Muscles And Tendons In RA - Dr. David Liew Save
Dr. David Liew from EULAR2020 Virtual Conference
RA beyond the joints - Tenosynovitis as a predictor, MRI and muscle changes in RA
Transcription
Hi, I'm David Liu reporting for rheumnow.com on July 2020, the virtual conference, which was meant to be in Frankfurt, but is now wholly online. I just wanted to bring to you, some of the, RA abstracts, and particularly looking at things beyond the synovium. So in this case, looking at at tendons and muscles. So the first abstract is actually, regarding the idea of tenosynovitis. We know that tenosynovitis is part of rheumatoid arthritis even if it's not just an arthritis.
It's also a disease of tendon inflammation as well. And there's been plenty of great work done in the past looking at imaging studies and picking up tenosynovitis and tenosynovitis doing great things in terms of predicting rheumatoid arthritis outcomes. Well, this Argentinian study looked at ninety patients who had been in remission for greater than three months and did ultrasound at baseline and then tried to see what factors on that predicted future outcomes in terms of flares in the next one year. And surprise, surprise, tenosynovitis outperformed, synovitis by some distance. Subclinical synovitis actually did not predict future flare, where subclinical tenosynovitis had an adjusted odds ratio of over nine.
So really quite powerful stuff. Certainly don't underrate the tendons. Another thing not to forget about is muscle in rheumatoid arthritis. Now, it's a combination of the disease process itself and the inflammation that surrounds it, or it's a product of our medications, we see changes in the muscle. I think what's particularly telling was there was some particularly telling stuff in terms of timing of when this comes about in work from Leeds, from Ireland Tan's group looking at she's got an interest muscle, in rheumatoid arthritis and did some very interesting, work looking at MRI scans and the changes that might be seen on MRI scans, across the course of rheumatoid arthritis and comparing that to healthy controls.
And what's clear is that from the outset, before we even start to get our therapy having an effect on muscle, we can see changes in the muscle. Now those changes evolve and develop over the course of rheumatoid arthritis. And exactly what that means is hard to say, but we can't be flippant about the changes that happen to muscle in rheumatoid arthritis. They're fairly clearly there. And really, think it's the kind of thing that we need to start thinking about how can we target therapies?
How can we look at outcomes and target therapies to make sure that muscle stays intact? Because that's probably something that's affecting the function for our rheumatoid arthritis patients. So great work looking at both the tendon and the muscle in rheumatoid arthritis as well. And I think as we start to get better and better with rheumatoid arthritis, those are the kind of things we need to start thinking about beyond the joint. I'm Dave O'Leary.
And once again, for more information, go to rheumnow.com.
It's also a disease of tendon inflammation as well. And there's been plenty of great work done in the past looking at imaging studies and picking up tenosynovitis and tenosynovitis doing great things in terms of predicting rheumatoid arthritis outcomes. Well, this Argentinian study looked at ninety patients who had been in remission for greater than three months and did ultrasound at baseline and then tried to see what factors on that predicted future outcomes in terms of flares in the next one year. And surprise, surprise, tenosynovitis outperformed, synovitis by some distance. Subclinical synovitis actually did not predict future flare, where subclinical tenosynovitis had an adjusted odds ratio of over nine.
So really quite powerful stuff. Certainly don't underrate the tendons. Another thing not to forget about is muscle in rheumatoid arthritis. Now, it's a combination of the disease process itself and the inflammation that surrounds it, or it's a product of our medications, we see changes in the muscle. I think what's particularly telling was there was some particularly telling stuff in terms of timing of when this comes about in work from Leeds, from Ireland Tan's group looking at she's got an interest muscle, in rheumatoid arthritis and did some very interesting, work looking at MRI scans and the changes that might be seen on MRI scans, across the course of rheumatoid arthritis and comparing that to healthy controls.
And what's clear is that from the outset, before we even start to get our therapy having an effect on muscle, we can see changes in the muscle. Now those changes evolve and develop over the course of rheumatoid arthritis. And exactly what that means is hard to say, but we can't be flippant about the changes that happen to muscle in rheumatoid arthritis. They're fairly clearly there. And really, think it's the kind of thing that we need to start thinking about how can we target therapies?
How can we look at outcomes and target therapies to make sure that muscle stays intact? Because that's probably something that's affecting the function for our rheumatoid arthritis patients. So great work looking at both the tendon and the muscle in rheumatoid arthritis as well. And I think as we start to get better and better with rheumatoid arthritis, those are the kind of things we need to start thinking about beyond the joint. I'm Dave O'Leary.
And once again, for more information, go to rheumnow.com.
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