prevent HCQ-retinopathy? @rheumnow #ACR22 Abstr#0653 https://t.co/c0a4OYCzw5 https://t.co/X7pFM7j1R4

• JAK Inhibitors Counteract Cellular Toxicity of Hydroxychloroquine in Vitro - AC…

RheumNow’s expanded coverage of the #ACR22 meeting is sponsored in part by Bristol-Myers Squibb. All content chosen by RheumNow & its Faculty

Park et al. Risk-benefit of PJP propylaxis in rituximab treated patients. NNH 86 . NNT - all RTX 146, RTX+high dose steroid 21. This mirrors my practice @RheumNow #ACR22 Abstr#0720 https://t.co/JPtPCqah9R https://t.co/bonRzWFbVw

• Risk-Benefit Assessment of Primary Prophylaxis for Pneumocystis Pneumonia in Pa…

Kaneko et al. Tocilizumab leads to significantly lower steroid doses in Adult onset Stills Disease @RheumNow #ACR22 Abstr#0826 https://t.co/jc1S6sdfkm https://t.co/z0cHB4wYu6

• Treatment Pattern and Changes in Oral Glucocorticoid Dose After Tocilizumab Tre…

What neonatal factors could affect development into axSpA? Turns out antibiotic exposure (6.2x more likely). Mode of delivery, early diet (milk vs. formula), maternal smoking (!!) did not show association. @RheumNow #ACR22 Abs#0868 #ACRBest https://t.co/roCAj5YsCt

In non-renal SLE, BEL associated w/ a lower risk of severe infection and hospitalizations due to severe infection compared to MTX, AZA, MMF. Abs 0349 #ACR22 @RheumNow https://t.co/0EBpCMPOqF https://t.co/vdxKVJSaZA

• Comparative Risks of Infection with Belimumab versus Oral Immunosuppressants in…