FDA Safety Warning: denosumab now has a Boxed Warning for risk of severe hypocalcemia in CKD pts taking Prolia (usually seen 2-10 wks post injx). Pts may or may not be symptomatic. CKD pts should have Ca and Creatinine monitored. https://t.co/UMYxjWz9n4 https://t.co/AG5wzBrY1Y

• Osteoporosis drug Prolia increases the risk of severe hypocalcemia

Rheumatologists and the Early Diagnosis of Spondyloarthritis SPACE study of adults referred to rheumatology with less than 2 years of chronic back pain (CBP), shows that only one-third can be reliably diagnosed with axial spondyloarthritis (axSpA). https://t.co/nUappTl0wG. https://t.co/oouir55CO6

• Rheumatologists and the Early Diagnosis of Spondyloarthritis | RheumNow

Prevalence of Cardiovascular Disease in Rheumatoid Arthritis A prospective study of the BioSTAR registry estimates the prevalence of cardiovascular disease in rheumatoid arthritis (RA) to be 4.6%. https://t.co/NRn0DrYoBX https://t.co/qOoTmBNB1p

• Prevalence of Cardiovascular Disease in Rheumatoid Arthritis | RheumNow

#RNL2024 @RheumNow SPA spectrum Q and A 🔥 - @lihi_eder 👏advocating for #POCUS #mskus and enthesitis - we agree @CrusSurc - confirming the concept of #pocus as an extension of the clinical exam and to be kept in the hands of the clinician - doesn't seem an area yet for AI 🤖

Oh, snap! But this is true, a single course rituximab at baseline and none at 6 months (or anything else) as a comparator is just wild in a 12 month trial @EBRheum @RheumNow #RNL2024 https://t.co/wuIkuLzIpg

• https://twitter.com/RichardPAConway/status/1751669467816358253/photo/1

A picture paints a thousand words. One of the reasons why statistical significance is not the be all and end all. I would say severe DAH is the most likely scenario I would use PLEX, more so than severe renal disease. @EBRheum @RheumNow #RNL2024 https://t.co/GHg6t4OHxf

• https://twitter.com/RichardPAConway/status/1751668461229805651/photo/1

Rituximab is superior to cyclophosphamide in relapsing AAV. Provided you are relapsing after having cyclophosphamide as your first agent of course... @EBRheum @RheumNow #RNL2024 https://t.co/JfbcKH2zCG

• https://twitter.com/RichardPAConway/status/1751667454776934533/photo/1

Does adding NSAID to TNFi help prevent radiographic progression? @LianneGensler #RNL2024 @RheumNow Adding Celecoxib to TNFi: numerically less progression, but not statistically significant https://t.co/rzuOL9q93x

• https://twitter.com/ericdeinmd/status/1751659957642985688/photo/1

Dr. @lihi_eder approaches enthesitis both clinically and with imaging *highly recommended. NSAIDs and local steroids may be useful with caution. Advanced tx strongly recommended if initial tx fails/other domains involved. #RNL2024 @RheumNow https://t.co/SKrWmp115M

• https://twitter.com/uptoTate/status/1751658300230287819/photo/1

Vedolizumab-induced enthesitis @lihi_eder #RNL2024 @RheumNow 11/90 (12.2%) of pts on VDZ for IBD w/ develop new-onset enthesitis Is this true drug rxn or previously masked by prior meds (TNF)? Usually unilateral +/- oligo, dactylitis Most respond to NSAID or injxn, 27% change Rx

Enthesitis @lihi_eder @RheumNow #RNL2024 - NSAID - 1st line in mild/isolated - GC injxn but caution at Achilles - MTX cond rec by GRAPPA (SEAM PsA) - All bDMARD work vs PBO (TNFi, IL17, 12/23, 23, JAK, PDE4) - none superior - IL17 v ADA: higher resol for IXE v ADA, but mixed data https://t.co/20KnQo4kpq

• https://twitter.com/ericdeinmd/status/1751657096867717530/photo/1
• https://twitter.com/ericdeinmd/status/1751657096867717530/photo/1

Advanced therapies in enthesitis. Don't believe the spin, they all work, no clear evidence that any agent is better than others. @lihi_eder @RheumNow #RNL2024 https://t.co/FwLMUmmClB

• https://twitter.com/RichardPAConway/status/1751656884971384895/photo/1

@JointMD updates us on nomenclature. "AS" is out and "AxSpA" is in. #RNL2024 @RheumNow https://t.co/gdmZeuMNpW

• https://twitter.com/uptoTate/status/1751653815617560883/photo/1

#RNL2024 @RheumNow @lihi_eder on enthesitis - ~1/3 PsA, SpA - Enthesitis precedes onset of PsA in PsO, high u/s score ass. w/ RFs (BMI, nail dyst) - Exam: tenderness (non-specific), as swelling uncommon. U/s helpful, but non-specif - Marker of severity, higher risk of damage

Dr. @lihi_eder recommends enthesial evaluation with POC ultrasound if available in addition to her clinical evaluation. #RNL2024 @RheumNow https://t.co/LQiyFK5VB1

• https://twitter.com/uptoTate/status/1751653188321612054/photo/1
• https://twitter.com/uptoTate/status/1751653188321612054/photo/1