Neuropsychiatric manifestations in SLE. Susanne Benseler MD @RheumNow #ACR24 https://t.co/subiykC5Q4

A#2586 EBIO study - secukinumab on entheseal bx in PsA. Compare b/l to 3+ mo on SEC Biopsy: change of entheseal cell composition on IL-17A Rx - decr Il-17A producing cells in responding pts Spatial transcriptomics - colocalizarjon of ILC2, CD200+ fibroblasts @RheumNow #ACR24 https://t.co/kMiqpBRxuE

Neuroimaging is done to support the diagnosis of CNS #lupus but only 75% reveal abnormal brain MRI. 📌 It is more useful in pts with local deficits than diffuse. 📌 poorly correlated with cognitive dysfunction & psych phenotypes. @Rheumnow #ACR24 @rheumarhyme @theactiverheum https://t.co/HjNbVBaOHv

The different NPSLE syndromes 👇 Highlighted in yellow are the most common manifestations. 🧠 - Cognitive dysfunction - Mood disorder - Anxiety disorder @RheumNow #ACR24 https://t.co/1I7OVPT6DK

A higher number of axSpA pts enrolled in BE MOBILE 1&2 who were treated with BKZ achieved remission accdg to the OSI vs. ASDAS ID (40.5% vs 15.2%) at wk 16 until wk 52. OSI a better measure of remission? @RheumNow #ACR24 abs2362 https://t.co/GCHjXQi9S9

Diagnostic work up for neuropsychiatric SLE. Zahi Touma MD @RheumNow #ACR24 https://t.co/zLX1QHCaSu

Dr @ZahiTouma discusses the attribution rules for the NPSLE syndromes Attribute to #SLE if - onset of NP is near the SLE dx - absence of concurrent nonSLE factors - ⬇️ frequency of NP events in the gen pop'n - diagnostic tools favor NPSLE @RheumNow #ACR24 https://t.co/e1xBK4Xzsw

Very informative slide describing the 2 NPSLE pathogenetic pathways & their differences in mediators, mechanisms and NP events. @RheumNow #ACR24 @rheumarhyme @theactiverheum https://t.co/D3XFDqxMBq

Walsh et al. Direct mailing of PEST questionnaire to psoriasis patients. 13% PEST+, 4% seen by rheum (to date). 75% deemed appropriate for rheum to see - breakdown in picture. @RheumNow #ACR24 Abstr#2635 https://t.co/vlGJ977SV7 https://t.co/dbDUpwDZxy

Sharma @Amansharmapgi et al. DADA2. Clinical manifestations of 101(!) patients. @RheumNow #ACR24 Abstr#2647 https://t.co/Tkk6Rz6rtT https://t.co/frvFPYy4xf

A#2647 DADA2 cohort 101 pts in India Median delay dx 5 years - 5 pts of >20 yr - 39 pts w GI involvement- bad outcomes Skin most common - largely livedo, then ulcers/nodules CNS common w ischemia Many Rx before dx 12 deaths (11.8%) - 8 GI, 3 CVA, 1 suicide #ACR24 @RheumNow https://t.co/Q8kiVbJq8I

A call to action in diagnosing and treating NPSLE 👇 Wonderful talks by Dr @ZahiTouma Dr. Betty Diamond and Dr. Susanne Benseler @Rheumnow #ACR24 #lupus https://t.co/046ArRMP1a