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Re
#JAKi #safety
Shared decision w benefit/risk info
Some #CV risks are more Impt than others- stratify your pt into risk categories
#Smoking is a big risk for #MACE &
#malignancy-So work on facilitating
Smoking #cessation
#EULAR2024 @eular_org @RheumNow
Janet Pope @Janetbirdope ( View Tweet )
1 year 8 months ago
3 facts in #lupus to make you think 🤔
💧biomarkers in #SLE blood & #urine May predict #activity
OP0255
#Membranous #nephritis is serious in SLE @ZahiTouma POS0732
#prednisone dose irrelevant for #damage if in LLDAS -no diff between 7.5mg vs 5mg OP0124
#EULAR2024 @RheumNow
Janet Pope @Janetbirdope ( View Tweet )
1 year 8 months ago
#Hope for patients with #active #SLE
The next hurdle is getting through
▶️Phase3 #RCTs
And
▶️Obtaining drug reimbursement so patients can get access to effective
#lupus #Rx
#EULAR2024
@RheumNow @eular_org https://t.co/sGzQXO4A2r
Janet Pope @Janetbirdope ( View Tweet )
1 year 8 months ago
OP0072 @RheumNow #EULAR2024
Effects of #Upadacitinib or #Adalimumab on pain in #RA
SELECT-COMPARE Phase 3 study
UPA & ADA led to improvements in pain vs PBO
PtGA & TJC28 pain improvement similar between UPA & ADA
➡️ UPA may be more effective in control of pain than ADA in RA
Mrinalini Dey @DrMiniDey ( View Tweet )
1 year 8 months ago
Can we prevent psoriatic arthritis? Highlights from #EULAR2024 that help us understand this topic better @RheumNow https://t.co/E8Wy8FH4oU
Dr. Antoni Chan @synovialjoints ( View Tweet )
1 year 8 months ago
#Vaccinations against #herpes #zoster in #MTX +#Upadacitinib Pts
▶️ #Shingrix works
👍Pts followed to 60 months
#EULAR2024
@eular_org @RheumNow
#OP0020 https://t.co/8ORC3Nd2FK
Janet Pope @Janetbirdope ( View Tweet )
1 year 8 months ago
OP0018 @RheumNow #EULAR2024
🔎 Study looked at early RA patient trajectories through time-independent disease state
📊 Authors demonstrated 4⃣ trajectories in early RA
🦴 Inflammation in joints, blood & poor response are main discriminatory factors https://t.co/IeDIU3jg9B
Mrinalini Dey @DrMiniDey ( View Tweet )
1 year 8 months ago
➡️ OP0064 @RheumNow #EULAR2024
➡️ Non-articular pain (NAP) at early RA diagnosis & evolution over the first yr of RA treatment
➡️ NAP, esp regional NAP, common in early RA during 1st yr
➡️ NAP in axial, both upper quadrants and both lower quadrants common https://t.co/FOGcS05Z25
Mrinalini Dey @DrMiniDey ( View Tweet )
1 year 8 months ago
OP0086 #EULAR2024 @RheumNow #EULARBest
Pain & remission/low disease activity at 3m in pts with #RA in RA-BE-REAL
Pts taking #baricitinib more likely to achieve pain control vs TNFi/other mode of action
1/2 pts achieving remission/LDA & had bari achieved ≥70% pain relief.
Mrinalini Dey @DrMiniDey ( View Tweet )
1 year 8 months ago
TOLERA trial in RA
RTX/ABA sequence versus RTX alone
10pts each group
Primary outcome was ambitious: ACPA seroconversion
No difference between ttmts (and also no seroconversion)
No diff in disease activity
No diff in ACPA change wt wk52
@RheumNow OP0069 #EULAR2024 https://t.co/0EM7XRzfNo
Aurelie Najm @AurelieRheumo ( View Tweet )
1 year 8 months ago
200 millions pts PSO
1st line, Reduction risk PsA: IL 12-23 37% & IL-23 39% vs. TNFi
2nd line ttmt, IL12-23i 32% & IL-23i 31%
IL-23i 47% lower proba PsA than IL-17i 3 & 5 yrs
Can't exclude some channeling bias, but that's a big signal!
@RheumNow OP0010 #EULAR2024 #EULARBest
Aurelie Najm @AurelieRheumo ( View Tweet )
1 year 8 months ago
AMPLIFIED RCT, 300+ pts
ABA NOT (!) superior to ADA
in dual seropositive SE+ MTX IR RA pts
ACR50 rate high in both gps ABA 59% vs ADA 64%
No new safety signal
Defeating the encouraging data from smaller trials
Abstr#OP0007 #EULAR2024 @RheumNow https://t.co/PvRUnpthHl
Aurelie Najm @AurelieRheumo ( View Tweet )
1 year 8 months ago
