Treat to target 🎯 #SLE #recommendations Considerations are nuanced and Impt Lowest clinical disease activity is goal Try for remission 🎯 Get patients off #glucocorticoids If not ⬇️low dose #prednisone @RheumNow #LUPUS2025 https://t.co/HlBeh2FLxP

Lupus QD Clinic - Rhupus dsDNA+ SLE Plus CCP+ RA = Rhupus https://t.co/lyV7fgd1vp https://t.co/Ptw0dmyqCj

Lupus in an empty house The full house immunofluorescence pattern is the classic histopathologic finding of lupus and lupus nephritis. Glomerular deposits staining for IgG, IgA, IgM, C3 and C1q can help confirm a suspected diagnosis of systemic lupus erythematosus (SLE). This https://t.co/Zcywc5r9q9

Lupus Unlocked: Pregnancy & SLE 📅 May 27, 2025 6:00 PM CT | 7:00 PM ET | 4PM PT Join us for our final Lupus Unlocked webinar this month on pregnancy and SLE. In this webinar, panelists will discuss issues such as congenital heart block, lupus nephritis treatment, teratogenic https://t.co/gouTN7uzCo

Unmet needs in #lupus are many 👇 Timely #diagnosis Morbidity - CV, metabolic, OP, mental health Premature mortality - CAD, active #SLE, infection Issues w pregnancy #steroid side effects ⬇️QoL With partnerships we can ✅ Pts HCPs researchers Pharma Gov’t #LUPUS2025 @RheumNow https://t.co/9T9rIrM1hV

IL2 low dose in #SLE seems to + alter immune regulation Multiple targets to explore in #lupus Unravelling pathophysiology in SLE CD40L TLR7,8 #rapamycin type drugs CAR-T w novel CARS Etc #LUPUS2025 @RheumNow https://t.co/jeycgg4ZhT

>200 genes 🧬 implicated in #SLE Complex indeed! And ▶️ 7 clusters of signalling pathways So we have to have many Rx options Ab patterns vary LN flares can have v diff pathways between Pts #LUPUS2025 @RheumNow Unravelling #LUPUS2026 https://t.co/LEKN363194

We are not (yet) in #SLE Getting 👇 Correct drug In right pt At right time At correct individual dose Even more problematic is in a renal bx - 2 glomeruli beside each other have v different cytokine expressions Unravelling #LUPUS2025 @RheumNow https://t.co/yGBvhFkPKY

Here’s who flares in #SLE least to most Persistently neg antiDNA Persistently + antiDNA conversion of neg to + antiDNA So are we over ordering antibodies in 1st 2 groups 🤷‍♀️ Unravelling #LUPUS2025 @RheumNow https://t.co/1Feau7f199

controversy re 👇 Monitoring for +Ro pregnant re #congenital #heart #block 87% Y echo is possibly too late No ideas if flourinated #steroids work But many thing we should do something Guidelines differ on recommendations Would fetal home HR be better #LUPUS2025 @RheumNow https://t.co/MY0oPjLnGs

An excellent presentation from Dr Pankti Mehta @PanktiMehta24 Re #Jaccoud’s With #IFN signature if #erosive IA - often + CCP / RF Vs nonerosive often +RNP @RheumNow #LUPUS2025 https://t.co/y6z4KbhCdy

The ANA pattern I hate #DFS Why Dense fine speckled should R/O #SLE But mimicking patterns that MAY Have #lupus AC-2 pattern mimickers ex AC-4 Machine learning models to help ▶️improved accuracy Fast saving hrs #Artificial #intelligence May Choi #LUPUS2025 @RheumNow https://t.co/9tk80ZOAWg