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Early Ph IIa study of ATI-450 (Zunsemetinib), an investigational selective MAP kinase–2 (MK2) blocker leds to a sustai

Dr. John Cush RheumNow

3 years 7 months ago
Early Ph IIa study of ATI-450 (Zunsemetinib), an investigational selective MAP kinase–2 (MK2) blocker leds to a sustained antiinflammatory effect; studied in 19 RA pts w/ ACR 20/50/70 of 60%/33%/20% at wk 12. https://t.co/IyjJCgdXG2
"Dry Synovitis" exist in juvenile arthritis pts? Study of 12 DS pts, says its different from Poly #JIA; onset 6.1 yrs,

Dr. John Cush RheumNow

3 years 7 months ago
"Dry Synovitis" exist in juvenile arthritis pts? Study of 12 DS pts, says its different from Poly #JIA; onset 6.1 yrs, w/ polyarthritis, no palpable swelling, progressive LOM/contractures, neg ESR/CRP/RF/CCP, +MRI synovitis w/ osteochondral involvement.https://t.co/tL2G7QKBL4 https://t.co/k4QoAmTGYA
Rheumatic Disease - IBD Overlap
  • MedPage Today
Nearly one in 10 patients with inflammatory bowel disease (IBD) also have rheumatologic disorders, meaning that specialists have to talk to each other to develop a treatment plan that works for both conditions, a researcher suggested.
AI Passes U.S. Medical Licensing Exam
  • MedPage Today
Two artificial intelligence (AI) programs -- including ChatGPT -- have passed the U.S. Medical Licensing Examination (USMLE), according to two recent papers. The papers highlighted different approaches to using large language models to take the USMLE, which is comprised of three exams: Step 1, Step 2 CK, and Step 3.
Have a Rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell u

Dr. John Cush RheumNow

3 years 7 months ago
Have a Rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/RaFKTqhQjN https://t.co/hH0NcpOoyx
A great study of a recently described rheumatologic/hematologic disorder VEXAS (vacuoles, E1-ubiquitin-activating enzyme, X-linked, autoinflammatory, somatic) syndrome recently appeared in JAMA, describing the frequency and presentations of UBA1 variant. 
Why not end your patient visit with a recitation pledging your service and commitment:
"Your coming to see me to day is

Dr. John Cush RheumNow

3 years 7 months ago
Why not end your patient visit with a recitation pledging your service and commitment: "Your coming to see me to day is very important, to the both of us. I pledge to be of service to you. Together WE can certainly improve your health" https://t.co/9U95LoiDQi https://t.co/dMWunEXjWk
Recent NEJM has reviewed arthroplasty-associated infection and PJI, noting this is a rare event; notably these infection

Dr. John Cush RheumNow

3 years 7 months ago
Recent NEJM has reviewed arthroplasty-associated infection and PJI, noting this is a rare event; notably these infections are caused by skin microorganisms introduced during arthroplasty surgery or may be seeded post-surgically. https://t.co/DXflkGnsdK https://t.co/GgfeSSl4xJ
A new blood test that can identify progression of osteoarthritis in the knee is more accurate than current methods, providing an important tool to advance research and speed discovery of new therapies.
JAK-pot Study: To Cycle or Switch after JAK inhibitor Failure?

Data from 17 international registries suggest that for

Dr. John Cush RheumNow

3 years 7 months ago
JAK-pot Study: To Cycle or Switch after JAK inhibitor Failure? Data from 17 international registries suggest that for RA patients failing their first JAKi, it did not matter if they were cycled to another JAKi or switched to a bDMARD. https://t.co/xLZveIoaRG https://t.co/tBpJUgOqaN
Burden of BMI on Costs of Musculoskeletal Diseases

A cross-sectional global study shows a substantial impact of obesit

Dr. John Cush RheumNow

3 years 7 months ago
Burden of BMI on Costs of Musculoskeletal Diseases A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders. https://t.co/EZJTnLeaOZ https://t.co/sAOQ3fuq8Z
Subanalysis of Scleroderma Lung Study II (MMP vs CTX in SSc-ILD) showed pt reported GI reflux (~moderate) was independen

Dr. John Cush RheumNow

3 years 7 months ago
Subanalysis of Scleroderma Lung Study II (MMP vs CTX in SSc-ILD) showed pt reported GI reflux (~moderate) was independently associated with the change ILD and fibrosis over two years (but not so for esophageal dilation) https://t.co/6wRCM0PW2a https://t.co/uc2dfdnlhu
I wanted to complain about patients who complain, but guilt and common sense took over. I intended to declare the problem to primarily belong to the doctor, rather than the patient. To me, the solution to the patient’s consternation should begin and end with the source: me (you). My introspection, reasonings, and commandments were fine, but I kept running into the enigma of “Trust” – which can either be a speed-bump or chasm in our physician-
Free read review of IL-15 - crucial for the homeostasis of NK & memory CD8 T cells; IL-15 dysregulations are importa

Dr. John Cush RheumNow

3 years 7 months ago
Free read review of IL-15 - crucial for the homeostasis of NK & memory CD8 T cells; IL-15 dysregulations are important autoimmune Dz & hematological malignancies. How to target the actions of IL-15 are discussed https://t.co/yUuUIOCAC6 https://t.co/nLnC37GdMS
FDA oversees US drug sales, the largest single market for pharmaceuticals globally, worth an estimated $528 billion in 2

Dr. John Cush RheumNow

3 years 7 months ago
FDA oversees US drug sales, the largest single market for pharmaceuticals globally, worth an estimated $528 billion in 2020 in public and private spending (Figure 1). https://t.co/DMwoYIIyHP https://t.co/9nGStaotrO
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