Lyme Disease 2022 The CDC has updated its Lyme disease surveillance report based on a new case definition. Compared to 2017–2019, the number of cases in 2022 rose by 69%. https://t.co/iCAbSYbhsB https://t.co/7q8hCXV1CZ

Increased Depression on Rheumatoid Arthritis A Korean nationwide cohort study found that both seropositive and seronegative rheumatoid arthritis (RA) patients have a significantly higher risk of depression. https://t.co/9AtlBrDTUJ https://t.co/vKEhBfkHQD

Greek study of 160 #GCA pts (age 72 yrs) - all on Hi dose steroids (GC) @ start, 37% DMARD & 16% biologic. @ 2 Yrs, 42% D/C GC & 27% had Relapses. Predictors of relapse = LG vessel involv (OR=4.2), CV event (4.6) & higher initial GC doses (OR=1.04) https://t.co/FshaslTuSI https://t.co/y9uVgkR58Y

Starting MTX at higher or subcut. doses yields better ACR20 responses. Review of 12 trials & 1,566 pts, shows: - higher initial MTX 25 mg (but more GI AEs) - SC MTX more ACR20 resp (85% vs PO 77%) - MTX non-response, success w/ SC MTX https://t.co/01PuDpkUIF https://t.co/vXLWEp4srH

Japanese study of 96 #SLE pregnancies: 59 in remission @ conception. Remission had fewer adverse preg outcomes (OR 0.27) vs those w/ activity. No difference in APO based on serologies, but Pred ≥7.5/d us had signif. more APO. (OR 3) https://t.co/BvOeiSERN9 https://t.co/ePh1dqdJvS

Polyarteritis Nodosa (PAN): Clinical Features and Outcomes A multinational study of PAN through the international GLOBAL-PAN network shows PAN to be a complex, multisystem disorder with a high risk of relapse and low risk of death (11% at 10 years). https://t.co/cyCzxRnjJf https://t.co/DleD9cYFTb

Frensius-Kabi has announced that the FDA has approved the tocilizumab biosimilar, Tyenne (tocilizumab-aazg); the first TCZ biosimilar with both IV and subcutaneous formulations https://t.co/F3d8DKxpkU https://t.co/NSEqAcoBBo

Review article on inclusion body myositis, a progressive, debilitating myopathy w/ onset > 50 yrs. IBM typically has asmmetric, painless, weakness & atrophy of finger flexors or quadriceps w/ dysphagia. Most are wheelchair bound w/in 13-15 years https://t.co/LoWtmDqimu https://t.co/N3OUU7QMc1

Can Mycophenolate be Stopped in Stable SLE? https://t.co/8oQx0cqDr3 https://t.co/mlt2Qqj8wm

COVIDs Extended Risk for Rheumatic Disease Annals of Internal Medicine reports a large, binational study finding SARS-CoV-2 infection was associated with an increased risk for AIRDs that extends up to 12 months after infection. https://t.co/HjQ56hiiny https://t.co/vvC3iVqNyF

Review of autoimmune Dz & adverse preg outcomes: Incr risk of: - Miscarriage w/ Sjögrens (RR 8.85) & SLE (OR 4.9) - Preeclampsia w/ SLE (OR 3.2) - IUGR w/ scleroderma (OR 3.2) & celiac (OR 1.71) - Preterm birth w/ SLE (OR 2.79). https://t.co/bll2x2aS9Z https://t.co/Eg0sVBcPmR