Now we have GWAS, we are getting polygenic risk scores for RA, and we can see what disease risks cluster with RA risk. RA genetic risk clusters with risk for: type 1 diabetes thyroiditis multiple sclerosis What draws these diseases together? #ACR24 ABST1365 @RheumNow https://t.co/28gU1nBEUG

Upadacitinib in Behcet's disease - would be very much welcomed, and this open label 8 patient pilot from China is encouraging. We saw similar data for tofacitinib before @ARD_BMJ: https://t.co/YlAQVXpnTY JAKi (?generic) could be a fantastic option! #ACR24 ABST2515 @RheumNow https://t.co/65friNLUOK

Effective RA therapy is about more than just joints 🇪🇸 RA cohort TNFi for first 24w led to: Lean mass index i.e. muscle going up Fat mass index i.e. fat trending down Muscle & fat composition are important Systemic Rx can deliver systemic benefits #ACR24 ABST1348 @RheumNow https://t.co/mZjcHwxMgW

Steroids in checkpoint inhibitor rheumatic irAEs need to be approached with caution. Persistent higher doses earlier on might dampen ICI response. @HSpecialSurgery ICI-IA (inflamm arthritis) cohort big diff in survival based on early steroid exposure #ACR24 ABST1989 @RheumNow https://t.co/3WAZ3ZLbFw

Dentition is important in RA, but it's easy to forget it's a matter of life or death. NHANES data shows fewer teeth strongly correlates with higher mortality (esp cardiovascular). Missing teeth = CV death HR >30 Holistic dentition is holistic RA care #ACR24 ABST1325 @RheumNow https://t.co/Z40bSFybuS

Rheumatic irAEs can get on the CAR-T bandwagon, too! CAR-T can invoke new rheumatological issues (not just cytokine release) - see @DrGomezPuerta's experience. Infrequent, but if CAR-T in general becomes common, yet another job for us to attend to... #ACR24 ABST2004 @RheumNow https://t.co/xBSlhUdkNr

Now that nipocalimab is approved for Sjogren's Disease, what about vaccination response whilst on this FcRn inhibitor (inherently lowers IgG)? Actually, not bad: takes a little longer to get there, but reassuring! (always fun to get to know a new med) #ACR24 ABST1988 @RheumNow https://t.co/IYqIGo5xVP

Active early RA accentuates regional MSK pain. Non-articular pain: easy to ignore & focus on active RA yes, some is related to RA dx activity BUT actually it becomes a bigger issue over time Worth identifying to: clarify what isn't RA Rx appropriately #ACR24 ABST1335 @RheumNow https://t.co/iN5rsyr7Bx

Here's a meta-analysis of MACE/malignancy in JAKi vs TNFi in observational cohort studies. All the epidemiological challenges here aside, it's a good reminder that with ORAL Surveillance it's *cardiovascular risk enriched pts* we're concerned about. #ACR24 ABST2264 @RheumNow https://t.co/vIXlrI3V2d

Post hoc analysis of SPIRIT H2H evaluated nail involvement as a measure of ttnt response in PsA. -Pts with nail involvement treated with IXE or ADA had higher SJC and TJC improvement vs those without involvement at W12, W24 and W52. -IXE achieved rapid response for DAPSA-LDA as… https://t.co/SR36qCthQo https://t.co/hI3tD5hATJ

3D management of Sscl from @delgaldoFrances -Time -Severity -Type of organ involvement *Identify phenotypes: fibrotic vs vascular damage. *Raynaud’s red flags: +ANA, puffy fingers, abn capillaroscopy. *Early ttnt of of digital ulcers delays onset of PAH. *High IFN-I =marker of… https://t.co/ByfuV0MJds https://t.co/GdRVwuRf4E