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High risk medications for pregnancy: MTX- 40% pregnancy loss, 6-10% birth defects MMF/CYC - 40% pregnancy loss, 25% birth defects Recommend 2 forms contraception on MMF Change meds slowly to safe Rx and monitor disease activity at least 3 mos before pregnancy #RNL2024 @RheumNow

Dr. John Cush @RheumNow ( View Tweet )

2 years ago
#RNL2024 @anisha_dua Throwing the kitchen sink in severe GPA CYC + RTX combo - sick population (median GFR 9, 47% on HD, 52% DAH, all received PLEX too) - 85% survival, 69% not ESKD, low rates of relapse (13% at 36 mos) But, prolonged B cell depletion, aggressive Rx

Dr. John Cush @RheumNow ( View Tweet )

2 years ago
Chikungunya arthritis Metanalysis & good full-read review - 8 studies showing chronic arthritis (CCA) in minority of infected;, polyarticular, looks like RA, few seropositive, few w/ erosions on imaging. CCA may be progressive w/ irreversible damage https://t.co/8NdBCGTfxF https://t.co/SLt5COmKVf
Dr. John Cush @RheumNow ( View Tweet )
2 years ago
Hyperpigmentation from Hydroxychloroquine. From 316 HCQ pts, 26% got hyperpigmentation; delayed onset of 12 mos (6–30mos) after median cum. dose of 108 g. Seen on face (602%), Legs (36%) & hands (20%). Daily sun exposure decrease in the incidence (P=0.02) https://t.co/UX8hnwJjhs https://t.co/xU9RWCcr9C
Dr. John Cush @RheumNow ( View Tweet )
2 years ago
RA-ILD at Higher Risk for Serious Infection and Death A prospective, multicenter study from Spain has demonstrated higher rates of mortality and serious infection in rheumatoid arthritis–associated interstitial lung disease (RA-ILD) patients. https://t.co/cjmcNi0ZqL https://t.co/wUXNWNeyOa
Dr. John Cush @RheumNow ( View Tweet )
2 years ago
Lupus Accelerating Breakthroughs Consortium Partners with FDA https://t.co/GW7Zy72oIZ https://t.co/AGYY8WDKcK
Dr. John Cush @RheumNow ( View Tweet )
2 years ago
Retrospective study of hand/feet Xrays in early/suspected #RA due to low prevalence of erosions (4.4%) seldom leading to change in Dx (2pts; 0.3%) or prognosis change (0.4%). Seronegative had less erosions; Longer Sxs not assoc w/ erosions https://t.co/YCj04ZlQJq https://t.co/fHf6EvGOyc
Dr. John Cush @RheumNow ( View Tweet )
2 years ago
BSR Guideline on Management of Sjogren’s Syndrome Sjögren disease (SD) is the most common of all autoimmune disease, yet little is know of its etiology and there are insufficent interventions for those affected with mucosal or systemic manifestations. https://t.co/Y8hNoBmBn3 https://t.co/up5motCwkp
Dr. John Cush @RheumNow ( View Tweet )
2 years ago
Did you know the first clinical controlled trials were done on sailors with scurvy? They were randomized to: a quart of cider, HCl, 2 spoons of vinegar, pint of sea water, spicy nutmeg paste w/ water vs. 2 oranges and a lemon. Guess which sailors fared best? #RheumGR @UTSWRheum https://t.co/fAeCeIxZ9e
TheDaoIndex @KDAO2011 ( View Tweet )
2 years ago
AbbVie announced preliminary positive results from phase 3 SELECT-GCA study showing remission in 46% of #GCA pts Rx w/ upadacitinib for 52wks (vs 29% PBO); RCT included a 26-wk steroid taper regimen https://t.co/lqGVHKw3XF https://t.co/EyLuf8QLZA
Dr. John Cush @RheumNow ( View Tweet )
2 years ago
PJP PPx in AAV @anisha_dua #RNL2024 @RheumNow 919 GPA pts on RTX - only 31% on TMP/SMX 13 pts devel PJP, not on PPx Overall decreased serious infections (HR 0.5), outpt infections HR 0.7 Adverse effects on TMP/SMX 29.6 vs 13.4 For every serious ifn avoided, 2-3 pts will have AE

Dr. John Cush @RheumNow ( View Tweet )

2 years ago
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