Infection data from SELECT-GCA: Glucocorticoids seem to drive overall infectious risk UPA use associated with higher zoster - vaccinate!! @RheumNow #ACR25 Abst# 0895 https://t.co/ueVbFPxG0Q

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Who with #SSc-ILD will progress? progression is non linear - can stabilize and worsen Search for Predictive biomarker For clinical care & enriching RCTs Maybe #KL6 🤷‍♀️ Maybe IP-10, MIG No strong #biomarker Depends on what is used #ACR25 @RheumNow @ACRheum Abst#0882 #0883 https://t.co/lyTRUEY9SI

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After At-risk RA, time to discuss At-risk PsA patients ARP-PsA Prospective cohort 1400+ pts 8.4% met ARP-PsA criteria (arthralgia + Fam Hx +Pso, not referred via Dermatology) Risk factors: Pso >15 years Pso + Family Hx US synovitis/enthesitis At 1 yr follow-up 30% progressed https://t.co/ZY2ezh8nZN

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Prednisone remains both lifeline and liability. New PRED-SAFE SDM tool helps patients and clinicians navigate that tension—visualizing benefits and harms to guide tapering. In pilot testing, 93% had no residual decisional conflict. @RheumNow #ACR25 Abstract#1052 #ACRbest https://t.co/CgQ75N7A1p

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Abstract 1431: Radiographic sacroiliitis in #PsA: insights from an Indian cohort - Cervical and lumbosacral spine syndesmophytes were common - Levels C5, C6, and L4 vertebrae frequently involved including syndesmophyte damage w/ non-marginal bridging @RheumNow #ACR25

Picture this 👉radiographic joint damage tied to worse physical function in #PsA: 🔹 ↑ mSS → ↑ HAQ (β=0.003 [0.002–0.004]) 🔹 ↑ mSS → ↓ SF-36 PF (β=−0.10 [−0.15 to −0.05]) 🔹 ↑ # of damaged joints → worse physical function @RheumNow #ACR25 Abstract 1425

Abstrat 1414 Compared to #PsO, early #PsA showed: 🔹 ↑ Dactylitis (66%), Enthesitis (78%), CRP/ESR 🔹 Longer morning stiffness & ↑TJC/SJC 🔹 MRI/US: frequent tenosynovitis & bone changes 🔹 Predictive model combining these features showed Sens 89%, Spec 84% @RheumNow #ACR25

Abstract 0878: In PsA pts w/ lateral epicondyle enthesitis on secukinumab (n=11): 🔹 Improved DAPSA & SPARCC scores 🔹 entheseal tissue biopsy showing shift toward pro-resolving fibroblasts (↑DKK3/CD200⁺) 🔹 ↓ osteoblast-related pathways @RheumNow #ACR25

Kuzkina et al. Efficacy of IL-6i with olokizumab on depression in RA. There appear to be some benefit but anti-depressants still needed. Group 1 is olokizumab alone, other 2 groups have anti-depressants also. @RheumNow #ACR25 Abstr#1323 https://t.co/h2ExYQgKTL

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Mayer et al. NSAIDs in IBD. Retrospective cohort study. 250000 individuals. Non-inferiority study. No increased IBD-related hospitalisation in UC, but an increase in all-cause hospitalisation. @RheumNow #ACR25 Abstr#1434 https://t.co/he2Xmcqslk

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Post Hoc analysis from SELECT-GCA Increased rate of herpes zoster for 26wk steroid-UPA 15mg (7.3% vs 4.2% 52wk steroid-plbo) but lower rate of SERIOUS infections (7.9% vs 12.7% 52wk steroid-plbo) Zoster risk is real; steroids are the bigger problem @Rheumnow #ACR25 Abstr#0895 https://t.co/IKzO2J4hLH

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@RheumNow on virtual learning: It’s integrated in clinical care, research and #MedEd How to manage info overload? - schedule, make use of tools - use AI to curate, analyze & focus #ACR25 @rheumarhyme https://t.co/ogCezlnxUP

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X-sectional study by Dr Toledano et al showed that 20% (46/230) PsA pts had restless leg syndrome (RDS). Pts w/ RDS: - Polyarthritis ⬆️ Swollen jts ⬆️ Fatigue, anxiety, depression ⬆️ Dse activity Poor sleep quality Polyarthritis & Pso: assocd w/ RDS #ACR25 @RheumNow Abs1413 https://t.co/8Ds3TgLjs1

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In ICONIC-LEAD, adolescents (12 to <18 years) with moderate-to-severe psoriasis treated with icotrokinra (ICO) achieved Investigator Global Assessment (IGA) 0/1 in 84.1% vs 27.3% (placebo) and PASI 90 in 70.5% vs 13.6% at Week 16. Week 24 responses reached 88.6%. Safety profile https://t.co/L7h8BlnWaO

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Concerns using dupilumab in EGPA due to secondary eosinophilia What about when combined with IL-5 therapy? 16 pt on dupi + IL5 agent - if dupi alone caused eosinophilia -> quelled by IL-5 - no eosinophilia when dupi added to IL-5 - effective but slow @RheumNow #ACR25 Abst 1605