David Liew drdavidliew
5 years 4 months ago
Great to have my @OMERACT irAE group co-chair and friend @MarieKostine remind #EULAR2021 of the EULAR points to consider for irAEs - still relevant in a fast-moving field!
available here in full @ARD_BMJ: https://t.co/wFZqKsdDoz
in the Oncorheumatology session @RheumNow https://t.co/RuhIlkFRgM
David Liew drdavidliew
5 years 4 months ago
I remember when we used to teach residents how to differentiate RA & PsA patients on imaging from normal scans.
Give the right computer a whole lot of HR-pQCT scans, and it probably can do as well as the teaching rheumatologist...
@LkasDer @maier_ak OP0145 #EULAR2021 @RheumNow https://t.co/kFx3oKzWKc
David Liew drdavidliew
5 years 4 months ago
All credit to the @karolinskainst @Rigshospitalet @WH_Rheumatology investigators for:
- tackling this issue
- bringing it to #EULAR2021
- acknowledging limitations publicly & graciously
😊
It's... complicated. But each time we get closer!
OP0210 https://t.co/2L3RDH276v @RheumNow https://t.co/UtcTukt3r8
David Liew drdavidliew
5 years 4 months ago
We know dementia (which is a/w inflammation) used to be a problem for RA pts.
What's happened with that as we've got better at treating RA?
Not only has dementia in RA pts decreased over time, the gap with non-RA pts has completely closed!
@KronzerMD OP0216 #EULAR2021 @RheumNow https://t.co/bbbnQtv4vE
David Liew drdavidliew
5 years 4 months ago
The advantage of the #EULAR2021 portal - the motivated speaker can answer all the excellent questions that the chairs don't ask! @RheumNow https://t.co/hewk02lFfM
David Liew drdavidliew
5 years 4 months ago
We keep on advancing in rheumatology but some things stay the same:
Our RA pts are stuck with multimorbidity more than other pts, esp for the women
(➡️depression, hypothyroid, T2DM, lung dx)
How can we support all of our pts needs better?
@MayoClinic OP0213 #EULAR2021 @RheumNow https://t.co/0Y96Xa0fi2
David Liew drdavidliew
5 years 4 months ago
I don’t care if we’re virtual, and not actually in Paris.
It’s #EULAR2021 and no-one’s going to stop me from getting my French cheese
@RheumNow https://t.co/w3Juvz5hfc
David Liew drdavidliew
5 years 4 months ago
with TNFi therapy in RA:
new ANA seroconversion is common (75%)
TNFi-induced lupus is rare and mild
(in this cohort of ANA/dsDNA neg RA pts from Porto)
so don't be tempted to serially check the ANA with TNFi Rx! Let's put this rare habit to bed
POS0204 #EULAR2021 @RheumNow https://t.co/5da34Ya3Xp
David Liew drdavidliew
5 years 4 months ago
Which confers greater CV risk:
- RA dx in early 2000s
- T2DM dx c. 1990?
The answer may surprise you.
Amsterdam POS0213 #EULAR2021 @RheumNow https://t.co/SGsgKHf61U
David Liew drdavidliew
5 years 4 months ago
Immunogenicity makes a difference for mAbs like TNF inhibitors.
from Bart van den Bemt #EULAR2021 @RheumNow https://t.co/38ImlXdwUp
David Liew drdavidliew
5 years 4 months ago
So where might mAb therapeutic drug monitoring have the most value for us, going forward?
Proactive testing not at the moment (e.g. NOR-DRUM-A) but plenty of opportunities still exist!
6/
@MeghnaJani #EULAR2021 @RheumNow https://t.co/W5JATFHLfx
David Liew drdavidliew
5 years 4 months ago
So what might therapeutic drug monitoring (TDM) be able to do for you?
1/
@MeghnaJani #EULAR2021 @RheumNow https://t.co/f6x4JAE5pQ
David Liew drdavidliew
5 years 4 months ago
oh wait!
no photos, but NOR-DRUM B results:
Proactive TDM for dose optimisation during infliximab maintenance
- proportion pts w/o dx worsening: TDM better by 15%
- flare risk 2x with standard care vs TDM
- benefit across diseases (incl RA) & subgroups
Wow.
#EULAR2021 @RheumNow https://t.co/nTAuKE2ZJa
Paul Studenic Stiddyo
5 years 4 months ago
Prof. Alten outlined the value of patient-reported outcomes for clinical practice!
How do you collect patient-reported outcomes - PRO - in your rheumatology clinic?
#EULAR2021 @RheumNow
Paul Studenic Stiddyo
5 years 4 months ago
#OP0145 Using a mixture of > 300 individuals with RA PsA or healthy the analyses via neural networks of HR-pQCT can differentiate the diagnosis assessing the bone surface with an accuracy of
89% #EULAR2021 @RheumNow

