GRAPPA has provided new, evidence based updates to the management of enthesitis in patients with psoriatic arthritis (PsA), affecting at least 30% of PsA patients and is associated with more severe disease, x-ray damage, and poorer outcomes.
ChatGPT is a new, artificial intelligence chatbot that has dramatically changed the digital worlds of education, research, graphic design, statistics and more. While this AI driven platform has the untold potential in generating written content, there is considerable concern in assuring that human-generated content of research, education and publishing has veracity.
Dr. John Cush RheumNow
3 years 7 months ago
Early ph II Pilot trial of 30 Systemic Sclerosis Pts using a new antifibrotic FT011 400mg vs 200mg v PBO x 12 wks showed CRISS score improved by 60% (400mg; (p=0.02 ) or 20% (200mg) at 12wks. An OL extension is planned for 9 mos @400 mg/d. https://t.co/8R51VLUbvX https://t.co/vc3JJKXfk3
Dr. John Cush RheumNow
3 years 7 months ago
Novel Proteomic Biomarker Set in Osteoarthritis
NIH funded researchers have developed a set of serum proteomic biomarkers that successfully predict clinically relevant KOA progression (both structural change and joint pain) over a 2 year period.
https://t.co/4xU2bYS0xN https://t.co/Rtdr280ghe
Dr. John Cush RheumNow
3 years 7 months ago
Physician Burnout Remains, Less So in Rheumatology
The 2023 Medscape Survey on Physician burnout ranks rheumatology at #10; which is down from #2 when the survey was last done in 2021.
https://t.co/IsC8TQ95RH https://t.co/BBQaSUnQoj
Dr. John Cush RheumNow
3 years 7 months ago
1st there was combined Rheum-Derm or Rheum-Pulm clinics. Medscape reports new Rheum-Cardiology clinics at Cleveland Clinic, NYU, Brigham, Stanford. Useful in research, managing Rheum pts a) at hi CV risk, B) having procedures/surgery, c) risk reduction https://t.co/Y5KDv7wSho https://t.co/WjHVxOQ1xJ
Exercise is known to improve function, pain and quality of life (QOL) in patients with knee osteoarthritis (KOA), but optimal amount of exercise is unknown. The Annals of Internal medicine has reported the results of high-dose versus low-dose exercise therapy demonstrating no benefits from more intense exercise.
Dr. John Cush RheumNow
3 years 7 months ago
Join us at RheumNow Live this March!
Dr. Janet Pope ( @janetbirdnope) will be back to discuss decisive therapeutics in RA.
https://t.co/1aUe1mk4La https://t.co/R1xRMDK6MK
Dr. John Cush RheumNow
3 years 7 months ago
Herpes Zoster with JAK Inhibitors
A recent review a higher HZ risk with JAKi therapy shows the HZ-risk in RA and UC to be higher than PsA when treated with usual doses of TOFA, especially those given higher TOFA doses or concomitant glucocorticoids.
https://t.co/rlYXJWONyS https://t.co/nwqbbp6Ci3
Dr. John Cush RheumNow
3 years 7 months ago
Is JAKi therapy safe in RA-ILD pts? Italian retrospective study (2018-June 2022) w/ 43 RA pts & HRCT proven ILD (med age 69yrs) & Rx w/ JAKi. After 19 mos F/U, the FVC was stable in 79%, improved in 11%, & worse in 11%. DLCO & HRCT trend was similar. https://t.co/T0rP96FM0Z https://t.co/W8NFtfevQg
Dr. John Cush RheumNow
3 years 7 months ago
Rretroperitoneal fibrosis Tx is fraut-steroids, tamoxifen, MMF, B cell therapy? OL trial in 8 RPF pts used steroids & mTOR inhibitor sirolimus (2mg/d x 3d; 1mg/d); 12 & 48wks - decr in fibrous tissue 50%, ESR 70%, IgG4 50% w/ normalized renal funct.
https://t.co/LbptMLCiJO
Dr. John Cush RheumNow
3 years 7 months ago
Can something as simple as a cup of coffee with milk have an anti-inflammatory effect in humans?
Apparently so, according to a new study. A combination of proteins and antioxidants doubles the anti-inflammatory properties.
https://t.co/vuZwsrojwH https://t.co/NFNqHOKuOz
Dr. John Cush RheumNow
3 years 7 months ago
FDA has approved the 1st BTK (Bruton’s tyrosine kinase) inhibitor (Jaypirca™ or pirtobrutinib) for adults with refractory mantle cell lymphoma. BTK inhibitors are also being developed for use in MS, RA, SLE, pemphigus & more https://t.co/599tK21H1Z https://t.co/KSqMMDWmfd
Dr. John Cush RheumNow
3 years 7 months ago
US Postage, circa 1949 "The Doctor" from a painting done by Sir Luke Fildes, “The Doctor” 1891. Portrays the values of the ideal physician and the inadequacies of the medical profession. Child in a 'crisis' (forefront) and ' dawn' light represents hope. https://t.co/OaECk6MlMZ
Dr. John Cush RheumNow
3 years 7 months ago
Jan 2023 Medscape Physician Burnout Report: lists Rheum @ #10 (down from #2)
1 Emergency med 65%
2 Int med 60%
3 Peds 59%
4 OB & ID 58%
5 Family med 57%
6 Neuro, Anesth 55%
7 Pulm, XRay 54%
8 Onc, GI 52%
9 Surgery, Endo 51%
10 Rheum 50% https://t.co/n66oi1Ah73 https://t.co/qTF4t2NTca

