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Anakinra in Pericarditis: A Systematic Review (comprehensive, full read) -Options include steroids, colchicine, NSAIDs,

Dr. John Cush RheumNow

3 years 11 months ago

Anakinra in Pericarditis: A Systematic Review (comprehensive, full read) -Options include steroids, colchicine, NSAIDs, pleuropericardial window, IL-1 inhibitors. ANAKINRA - 11 studies, 259 pts, all showing significant rapid resolution. https://t.co/rcnTPkDTjq https://t.co/RbW1fPSjfU

Hydroxychloroquine Dosing and SLE Flares

A cohort study examining HCQ dosing in patients with SLE suggests that HCQ do

Dr. John Cush RheumNow

3 years 11 months ago
Hydroxychloroquine Dosing and SLE Flares A cohort study examining HCQ dosing in patients with SLE suggests that HCQ doses of 5 mg/kg per day or less, was associated with a higher risk of lupus flares, including moderate or severe lupus flares. https://t.co/UeIZ70zRnt https://t.co/tGrBSydvKB
Long COVID study (54 studies, 2 databases, 1.2 million pts) showed at least 1 in 3 reported Long COVID Sx clusters (fati

Dr. John Cush RheumNow

3 years 11 months ago
Long COVID study (54 studies, 2 databases, 1.2 million pts) showed at least 1 in 3 reported Long COVID Sx clusters (fatigue, bodily pain, mood swings, cognitive or resp Sxs), more common in women <20 yrs, w/ duration 9 mos in Hosp pts https://t.co/vuJrpWizzr https://t.co/e58J8rctEC
Spinal cord stimulation is a $2-3billion market, despite limited efficacy. A placebo controlled trial of spinal cord bur

Dr. John Cush RheumNow

3 years 11 months ago
Spinal cord stimulation is a $2-3billion market, despite limited efficacy. A placebo controlled trial of spinal cord burst stimulation, in 50 pts w/ chr radicular pain after lumbar surgery, showed no significant benefit in back pain–related disability. https://t.co/aRN5sRbqFx https://t.co/A37LWaYEGw
Pregnancy in systemic lupus erythematosus (SLE) is fraught with problems of adverse pregnancy outcomes, more pregnancy loss and birth defects. Now a study of SLE pregnancies exposed to belimumab (BEL) shows and expected rate of pregnancy loss but a variable rate of birth defects. Data were derived from the BEL clinical trials, the Belimumab Pregnancy Registry (BPR), and postmarketing/ spontaneous reports up to 8 March 2020.
Prevotella Immune Response in Both Pre-Clinical & Established RA
  • EurekAlert! and Jack Cush
In a recent analysis published in Arthritis & Rheumatology, people at risk for rheumatoid arthritis (RA) and those with the disease had elevated blood levels of antibodies against a Prevotella copri (Pc). 
Dr. Kent Kwoh and Researchers at the University of Arizona Arthritis Center have been awarded a $3.4 million grant from

Dr. John Cush RheumNow

3 years 11 months ago
Dr. Kent Kwoh and Researchers at the University of Arizona Arthritis Center have been awarded a $3.4 million grant from the National Institutes of Health to undertake a study that seeks to identify determinants of rapid knee deterioration in OA https://t.co/EodUXk6FDp https://t.co/bX2k5c7lR9
NEJM: Dysphagia Due to Diffuse Idiopathic Skeletal Hyperostosis - 70yoM with 6-month history of dysphagia. Compression o

Dr. John Cush RheumNow

3 years 11 months ago
NEJM: Dysphagia Due to Diffuse Idiopathic Skeletal Hyperostosis - 70yoM with 6-month history of dysphagia. Compression of the hypopharyx by large cervical osteophytes was seen in a videofluoroscopic swallowing study https://t.co/AVDXPzhfjd https://t.co/7TwY0CGaxb
Cross-sectional study of 291 PCPs shows that increased electronic health record (EHR) time was associated with a signifi

Dr. John Cush RheumNow

3 years 11 months ago
Cross-sectional study of 291 PCPs shows that increased electronic health record (EHR) time was associated with a significantly greater liklihood of meeting patient target goals for Hgb-A1C, HTN control and breast cancer screening https://t.co/mLdoHM9N7O https://t.co/li6QD5jq7F
Arthritis Clinical Trials Comparison Grid
Use this resource to keep track of your clinical trials and key information n

Dr. John Cush RheumNow

3 years 11 months ago
Arthritis Clinical Trials Comparison Grid Use this resource to keep track of your clinical trials and key information needed when communicating with patients about a drug study. https://t.co/9z42zfr1Fx https://t.co/dYAjOVvTaW
Miners Face Increased Risk of Rheumatoid Arthritis
  • MedPage Today
Add "hard rock" mining to the list of occupations associated with high rates of rheumatoid arthritis (RA), a new study indicated, with silica exposure the presumed malefactor.
CRTAC1- a Novel Biomarker for Osteoarthritis
  • EurekAlert!
Scientists at deCODE genetics a subsidiary of Amgen report in Arthritis & Rheumatology that a novel plasma protein (cartilage acidic protein-1; CRTAC1) is a potential biomarker of osteoarthritis (OA) through its association with OA risk and progression to joint replacement.
EMA CHMP issued a positive opinion on the safety of Filgotinib, a selective JAK1 inhibitor, based on testicular safety d

Dr. John Cush RheumNow

3 years 11 months ago
EMA CHMP issued a positive opinion on the safety of Filgotinib, a selective JAK1 inhibitor, based on testicular safety data from the MANTA & MANTA-RAy studies. Gilead withdrew filgotinib from US market w/ FDA concerns on testicular safety in 12/20 https://t.co/38xOWb1zJi https://t.co/jPUy6H1QQN
Urine proteomics on 54 SLE pts in the Belimumab–Lupus Nephritis trial, compared responders (n 31) v non-responders (n

Dr. John Cush RheumNow

3 years 11 months ago
Urine proteomics on 54 SLE pts in the Belimumab–Lupus Nephritis trial, compared responders (n 31) v non-responders (n 22), on BEL or SOC. Reduction in urinary CD163 was strongly associated with complete renal response @wk52 & CD23 @wk24 https://t.co/PrXaJq6h0E https://t.co/IWREF9VmZ8
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