Guselkumab maintenance dose is 100 mg sc q8wks. GUIDE ph 3b trial treated 297 PSO super responders (PASI <3) w/ q8wk or extended q16wk GUS & demonstrated noninferiority of q16 wk dosing w/ disease control (91.9 vs 92.6%) https://t.co/31DPTmcVD2 https://t.co/qHMsyYCH4J

Review of Calcium Pyrophosphate Deposition Disease Lancet Rheumatology has published a review of Calcium pyrophosphate deposition (CPPD) disease - a chronic inflammatory and degenerative crystal arthropathy that increases with aging. https://t.co/svIGF3hM0Y https://t.co/17CNkOiGPB

NSAIDs Used Despite Contraindications https://t.co/elhnmB3N52 https://t.co/VgIqKvkfVJ

Arthritis drugs may relieve long COVID lung symptoms University of Virginia SOM researchers have identified a potential treatment for the respiratory symptoms of long COVID after discovering an unknown cause of the condition inside the lungs. https://t.co/4gqVhzOEMg https://t.co/NEysSjRE8c

US Childrens Hosp Admission database finds 8588 kids w/ SLE & ≥ 1 hospitalization; 13% for infections, w/ Bacterial pneumonia most common. cSLE In-hospital mortality in 0.4%, but 2% for infection. Highest mortality w/ PJP (21%), fungal infx (21%) https://t.co/fmyRXagCcD https://t.co/yXDMFYhhdP

Full read review of tendinopathies - triggers (mechanical, intrinsic, extrinsic), biology, biomechanics & repair. Despite multivariable biologic disruptions, tendinopathies is mostly restricted to symptomatic therapy. https://t.co/h2D3fbUNVO https://t.co/2rmw6E0F6Z

Cohorts of 100 compared PsO/PsA pts to controls. Psoriatic pts had significantly more cases of polyneuropathy than controls (RR ~20), but the significance was lost when corrected for frequent comorbidities that cause neuropathy https://t.co/ujPlgmISUc https://t.co/aNLaJMDhvM

CHECK: a prospective cohort study shows that Femoroacetabular impingement syndrome in is strongly associated with the development of radiographic hip OA (RHOA) within 10-yrs (OR 6.85 for incident RHOA and OR 47.82 for end-stage RHOA) https://t.co/Kt0bsIdpnS https://t.co/mSGRbQV4vI

TRUST: 10 Yr Japanese study of tacrolimus in 1355 SLE nephritis pts; half on TAC x 10yrs. TAC use assoc w/ signif reduction corticosteroid use (~16 mg/d @4wks to 7.2 mg/d @ 1Yr(P < 0.001). 9.7% w/ serious AEs. https://t.co/PsfCVZF4tk https://t.co/l3HkTRc4oC

Elder adult Cohort study of 2413 women & 792 men w/ hip BMD-defined osteoporosis based on CT scans, shows 30% of women & 34% of men had hip Fx. Rx w/ alendronate (34%F; 24% M) signif lowered Fx rates (aOR 0.26 and 0.21, respectively) = no sex difference https://t.co/briuZAYVKx https://t.co/xrZ12TmMvM

Literature review - Glucocorticoid use in elderly to be problematic. GC use may be assoc w/ remission, but GC increases AE rates, & there is difficulty w/ GC discontinuation. Goal: D/C GC early, but some may require for up to yrs to control Dz activity https://t.co/6liN0mubIv https://t.co/PiGKGSYrof

New Classification Criteria for Juvenile Axial Spondyloarthritis An expert panel has published new and validated classification criteria for axial disease in children with juvenile spondyloarthritis (SpA; AxJSpA). https://t.co/kxtHlEk5XG https://t.co/jKAp9W5Di1