Since 2010, use of RTX has increased & AZA decreased in GPA/MPA. French national insurance study of 977 GPA/MPA in 2010-12 vs 1131 GPA/MPA in 2014–2017 saw incr RTX, decr AZA, but stable use MTX, CTX, steroids over time https://t.co/ICtDqxthAN https://t.co/bFvOL3GGmf

Alot of murky "research" on Platelet-rich plasma (PRP). This RCT of120 pts having anterior cruciate ligament reconstruction (half randomized to PRP) shows no PRP benefit, no significant improvement of knee symptoms & function post ACLR https://t.co/qscBvywWLS https://t.co/jSohaMhBnY

Retrospective cohort study compared 5825 #AS pts vs 28,356 matched controls; showed an increased risk of pulmonary embolism w/ AS; not present pre-Dx ((0.4% vs 0.2%), but incr post-AS Dx (PE IR 11.6 vs 6.8/10KPY: adj HR 1.70;; p<0.001) https://t.co/Tsd77iUsjC https://t.co/sd6wbtuaqw

In animal models, IL-22 may have protective effects against pulm fibrosis. Study of 66 new #RA pts (1/2 w/ ILD) & 14 controls. Serum IL-22 was signif lower in RA-ILD; and was inversely correlated with the severity of RA-ILD https://t.co/Rmr5N2JznH https://t.co/OZ1ZrgGXC3

K Kuhn et al: Altered tryptophan catabolism by microbiome may contribute to inflammatory arthritis. Tryptophan increases indole leading to ncreases in serum IL-6, TNF, and IL-1β; splenic RORγt+CD4+ T cells, & IL-23 and IL-17 production https://t.co/Bqm5ecvGR5 https://t.co/O1jCSqFICr

The EMAs CHMP has recommended for approval Two biosimilars, Tofidence (tocilizumab) and Wezenla (ustekinumab) https://t.co/mREclYdeCk https://t.co/zQX00Ys8oH

MGH study compared 1148 acute CPPD vs 3730 controls (mean 73 yrs) found 2 fold more fractures (mostly wrist); 11.7 vs 5.5/1000 PYs (HR 1.8) in pseudogout pts (also had more steroids & OP) https://t.co/HhCV6fYubF https://t.co/3bcbvSzzPo

Substitute Measures of Inflammation (many dervied from the CBC) https://t.co/rYBqrNH8Zo https://t.co/Fa1mC17ErJ

RECIPE Study: Non-opioid Analgesics following Total Hip Arthroplasty Patients undergoing total hip arthroplasty using a combo of paracetamol, ibuprofen, + dexamethasone, had optimal responses with the lowest morphine consumption, & fewer adverse events. https://t.co/PXmPGscwu3 https://t.co/2Lse0gNx70

RISE study of 700 Pegloticase users (14 mos F/U) found 18% on immunosuppressive (MTX, MMF, LEF), these had signif less PEG D/C (HR 0.52-0.69). Immunosuppressives not assoc w/ more lab abnormalities https://t.co/4ytot7HOMh https://t.co/0wrjvnZur3

PI states risk of GI Perforations (GIP) incr w/ IL-6i (1.1--2.6/1000PYs) & JAKi (~1-2/1000PY) . French Insurance pop. study of ~40K pts on JAKi or adalimumab found NO no signif difference betw JAK v ADA (IR: 2.1 vs 1.1/1000PYs; p=0.65). https://t.co/YlxiBOhNFj https://t.co/A5hMbWDXeV

NEJM: evolution of pyoderma gangrenosum skin lesions https://t.co/wE9pAZZs9L https://t.co/jTijcCvpfI