#Editor’s #Choice @MatsJunek Who #relapses in #ANCA #vasculitis In #Pexivas trial #Renal #failure may be protective from relapses. Seems to be the case in renal #lupus #GN too~my opinion ?Why 🤷 #EULAR2024 #EULARBEST @ARD_BMJ @RheumNow @eular_org @ACR_Journals https://t.co/kUD1qjnwqE

I was allocated to bring down the warning, & I did apologise up front to both the EMA and Janet #EULAR2024. It's a tough gig regulating impactful medicines with risk-benefit, especially when our world is full of other medicines with risk-benefit trade-offs (like prednisolone). 2/ https://t.co/6YPhYHbhg8

So how do we get from slightly increased numbers of uncommon events in a single study (ORAL Surveillance)? Regulators think differently to us, which partly is the difficulty of a restrictive warning. So being the Aussie I am, I asked - does it pass the 'pub test'? 4/ #EULAR2024 https://t.co/Ih9H87wH22

Having said that, the EMA warning has elements making it extremely tough: - still very broad criteria that capture 80% of people who were starting JAKi - the need for "no suitable treatment alternatives" before using a JAKi, right across all diseases (not just RA) 3/ #EULAR2024 https://t.co/IsrYO7qzqM

So I think there is plenty we could do instead. better regulation better risk stratification better counselling better risk factor management (and definitely read this if you want to be a good clinician: https://t.co/RA6ktQB7gm) 18/ #EULAR2024 https://t.co/bC5nmi8SoM

My friend the late, great @philipcrobinson and I wrote @TheLancetRheum about what we could learn from COVID about preventative medicine. https://t.co/55j8rduvyn It's worth us thinking how we can do better by our patients. 18/ #EULAR2024 https://t.co/zlDKYngsu0

Here's my 'pub test' for whether the warning is appropriate. And, debate aside, I do believe that it behoves any regulator to consider the unintended consequences of their regulation, because regulation has real consequences. 5/ #EULAR2024 https://t.co/aurbAwgl9P

The original direct comparison study! https://t.co/hqrPKfNW1y

https://t.co/H8TijO4UUV

Computer vision/ image analysis is performing very well in rheumatology and can extend help to low resource settings easily! #EULAR2024 https://t.co/8doM7foriM

SLE RPI may be used more frequently and can connect the digital dots! @RheumNow https://t.co/UdVIyZJhJV

Deep learning models are detecting CPPD in radiographs pretty well!! Abst#0112 #EULAR2024 presented by @ThomasHugle ...@RheumNow https://t.co/9z3VVbyyh0