Cell has a novel analysis using single-cell analysis of skin/blood from 56 controls & 97 diffuse systemic sclerosis pts, finding stromal abnormalities in LGR5+-scleroderma-assoc fibroblasts (ScAFs). ScAFs are decreased early & progressively https://t.co/Khxejd1fnq https://t.co/OrMAJnPTZt

• https://bit.ly/3E0ngGS

ArthritisPower study of 332 #PsA pts finds patients are most bothered by joint pain, MSK pain & fatigue. Patients prefer oral, QD meds; 3/4 want Rx that improved joints vs skin; and would prefer to avoid MTX https://t.co/WYqWgoimOT https://t.co/RgGeCKrpT1

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2020 Pt preferences survey- 137 #PsA pts most took TNFi (30%), IL-17i (20%), MTX (10%). From 2018 to 2020 a signif incr in IL-17i & PDE4 inhib. Pts want Rx for damage (80%), ADL (71%), & pain (70%) https://t.co/2dyIuQubh5 https://t.co/sFbtRj0Lbv

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ICYMI: Deucravacitinib, TYK2 inhib, studied in phase II trial 203 active PsA pts randomised to PBO, or DEUC 6 mg or 12 mg qd. At wk 16 ACR-20 responses were significantly higher with DEUC 6mg (53%, p=0.0134) and 12 mg (63%, p=0.0004) vs PBO. https://t.co/UOPteZY0g8 https://t.co/Xw3ZSPWeE0

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ICYMI: Differences between Palpated & Ultrasound Joint exams in 155 #PSA patients. 5616 joints - found 18.5% tender, 9.8% swollen, 20.4% w/ US GS ≥ 2 and 5.2% had US PD ≥ 1. Joints that were both tender and swollen more likely to have GS ≥ (44%) https://t.co/M6y5Gezhjs https://t.co/HYoI3pExRm

• https://bit.ly/3xciWmv

ICYMI:The Enthesitis Challenge in Psoriatic Arthritis A colleague of mine told me an interesting story about how her father, who was a doctor, misdiagnosed his wife with fibromyalgia when she actually had PsA with enthesitis all along. Read more... https://t.co/bSYdtlL41J https://t.co/gKKdWTvyMB

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ICYMI: TNR Recap: What Patients Say About PsA Watch Tuesday Nite Rheumatology, held on 4/5/22,which featured a Patient Perspectives panel discussion, hosted by Dr. Jack Cush. PsA Panelists included: - Tena Brown - Christine Lindsay - Ashley Krivohlavek https://t.co/FyjnzrtKqp https://t.co/uEHsoAwHLY

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ICYMI: Dactylitis Indicates a Severe PsA Phenotype https://t.co/7VVoc0f1Ap https://t.co/uZxfqLvtcp

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ICYMI: 520 RA pts were screened with FibroScan (liver fibrosis)- F3 or F4 liver fibrosis seen 13.3% of controls vs 12.7% arthritis pts. MTX was not significantly correlated w/ higher FS scores. Liver stiffness was correlated w/ BMI, waist, male , age. https://t.co/PxrabHROPy https://t.co/UAw51Hb5vU

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Humbled to lecture at the #StaabSymposium with rheum greats @RheumNow and @KeithReich3 https://t.co/RHM1oneIc3

What I learned... always get an ALP and phosphorus level in people with chronic bony pain. https://t.co/nE0xYwODmC

• UTSWRheum on Twitter: "Dr. N Maalouf summarizes #hypophosphatemia for rheu…

Useful TST (PPD)/IGRA interpreter website for TB testing. A 31 yoM Texan w/ +IGRA only (true pos) has risk of active TB & INH hepatitis 0.1% & 0.4%. But if this was 60 yoF from Iraq on TNFi & pred the same risks are 20% & 2.3% https://t.co/M18cHuLrXu https://t.co/zIoFY4abXN

• https://www.tstin3d.com/en/calc.html

ICYMI: Metanlysis of psychological interventions for chronic low back pain (97 RCTs, 13,136 pts) finds that Only behavioural therapy delivered w/ physiotherapy care (mainly structured exercise) reduced pain intensity up (high quality evidence) https://t.co/56pMRVk0ic https://t.co/wxcfninf14

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ICYMI: Review of 5 trials shows ixekizumab with higher rates of complete skin & nail clearance compared H2H against to etanercept, guselkumab, ustekinumab, and adalimumab (Data from IXORA-R, IXORA-S, UNCOVER-2, UNCOVER-3, & SPIRIT-H2H trials https://t.co/t5wrmE3nbK #PsA #PsAlways https://t.co/MQjgktOZWR

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