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#CAR T cells #ACR23
🔥Back to back Sessions on one of the most avidly researched area in Rheum!
💡Check out these slides to understand:
☣️Toxicities and Limitations of CAR T therapy
🆕 Novel CAR designs
⚡️CAR cell sources
❓Research Questions to ponder!
#ACRambassador https://t.co/6sOn4rjqY3
debaditya_roy ( View Tweet )
2 years 3 months ago
Toxicities and limitations of CAR therapy:
the other side of its incredibly exciting, boundless potential
@Michel_Sadelain @MSKCancerCenter #ACR23 @RheumNow https://t.co/L1UIqqlOdC
David Liew @drdavidliew ( View Tweet )
2 years 3 months ago
Congrats to Dr Kaitlin McCarter for her #ACR23 investigating predictors and mortality of pre-existing RA flare after immune checkpoint inhibitor.
46% flared
Seropositive- OR 2.0
NO association with mortality
-ICIs are safe to use in RA
-Flares are not a proxy of efficacy https://t.co/eoy0FJb1nA
Jeffrey Sparks MD MMSc @jeffsparks ( View Tweet )
2 years 3 months ago
Conundrum of #Clinically #Quiescent #Serologically #Active #SLE-half flare within 5 yrs; can have organ damage. Large cohort-China
20% met def’n- diff trajectories
37% flare
1/6 got damage in f/u
Some tapered Rx
How to identify safe to d/c Rx?
2555 #ACR23 @ACRheum @RheumNow https://t.co/f49BQspQsz
Janet Pope ( View Tweet )
2 years 3 months ago
Are all ICI-IA irAEs the same?
@cappelliMD @jhrheumatology presented lovely work: latent class analysis on her cohort data
She found two phenotypes - one with more persistent symptoms, & potentially a start in stratifying irAE therapy going forward.
#ACR23 ABST2513 @RheumNow https://t.co/roW00KwbVZ
David Liew @drdavidliew ( View Tweet )
2 years 3 months ago
Patella tendon characteristics with USG - thickness, cross sectional area and stiffness measures with shear wave elastography
In pts with or without knee pain
@rheumnow #ACR23 52 pts Pain didnt correralate with thick ess and cross sectional area but did correlate with stiffness https://t.co/q3ZPG1l2n2
Bella Mehta @bella_mehta ( View Tweet )
2 years 3 months ago
Plenary Abs #2425: Pregnancies among vasculitis pts - higher frequency of spontaneous abortion and preterm delivery. Risk of maternal complications associated with vasculitis were observed to vary by vessel size and parity. #ACR23 https://t.co/qLcpNapcjg @rheumnow https://t.co/sk3dhySVfP
Dr. Rachel Tate ( View Tweet )
2 years 3 months ago
LNK01001 12 mg or 24 mg BID to 24 weeks in moderate to severe RA achieved ACR 20 (91.1%, 90.7% respectively), were generally safe, well tolerated with most TEAEs being mild to moderate. Effect seen in Week 1. Wu C, Late breaking Abst#L09 #ACR23 @RheumNow https://t.co/M29LYtEs9I
Dr. Antoni Chan ( View Tweet )
2 years 3 months ago
AutoAb and irAE?? Really only associated for thyroid dysfunction. For ICI-IA we need different bio markers #ACR23 https://t.co/Fc24y8TzJv
Laura Cappelli ( View Tweet )
2 years 3 months ago
Congratulations to Mount Sinai medical student and mentee Celestine He, on being awarded a Rheumatology Research Foundation Medical Student Preceptorship Award. Very proud of you and your excellent work! 👏🏻👏🏻👏🏻
#ACR23 @celestinejhe @MSRheumatology @IcahnMountSinai https://t.co/F078eSnL9p
Chrisanna Dobrowolski ( View Tweet )
2 years 3 months ago
Our collaborative study on nirmatrelvir-ritonavir (Paxlovid) virologic rebound is out in @AnnalsofIM @DrJLi @zach_wallace_md
-Paxlovid: 21% with rebound vs. 2% in untreated (OR 10)
https://t.co/RRDxerGdBy
Jeffrey Sparks MD MMSc @jeffsparks ( View Tweet )
2 years 3 months ago
US adults with #gout had higher 10-year all-cause mortality rates than those without
Premature mortality in gout
➡️Has not improved over time despite improved survival in the general population
➡️Worse among women
➡️Worse among Black individuals
#ACR23
👉🏽https://t.co/NDCIhKfCNL https://t.co/uKCswHKU0n
Dr Ai Lyn Tan @DrAiLynTan ( View Tweet )
2 years 3 months ago
