GALAXI-1 Study - Guselkumab effective in Crohn's Disease. 309 CD pts (1/2 refractory dz) Rx w/ either PBO, or IV GUS 200 mg, 600 mg, or 1200 mg at weeks 0, 4, and 8; At week 12, all 3 doses had signif. clinical and endoscopic improvements vs PBO https://t.co/iGyAmCoO96

• https://bit.ly/3FmLrQi

RBCs from SLE patients retain mitochondrial proteins that may either lead to type I IFN or be taken up by myeloid cells. (V. Pascual) #UTSWSLE2022 https://t.co/VdQGRDUMvX

Dr. Pascual shows that signatures show IFN or plasmablast or PMN/Myeloid signatures, thus identifying 7 subsets of lupus kids #UTSWSLE2022 https://t.co/3BAxPdAKw8

DOCTORS: are you ready to attend big medical meetings ? @LCalabreseDO

Clinical evidence of type I IFNa excess expressed in clinical SLE (Dr. Virginia Pascual) #UTSWSLE2022 https://t.co/To2U9ZtxU3

Professor Chandra Mohan on pathogenesis and immunogenetics of #SLE - over 180 genes linked to the pathogenesis, modified by infection (bigger role for EBV?) hormones, smoking, hormonal status. #UTSWSLE2022 https://t.co/aKNpxZfdc6

Efficacy of Subsequent b/tsDMARD Use in Rheumatoid Arthritis https://t.co/5dXe0AdNzE https://t.co/eS4KdaKBmC

• https://bit.ly/3L5Hl0t

Three (3) Worst Drugs to use in #Lupus patients who want to be pregnant (MTX, MMF, CTX) #UTSWSLE2022 https://t.co/YBeLTuRLO1

Algorithmic approach to SLE and assessing/treating early pregnancy. #UTSWSLE2022 https://t.co/692el4R9sZ

Adverse pregnancy outcomes and Risks in #SLE. (Dr. Eliza Chakravarty - OMRF) #UTSWSLE2022 https://t.co/HqscJD2m96

Long acting reversible contraceptives (LARC) are recommended in #SLE. #UTSWSLE2022 https://t.co/oFyNTHzVAj

Nearly 40% of all #SLE pregnancies are unplanned - hence, contraception (unused in 73%) and education are paramount in management of women w/ SLE. (Dr. Lisa Sammaritano- HSS) #UTSWSLE2022 https://t.co/ooryrW9GGn

An increasing incidence of RA is driven by increasing # of ACPA-negative RA (but not ACPA-positive RA), partly explained by an ageing population (thus making ACPA-negative RA more prevalent in coming years) https://t.co/9vC8aCphKc

• https://bit.ly/383ZAWF

"I think we can get rid of maintenance prednisone in nonrenal lupus" (but not in renal lupus) "...prednisone contributes to some organ damage (but not renal)" Organ damage is multifactorial -traditional risk factors, disease activity & steroids - Dr. Michelle Petri #UTSWSLE2022 https://t.co/N9NMPgtPEn

"How awful is our current prednisone practice" - Dr. Michele Petri #UTSWSLE2022 https://t.co/WGNx5yxF8x