TriNetX database 4000+ pts PsA + GLP-1 RA & 86000+ PsA non GLP-1 ctrls Without much surprise GLP-1 treated pts had lower risk of MACE and death Observational, retrospective study. Now awaiting the prospective evidence. RCT on the way but capturing MACE and death are always https://t.co/GWbAMC1mJK

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Next Generation T-Cell Engager: The Future https://t.co/gcrfzV6MSJ via @YouTube @alhkim great to see you and hearing all about new T cell Engager , feasibility and less toxicity. @RheumNow #ACR25

• Next Generation T-Cell Engager: The Future

#0851 Urinary Tenascin C predicts kidney function loss in lupus nephritis 170 AMP-LN patients: Tenascin C (from renal myofibroblasts) was the top predictor of eGFR decline (HR 4.6) Proteomic 11-marker risk score (AUC 0.91) outperformed proteinuria for prognosis #ACR25 @RheumNow

In the #ACR25 Great AI debate, @RADoctor shows automated ultrasound scanning - one legitimately promising application ready very soon. I’ve written about this work (ARTHUR/DIANA) for @RheumNow last year - check it out: https://t.co/Zq4ywEjspi https://t.co/3RYCVunE3a

• Will the Robots Save Ultrasound? | RheumNow
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#0852 LEVI-04, a novel p75NTR-Fc fusion protein, significantly reduces MRI bone marrow lesions in knee #OA 🦵📉 Phase II RCT (n=518): dose-dependent BML reduction (p<0.001) + correlated improvement in pain & function. Promising structure-modifying OA therapy @RheumNow #ACR25 https://t.co/huA8OaFGSd

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@JYazdanyMD in the #ACR25 Great AI Debate details out three key risks of AI in rheumatology: - bias at scale - erosion of skills - data regulatory issues (for what it’s worth, amongst all the potential upside, I think it’s very real. It’s up to us to make it better) @RheumNow https://t.co/FyNes40Z7q

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In this ph2 trial of LEVI-04 for knee #osteoarthritis, At wk 20, LEVI-04 ⬇️ bone marrow lesions (BML), greater ⬇️ in BML area even w/ higher KL grades Promising treatment. #ACR25 @RheumNow Abs0852 #ACRBest https://t.co/MrmLPlFiDs

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Summary take home points by Dr Highland 1. PAH and PH-ILD are associated with high mortality in patients with SARDs 2. Multimodal and early screening is recommended 3. “It takes a village” work with Pulm and Cardiology colleagues @RheumNow #ACR2025 https://t.co/Xa7TecMOIe

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In the #ACR25 Great AI Debate, @RADoctor and @JYazdanyMD prepared independently, but in consecutive moments agree (in a very illustrative way): guardrails - they need to happen @RheumNow https://t.co/ccLLC3adxG

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The CLASSIC study (n=1015, 27 countries) validated revised ASAS-SPARTAN axSpA criteria. Final model achieved 79.5% sensitivity & 90.4% specificity vs global diagnosis. MRI SIJ (active + structural) was strongest predictor. HLA-B27, CRP, IBD, uveitis also included. Abstract#0854 https://t.co/GjSHE2ihVI

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#0853 Olink proteomics in anti-Ro+ pregnancies identifies macrophage-derived IL-6 & CCL3 as serum predictors of foetal AV block These pro-inflammatory proteins predicted fAVB independent of maternal diagnosis or Ab titres, pointing to new pathogenic pathways. @RheumNow #ACR25

#1627 SLR informing the 2025 @eular_org recommendations for PMR & LVV 🔍 141 studies (30 RCTs) reviewed: new & further evidence for IL-6, JAK & B-cell-targeted therapies. Data will underpin updated management guidance. @RheumNow #ACR25

#0854 @Official_ASAS & @SPARTAN_Updates revised #axSpA criteria meet targets: Sn 79.5% / Sp 90.4%. Imaging is central (SIJ MRI + structural lesions) with focused clinical items: HLA-B27, IBP, uveitis, IBD, heel enthesitis, psoriasis, ↑CRP @RheumNow #ACR25 https://t.co/i2d12y9HcD

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Summary of (some) drugs in the pipeline for management of PAH. Slide credits: Dr Benjamin Freed ⁦@RheumNow⁩ #ACR2025 https://t.co/qazQNk4ovR

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#1614 Another SLR informing the 2025 EULAR recommendations for PMR & LVV 🧭 Fast-track clinics cut blindness & diagnostic delays; multimodal imaging pathways outperform biopsy alone. Key data shaping future referral & diagnosis guidance. @RheumNow #ACR25