Plenary 1: SELECT-GCA (RCT, UPA vs PLBO in GCA) Pts in remission re-randomized at wk52 Higher maintenance of remission in pts who continued UPA15 (69%) vs switchers from UPA15->PLBO (29%) Argues strongly for continuing tx in GCA for >1yr! @RheumNow #ACR25 Ab#0776 #ACRBest https://t.co/exmmIcpgbP

• https://x.com/EBRheum/status/1982473544505372756/photo/1
• https://x.com/EBRheum/status/1982473544505372756/photo/1

tRNA-derived RNA (tDR-1), circulating microbial RNA Associated w/ reduction in risk of RA conversion in asymptomatic CCP+ individuals (60 vs. 120+ ctrls), ‼️ tDR-1 alone over performs prediction model w/ smoking shared episode and RF w/ AUC 0.86 What is the mechanism? tDR-1 https://t.co/fuyk4NeOyA

• https://x.com/AurelieRheumo/status/1982473500922187877/photo/1
• https://x.com/AurelieRheumo/status/1982473500922187877/photo/1
• https://x.com/AurelieRheumo/status/1982473500922187877/photo/1

Ribeiro et al. Case series of combination bDMARD/tsDMARD in PsA from Toronto. 24 patients, median just over a year follow-up. Appear effective, especially for objective skin and joint measures. No major safety concerns but short follow-up to date. @RheumNow #ACR25 Abstr#565 https://t.co/Zk3odT2EX2

• https://x.com/RichardPAConway/status/1982473041276981274/photo/1

#0775 Higher circulating microbial small RNA tDR-1 linked to lower risk of developing RA in CCP3+ individuals (AUC 0.86). tDR-1 downregulates interferon-response genes in vitro, suggesting microbiome-mediated anti-inflammatory mechanism in RA pathogenesis. @RheumNow #ACR25

SLE & arthritis: Is there a difference? Abstract #0629: - Non-deforming (ND): 73% | Jaccoud’s: 19% | Rhupus: 8% - Vs ND, Rhupus had lower odds of type I IFN signature - Time to deformities: Jaccoud's ~2 yrs vs Rhupus ~5 yrs - RNP+ predictive of Jaccoud’s @RheumNow #ACR25

Why do some clinics excel at RA disease activity tracking while others struggle? In the VA, success came down to structure: RA-specific clinics, templates, and staff. Barriers? Time, missing labs, and workflow gaps. @RheumNow #ACR25 Abstract#0222

Managing lupus is complex. How do we ensure quality care? Abstract #0218 convened 8 focus groups: ✅ Support for patient navigators ⚠️ Barriers: low resources, staff turnover 💻 Solution: EHR outreach workflow to flag missed visits & labs @RheumNow #ACR25 https://t.co/BWaIMMEPit

• https://x.com/AkhilSoodMD/status/1982472035658826210/photo/1

Abstract #0607: The age at diagnosis of SLE is rising in US based cohort📈 Those diagnosed ≥30 yrs were: ⬆️ More likely to have oral ulcers, hematologic features, +ANA ⬇️ Less likely to have malar rash or proteinuria @RheumNow #ACR25 https://t.co/pMPVLg1xTZ

• https://x.com/AkhilSoodMD/status/1982472034639814707/photo/1

Damen et al. 10-year follow-up of CRESPA study. Treatment withdrawl trial in early peripheral SpA. 38% in drug free remission. 82% in remission. @RheumNow #ACR25 Abstr#568 https://t.co/KOVW5pSbJg

• https://x.com/RichardPAConway/status/1982471531679670379/photo/1

Abstract 0196: Too many referrals, too few slots? A hybrid RN + MD referral cut wait times for patients with SLE by 26% Median time to appointment 69 days --> 51 days Next steps: streamline high-risk triage, reduce manual chart review @RheumNow #ACR25

DESIR cohort of early axSpA: ✳️Factors assoc w/ D2M axSpA - female sex, ⬆️ASDAS-CRP ⬆️BASFI ⬆️ASQOL at baseline. ✳️ Low prevalence of pts meeting D2M definition (15 pts - 8.4% bDMARD-treated) #ACR25 @RheumNow Abs0544 https://t.co/fBUh3myKcz

• https://x.com/RHEUMarampa/status/1982471028388372791/photo/1

Abstract #0189: Rheumatologists are early adopters and high utilizers of #AI scribes. 📊 Adoption: 41% 🧑‍💻 Retention: 100% 💬 High utilizers (> 70% visits): 83%. The highest among IM subspecialties 🕒 AI scribes reduced EHR time across all measures. @RheumNow #ACR25 https://t.co/TBurWUKhMl

• https://x.com/AkhilSoodMD/status/1982470273963036864/photo/1

Ramiro et al. No significant differences seen between men and women in response to upadacitinib in AxSpA at week 14 or 52. Differs from data on TNFi/IL17i in this regard. Looks to me like men respond a bit quicker and better though... @RheumNow #ACR25 Abstr#589 https://t.co/2m7mrgcG0z

• https://x.com/RichardPAConway/status/1982470273321603412/photo/1

This retrospective cohort analysis by Dr. Lihi Eder et al showed that among patients with PsA, those w/ high dse activity & high 3VAS scores were assoc w/⬆️ risk of atrial tachyarrythmias. Main message: PsA conveys ⬆️CV risk; inflamm control is key! #ACR25 @RheumNow Abs0522 https://t.co/7sRM7K4V1c

• https://x.com/RHEUMarampa/status/1982469770881683713/photo/1

In a nationally representative NHANES sample, inflammatory back pain (IBP) was not associated with HLA-B27 positivity or elevated CRP, regardless of IBP criteria used (e.g., Berlin 8a: OR 0.88, p=0.876). IBP alone may be insufficient for identifying axSpA-related immunogenetic or https://t.co/82NjVU171z

• https://x.com/synovialjoints/status/1982469770021867853/photo/1