Machine learning of 701 Anti-Synthetase (Anti-Jo1, -PL7, -PL12, -EJ) identifies 3 Endotypes,independent Ab specificity #1 (24%) w/ RP-ILD & high mortality #2 (14%) dermatomyositis, intermediate prognosis #3 (62%) arthritis & mechanics hands, good prognosis https://t.co/4NqZp4yR18 https://t.co/rBrhBxxniR

ICYMI: Community-Acquired Pneumonia (CAP) https://t.co/AMConIb14r https://t.co/BCfcHc5i37

Have a Rheumatology question or case for Jack Cush? Record it here and we'll feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/a3XeAa2lcG https://t.co/dTZa2uQF97

Polyautoimmunity in RA, Regardless of ACPA Positivity While it is believed that autoimmunity follows autoantibody positivity, a Danish study shows the incidence of polyautoimmunity to be similar in RA patients who are either ACPA + or -. https://t.co/7lmp1NB0XX https://t.co/onaEluzkGy

19% Arthritis Prevalence in the US According to NHIS, in 2022, the prevalence of diagnosed arthritis in adults was 18.9% . These numbers are down since the CDC's MMWR report of 2019–'21, where it was estimated 21.2% of U.S. adults had "diagnosed arthritis" https://t.co/mtYSBHw8Oo https://t.co/NHqjLlwatm

Frensius-Kabi has announced that the FDA has approved the tocilizumab biosimilar, Tyenne (tocilizumab-aazg); the first TCZ biosimilar with both IV and subcutaneous formulations https://t.co/cdSVbuBzXf https://t.co/CUC5v0hSxr

Fibroblast activation w/ inflammatory arthritis studied by PET to detect fibroblast activation protein (FAP), but decreases after TNF or 17A inhib. Fibroblasts switch from pathogenic (MMP3+/IL6+) to pro-resolving phenotype (CD200+DKK3+) https://t.co/K1xAMqPiuT https://t.co/07NNgW9Lpv

Review article on inclusion body myositis, a progressive, debilitating myopathy w/ onset > 50 yrs. IBM typically has asmmetric, painless, weakness & atrophy of finger flexors or quadriceps w/ dysphagia. Most are wheelchair bound w/in 13-15 years https://t.co/jybZzCDYk5 https://t.co/FyVA5hveZ4

ICYMI: Teaching and Academic Burnout RheumNow recently highlighted a publication that reported about a third of physicians in academia intend to leave. https://t.co/uSVVJ6zl73 https://t.co/6BWwd2btMf

Preoperative Delay & Education Benefits Arthroplasty Patients A randomized study shows having patients waiting for knee arthroplasty undergo a preoperative program of weight loss, exercise, etc gave them modestly improved pain/function/quality of life. https://t.co/RSFwhFKq8U https://t.co/xgyQ65mUAO

Stills Dz Rx w/ IL-1 or IL-6 inhib may mask Dx of MAS! Study of 162 systemic JIA & MAS (62 on biologics). Biologic Rx pts had lower Plt, Ferritin (1107 vs 2863(, CRP (15 vs 90), ESR, fever duration. 27% on IL1/IL6i did not meetMAS classification criteria https://t.co/RmAzxh459R https://t.co/SXroqNBLSZ

Can Mycophenolate be Stopped in Stable SLE? https://t.co/cDmarnHjAN https://t.co/YgG1jbP4Pw