“Less than 20% of low +CCP patients who are asymptomatic will develop RA over 5 years” – Dr. Gabalawy recommends lifestyle changes (STOP smoking, Mediterranean diet, exercise) ; a substantial proportion will revert to ACPA neg state #RNL2024 @RheumNow https://t.co/yyHwVZWOf0

Why should we care about preclinical RA? Goal: to treat once and stop the trajectory of the disease. – Dr. Gabalawy #RNL2024 @rheumnow https://t.co/afbpvrZV8v

<20% of anti-CCP+ pts without arthralgia with develop RA in 5 years! Dr. H. Gabalawy #RNL2024 @RheumNow https://t.co/OXe7EWfCmc

#RNL2024 @RheumNow TREAT-EARLIER - MTX for Clinically Suspect Arthralgias No overall diff vs PBO High risk pts had benefit, but not sustained at 2 yrs But sustained reduction in HAQ & MRI inflammation - Signs for hope? Overall, prevention studies have been disappointing https://t.co/DtBlGaw0Lf

Rheums are "all over the map" but tend to skew conservatively when treating pre-clinical RA. Dr. H Gabalawy discusses the results of a case-driven polling question at #RNL2024 @RheumNow. Be sure to register at https://t.co/DXQ0KCelIh to hear his, and other, lectures to weigh… https://t.co/Yo3ChNwNIO https://t.co/wD3AMUDNr9

“At 2 years, 50% of patient with +RF/+CCP Ab will develop RA, at 5 years, 70%” – Dr. Gabalawy on can we predict who will get RA, is there a point of no return, can we prevent the progression #RNL2024 @rheumnow https://t.co/G8Rxd3CAoi

Seropositive RA is a spectrum to disease Hani El Gabalawy @RheumNow #RNL2024 Genetic and environmental factors affecting autoimmunity and leading to disease Clinical suspect arthralgias usually finds "imminent RA", may be too late at that stage for prevention https://t.co/mGclCr3cth

Dr. Hani Gabalawy shared his pre-clinical stages of seropositive RA --Break in the immune tolerance > pathogenic autoimmunity > RA Unknowns: timeline, can we arrest pre-clinical stages, etc? #RNL2024 @RheumNow https://t.co/8cMNGKM4rk

Using diet to shape the microbiome and to improve outcomes in inflammatory arthritis and response to medication. An anti-inflammatory and Mediterranean diet can help improve outcomes in RA, Monica Guma #RNL2024 @RheumNow https://t.co/x64Tbseuvz

"The gut microbiome may affect how patients respond to their therapies" - Dr. Guma another reason why diet is important #RNL2024 @rheumnow https://t.co/7qI72HWRg0

“Even a cookie changes the gut microbiota!” – Dr. Guma showing dynamic microbiota changes to the food we eat and even to the medications we take. #RNL2024 @rheumnow https://t.co/5d6Ld39BzG

Monica Guma at #RNL2024 @RheumNow How does Mediterranean diet help inflammation? Maintains healthy microbiota Enhancing production of anti-inflammatory metabolites Maintains intestinal barrier integrity https://t.co/CyzTGBJzhm