Dr. John Cush RheumNow
2 years 8 months ago
Best of 2023: 2023 ACR/EULAR Criteria for Calcium Pyrophosphate Deposition Disease
The prevalence of radiographic chondrocalcinosis is estimated to be 4% to ≥10% in older adults, but the prevalence of symptomatic CPPD disease is unknown.
https://t.co/gsCtfHzn4Z https://t.co/lIaf36epZY
A EULAR/American College of Rheumatology task force has established evidence based, up-to-date guidance and expert opinion on the evaluation, management and monitoring of patients with Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS), with the primary intent to halt disease progression and prevent life-threatening complications from HLH/MAS.
Please don’t tell your patient that PMR “typically” lasts two years. According to real-world data from the UK, one in four patients with PMR is prescribed steroids by their primary care physician for over four years. But nobody tells them this at the start, and that causes big problems later on.
Dr. John Cush RheumNow
2 years 8 months ago
Best of 2023: How Being a Patient Taught Me to Be a Better Doctor
Since I can remember, I always wanted to be a doctor. My dad was a trauma surgeon and my mom a nurse.
https://t.co/JE4QoJy4jp https://t.co/jrJoqRD30P
Dr. John Cush RheumNow
2 years 8 months ago
Best of 2023: LAVLI - A New Autoinflammatory Disorder
NIH researchers have have described a novel autoinflammatory disorder called "Lyn kinase-associated vasculopathy and liver fibrosis" (LAVLI), based on a mutation in the LYN gene.
https://t.co/5nzq6KvOpy https://t.co/Y2MCXkGck2
Dr. John Cush RheumNow
2 years 8 months ago
STOP-RA study on HCQ preventing RA... HCQ did NOT prevent RA development in pre-RA pts
#RNL2023 https://t.co/BqZlajMOLK https://t.co/Omui3LWiPi
Dr. John Cush RheumNow
2 years 8 months ago
Avacopan in GPA
- non-inferior to prednisone for induction remission
- received FDA approval for treatment of severe active GPA in combo with standard therapy and steroids
- should be used in newly diagnosed active or relapsing disease
@rheumnow
#RNL2023 https://t.co/yxujTvbVGp https://t.co/UfOkrJDgcU
Dr. John Cush RheumNow
2 years 8 months ago
Full Read comprehensive review by Isenberg et al-what Rx works in SLE; review of RCT data on approved & developing drugs:
- Obinutuzumab
- Dapirolizumab
- Deucravacitinib
- Litifilimab
- Atacicept
- Telitacicept
https://t.co/4JvbZ6ysWn https://t.co/FePnuTsHhN
An international task force of 13 European experts have developed evidence-based points to consider regarding the cost-effective use of biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in the treatment of inflammatory rheumatic diseases (including rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis).
A new study suggests that use of ELISA assays for CXCL-10 and IFN-α can predict which ANA+ individuals may progress to developing a systemic autoimmune rheumatic disease (SARD).
Dr. John Cush RheumNow
2 years 8 months ago
Does King Charles have Sausage Digits (dactylitis) or OA? https://t.co/HpOdaXAxff https://t.co/HpOdaXAxff https://t.co/IrjJcxUG9b
Dr. John Cush RheumNow
2 years 8 months ago
MSK Syndrome from Dupilimab, an IL-4/13 Inhibitor. A new MSK syndrome of inflammatory enthesitis/arthritis/tenosynovitis has been described in atopic dermatitis (AD) patients treated with the IL-4 receptor antagonist, dupilumab. https://t.co/w5djtUzAGG https://t.co/eGMJQJ6Pw2
Dr. John Cush RheumNow
2 years 8 months ago
Prospective study.of 370 #FM pts (79% F; age 34yrs), and 79% were female w/ 14.3 tender points. A delay in Dx was signif correlated with Sx Severity Scale (r = 0.14) & tender points (r = 0.16), but not widespread pain. Early Dx = less severe FM. https://t.co/URvzRa1c3P
Dr. John Cush RheumNow
2 years 8 months ago
Analysis of 14,958 RA pts in Japans National Database of Rheumatic Diseases (NinJa) shows women had higher DAS28-ESR values than males, despite no obvious difference in other indices or disease activity categories. https://t.co/bLFmRdulCw
Dr. John Cush RheumNow
2 years 8 months ago
Metanalysis of Steroids in hosp community-acquired pneumonia (CAP). 18 studies, 4661 pts. Corticosteroids reduced mortality in more severe CAP(RR 0.62; 0.45 to 0.85), but not less severe CAP(RR 1.08). Steroids lower need for mech ventilation, ICU https://t.co/1QbuCZRXze https://t.co/16qiqIatJq

