Who does worse with #SLE #nature vs #nurture South American #lupus #registries ⬆️ activity ⬆️damage ⬇️age ⬇️SES ⬆️SLE #antibodies #Gladel registry and others vs Europe Environment >genetics 🤔 #LUPUS2025 #45poster @RheumNow @gponsestel https://t.co/XjiXHAMuGm

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do’s & don’t #Lupus #nephritis ❎ Don’t sequential monotherapy ▶️ use #MMF + #biologic or #CNI ✅ Do a #biopsy ➡️ need to know #dx #px Do target LOW proteinuria Do treat comorbidities Lipids HTN Fluids BMI ?mood No #NSAIDs Do limit #pred #SGLT2i @RheumNow #LUPUS2025 https://t.co/D0vHQXYTvZ

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Impt predictors of #neuropsychiatric #SLE #LUPUS2025 @RheumNow No major predictors But if explanation of other conditions ex Past #cvA #ischemic events Doesn’t have to have ➡️Active systemic ##Lupus ➡️ ?ribosomalP +Abs described in #CNS lupus A real headache! https://t.co/iuWfB454EN

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‘It’s #Lupus, it’s all in your head!’ ➡️ Some patients with #SLE have heard this from others At #LUPUS2025 in a packed session on #CNS lupus #Dx is tricky 40% of #neuropsychiatric lupus have NEGATIVE #brain #MRI 👇r/o infarct/bleed Infection Rx #steroids @RheumNow https://t.co/yU1olg0uZU

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Steroids prevention of #congenital #heart #block in +Ro Mom #DM #HTN #wt⬆️ Fetus ?no diff #cardiomyopathy ?learning &behavioural changes Debate re screen #CHB Most CHB are kids w CHB as mom is unknown to be +Ro Angst w screening High titre Ro Impt @RheumNow #LUPUS2025

Do you routinely recommend SLE +Ro/La pregnant Pts to have routine screening for #congenital #heart #block #LUPUS2025 @RheumNow

‘To screen or not’? For #CHB #congenital #heart #block Great debate #LUPUS2025 In #pregnant women with #SLE In + #Ro #SSA &/or #La #SSB mothers CHB Rx - #flourinated #steroids To ⬇️#fetal #mortality ❎no benefit ⬇️#cardiomyopathy ❎ ⬇️#pacemaker ❎ ⁦@RheumNow⁩ ??🤷‍♀️ https://t.co/xauDzfNBsC

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Level up 🆙 #hydroxychloroquine #levels in #SLE When to determine adherence - too low To see if levels are supratherapeutic Who SLE Pts who have risks for #HCQ toxicity#CKD, liver dx, age, overdosing Why Safety Adherence ⁦@RheumNow⁩ #LUPUS2025 https://t.co/l8FPcqmTki

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#Proteinuria that persists in #LN #lupus #nephritis even w mild proteinuria 👇 Worse outcomes Just like all CKD Take home Aim for None or minimal in #SLE <150 protein #voclosporin >> PBO (SoC) 1/2 Voclosporin had deep response at least once > PBO #LUPUS2025 @RheumNow https://t.co/CBUzyBatBh

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Any ‘toll’ in #toll #like #receptors 7,8 in #SLE Cutaneous #lupus In #systemic or #cutaneous wk16 Rx PBO V #enpatoran No obvious dose response - all 3 dose >PBO Safe so far improves IFN No toll to pay! 👍 But need Ph3 data #LUPUS2025 @EricFMorand @RheumNow https://t.co/2DDztlVsUm

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Systematic review and meta-analysis confirms modest efficacy of infliximab for pulmonary sarcoidosis and promising but limited evidence for adalimumab, tofacitinib and efzofitimob in specific sarcoid manifestations. https://t.co/XaqSiAVQTa https://t.co/DTGbIiPT3a

• Systematic review and meta-analysis of the efficacy of biologic and targeted sy…

Systemic sclerosis is a vasular disorder! Microvascular dysfunction, Endotheliopathy, & reduced vascular reserve account for most findings. Good review w/ literature references in Arthritis Research & Therapy. https://t.co/ULfwBy7ECb https://t.co/QnpImUrA7q

• Endotheliopathy in systemic sclerosis: from endothelium-dependent vasodilation …

Is Lupus Just a B Cell Disorder? https://t.co/0kwxE6KLeI https://t.co/pORHkg9HY6

• Is Lupus Just a B Cell Disorder? | RheumNow

Moving Targets in Lupus and Lupus Trials In the 1990s, lupus treatment development became a major focus, but progress was slow. Belimumab was eventually approved by recognizing that trials could only show small differences from placebo, requiring 867 patients globally to https://t.co/xrj8r1iNxr