@abdelhamed012 @RheumNow Same https://t.co/uScez6UwBp

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Race of b/tsDMARDs in RA, the “JAK-pot” study. JAKi and TNFi with more rapid early improvement in CDIA, HAQ, and pain compared to ABA or IL-6 inhibitors…..although effects blunted after adjusting for patient and RA characteristics #ACR24 @RheumNow ABST#0501 https://t.co/8M4wX3LAbW

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🤵‍♂️Results from BACHELOR ➡️34 PMR pts ➡️18 BARI, 16 PBO ➡️Primary endpoint: CRP PMR-AS≤10 w/o oral GC rescue from W0 to 12 78% BARI pts reached primary endpoint vs 13% PBO No new safety signals BARI 4mg 12W, then 2mg 12W➡️36W low disease activity in PMR Ab0858 #ACR24 @RheumNow

How does #cardiovascular risk vary with #ACPA & #biologics in #RA? ⬆️BMI assoc with ⬆️MACE risk in ACPA+ pts In ACPA- pts, BMI inversely assoc with MACE risk among pts on biologics Further evidence to consider ACPA, BMI & MACE as part of RA management Ab0870 #ACR24 @RheumNow https://t.co/UkkC146DWS

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JAKs in PMR? "BACHELOR" study randomized 34pts to BARI vs PLBO Despite small sample, significant benefit at 12 wks (CRP PMR-AS < 10) for bari (78%) vs. PLBO (13%) Useful, but not for getting regulatory approval. Should have gone straight to phase 3! #ACR24 @RheumNow Abstr#0858 https://t.co/mmMs6c3AYC

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📸 #ACR24 Selfie Highlights! 1️⃣ @Sethsaidso and Jack Cush, MD from @RheumNow – a dynamic duo in rheumatology! 2️⃣ @Sethsaidso and @KenSaag, MD, MSc – renowned rheumatologist and clinical investigator from UAB. 3️⃣ @Sethsaidso and @Dr_ValenzuelaMD – exceptional rheumatologist from… https://t.co/9AseHvXE1V https://t.co/Vr5rxkmCqH

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How early is early? Data from SPACE cohort included 548 pts with CBP (<2y duration) and different SpA features followed over 2years. -At the end of 2 years, 39% pts were dx with axSpA. -Median time to dx: 35 months. -HLAB27+, sacroilitis on MR and peripheral arthritis were the… https://t.co/AYtJCp8yno https://t.co/VL7KSrpvp9

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Systematic review suggests (although not provn) that audiovestibular dysfunction may be from APS. Anti-phospholipid & HSP-70 Abs found 25-33% w/idiopathic sudden sensorineural hearing loss,. ACL Abs seen in up to 27% w/ sensorineural hearing loss https://t.co/WcmeCP0ryq https://t.co/DiYX57R0uG

• Audiovestibular Dysfunction Related to Anti-Phospholipid Syndrome: A Systematic…

Is it pre-eclampsia or lupus nephritis flare? Abstract 0809: The sFlt-1/PlGF ratio may help distinguish preeclampsia from lupus nephritis in pregnancy. A low ratio ruled out preeclampsia, while a high ratio ± proteinuria suggests increased risk. @RheumNow #ACR24

Cross-sectional study finds metabolic dysregulation in RA-ILD is indicative of poor prognosis- FGF-21 assoc w. poor survival. Another link btwn CV risk factors, metabolic syndrome & RA? Should we be doing more to manage metabolic risk factors in RA-ILD? Ab0803 #ACR24 @RheumNow

Stone et al. Phase 3 RCT B-cell depletion with CD19 targeting agent Inebilizumab in IgG4-RD. HR 0.13 (0.06, 0.28) for flare. @RheumNow #ACR24 Abstr#0775 https://t.co/Kd4Xmoc5e6 https://t.co/Al6gOA1F8K

• A Phase 3, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study of I…
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Hamroun et al. Meta-analysis of glucocorticoids in pregnancy and breast-feeding. Increase pre-term birth with GCs, adjusted OR 2.24. Dose-dependent effect. Minimal breastmilk transfer. @RheumNow #ACR24 Abstr#0810 https://t.co/H0o9ElsHmc https://t.co/uciFP6UOhF

• Glucocorticoids in Pregnancy and Lactation: Results of the Systematic Review In…
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Prof @WalterMaks et al reports the validation of data-driven quantitative MRI cutoffs for a +SIJ MRI perform highly in pts with established axSpA. - Deep fat lesions & sclerosis: high specificity for #axSpA @RheumNow #ACR24 abs821 https://t.co/sSAtTt1GGV

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Not just the presence but higher levels of biomarkers predict RA-ILD progression. #ACR24 @RheumNow ABST#0804 https://t.co/5jhBjXDUeY

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