Excited for the first full day of #ACR21, reporting for @RheumNow! Esp looking forward to: ⭐Posters: #Epidemiology, #PublicHealth, #COVID19, #SpA, #RheumatoidArthritis, #PatientOutcomes ⭐Plenary session ⭐Scientific sessions covering #axSpA, #PsA and more

How much ritux for AAV maintenance? Ever since we started using it, no-one's been sure. If absolute B cell depletion is your goal, @VUMCRheum data suggest >3.3mg/d is safest for that 500mg q6m = 2.7 mg/d 500mg q4m = 4.1 mg/d 1000mg q6m = 5.5mg/d #ACR21 ABST0416 @RheumNow https://t.co/mYAgKhHT7j

Dr. Chambers review @MotherToBaby prospective data on HCQ use in pregnancy (n=279): 👉no major defects (regardless of dose) 👉no oral clefts 👉SGA slightly lower in exposed group b/c of underlying dz 👉no case of retinopathy in babies after 1 year f/u @rheumnow #Pregnancy https://t.co/vw2eryFgro

Abst#271 #ACR21. RA activity predicts left ventricular mass change in pts without CVD ⭐️35% had abnormal LV geometry at baseline TTE ⭐️55% at f/u TTE 3-6 years later ⭐️Increase in concentric remodeling on LV @Rheumnow https://t.co/uHnqITcTy9 https://t.co/KmV8volVwd

• https://bit.ly/3GPu2A6

@DrDDRheum presents on uveitis in SpA. AxSpA>PsA, 30% vs 7.6%. PsA: B27+⬆️ risk, smoking ⁉️ and DMARDs protective. AxSpA: Elevated CRP⬆️ risk, biologics protective. Abstr#0064 #ACR21 @RheumNow https://t.co/psw20RGDst

Dr. Chambers reviewed @MotherToBaby data of pregnant rheum women during the pandemic noted: ⬆️EtOH use in pregnancy, ⬆️stress, anxiety, depression ⬆️obesity ⬇️likelihood to get prenatal care #ACR21 @rheumnow #RheumPregnancy https://t.co/GCYCIuiunS

#ACR21 Abst#0276: Pulse pressure (PP) = Systolic BP - Diastolic BP, measures arterial compliance ⭐️RA: higher PP than controls ⭐️PP was independent risk factor for subclinical atherosclerosis ▶️ Look at the vitals, we have this at every pt visit! @Rheumnow https://t.co/KZaf1AwO6Q https://t.co/kN4xGxWiV9

• https://bit.ly/3GUl4l7

It's what's below the surface that's most scary. see: RA & the heart - why do RA pts without cardiovasc dx/Sx get LV remodelling over time - why is it worse with worse RA control? RA goes deeper than the joints & our pts need to hear that! @Columbia #ACR21 ABST0272 @RheumNow https://t.co/NDHLZwoEjy

Dr Springer on pharmacological response of RTX in ANCA-vasculitis. Suggest that 500mg every 6 months may not achieve sufficient B cell depletion in all. What are the clinical implications? Is anyone dosing 500mg as standard? Abstr#0416 #ACR21 @RheumNow https://t.co/w36hSYbW1B

Some great #SpA posters on #WorkParticipation #ACR21 Abs#0358 •~700 pts •379 (64.2%) took sick leave in last 12m •#Absenteeism in 23.7% & #presenteeism in 84.1% •Huge impact on work participation in SpA despite incr no. of therapeutic agents @RheumNow https://t.co/pwz4s8D1FU https://t.co/wpbjeXNpgm

• Work Participation in Patients with Axial Spondyloarthritis in Germany: Results…

Despite >20y of bDMARDs, our patients still have a 50% greater risk of cardiovascular issues (similar to family history or abdominal obesity) Cardiovascular disease in RA is not historic, it's today's reality we too often ignore. 2020 data @VUamsterdam #ACR21 ABST0286 @RheumNow https://t.co/Az4wHNUOGe

Meta-analysis from @rheum_covid with @HsiehEvelyn shows that people with rheumatic disease are at⬆️risk of SARS-CoV-2 infection and⬆️mortality from COVID-19. Abstr#0086 #ACR21 @RheumNow #ACRBest https://t.co/B7tWs02gfc

#ACR21 Abst#0284. RA and Dementia? ⭐️1366 pts with RA, retro pop-based cohort ⭐️Risks: older age, diabetes, CVD. ⭐️Large joint swelling swelling HR 2.2 (1.2-3.9). No significance by RF/CCP/ESR/erosions/nodules ▶️CVD risks appear > RA activity https://t.co/2uN2lBs4tr @Rheumnow https://t.co/HEOXPosE5Z

• https://bit.ly/3wonCDu

Diabetes puts you at risk of cardiovascular disease, right? What about RA? Look at this graph and compare the pair. "already it was impossible to say which was which” - George Orwell, Animal Farm #ACR21 ABST0287 @RheumNow https://t.co/r0yaeC530l https://t.co/mKJhoyJ2Cn

• 20 Years Follow-up of Cardiovascular Event Risk in Rheumatoid Arthritis Compare…

Study by @BethIWallace @Tuhina_Neogi shows that we seem to treat fibromyalgia symptoms with steroids in RA patients. Its a bad idea in fibromyalgia, and has got to be bad practice in RA too. Abstr#0120 #ACR21 @RheumNow