Triggers for SLE flare by @Kahlenberglab . Here in Ireland, it is so often UV light (oh its not warm enough for sunblock, its cloudy, I was only out for 20 minutes, etc). We must get our messaging better @RheumNow #RNL2024 https://t.co/0T1oJH8MqJ

Mimics of SLE flare by @Kahlenberglab . They are many, common, and crucial @RheumNow #RNL2024 https://t.co/P7b72T9GS6

Type 1 IFNs are a unique feature that impacts disease – Dr. M Kahlenberg noted innate immune cells & tissue are triggered by UV light, microorganisms, causing changes to the immune system: DC’s and B cells are more active, represses Tregs, drive skin disease. #RNL2024 @rheumnow https://t.co/fXnPIFN6VA

“Flares require a trigger!” – Dr. M Kahlenberg on #SLE flares #RNL2024 @rheumnow https://t.co/rqAnAOfJZP

Is it a lupus flare or a mimic? Fibromyalgia, stress, infection, poor sleep, hypothyroidism, vitamin deficiencies can contribute to pain and fatigue in a patient. – Dr. M Kahlenberg #RNL2024 @rheumnow https://t.co/pLuqyy8gHm

Lupus has many flavors. If we are better able to sort them, we might be more better at finding effective treatments. @rheumnow #RNL2024 @DrDavidKarp https://t.co/rklqnA8Ur6

"SLE affects women in the prime of their life, 25% of pts go to the ER, up to 50% will have lupus nephritis; it is a deadly and costly disease.” - @DrDavidKarp on why we would be focusing on identifying preclinical SLE and preventing the disease #RNL2024 @rheumnow https://t.co/SIZ5ZBwu94

Should we define preclinical SLE as stages rather than using confusing nomenclatures like UCTD, incomplete lupus, etc? - @DrDavidKarp @rheumnow #RNL2024 https://t.co/OjRjdBzJWE

When should you intervene? We talk about primary and secondary prevention... but what about primordial prevention that targets social determinants of health? - @drdavidkarp #RNL2024 @rheumnow https://t.co/UGAcNFLqZf

What early biomarkers are specific for SLE? How many will progress to stage 2? Who should we screen? Will patients revert to pre-stage 1? Is progression preventable? @DrDavidKarp on relevant questions we need to ask regarding preclinical stage 1 lupus. #RNL2024 @rheumnow https://t.co/bJPG68WdyE

Can HCQ prevent SLE? Results of the MONA-LISA study is being analyzed (pts have +ANA and 1-2 SLICC criteria for SLE randomized to PCB or HCQ) - @DrDavidKarp @rheumnow #RNL2024 https://t.co/9yoFXS7wMe

#RNL2024 @RheumNow @DrDavidKarp Incomplete lupus is heterogeneous term "Stage 2" pre-classification stage as ILE/UCTD Stage 1: non-specific antibodies, dysregulation 2: incomplete features 3: classified, multi-system disease 4: irreversible tissue damage https://t.co/CuLUzSZ24E