BAFF levels are high in patients lupus and allow for survival of autoreactive B cells. – Dr. M Kahlenberg on contributors to #SLE flares. #belimumab blocks BAFF but takes a long time to work, consider adding something faster active like steroids. @rheumnow #RNL2024 https://t.co/QGTcAgqjSN

T cells are important in SLE flares (but are not the only player) - Dr. M Kahlenberg @rheumnow #RNL2024 https://t.co/xFeYrKHnGi

Treatment of SLE. EULAR guidelines via @Kahlenberglab @RheumNow #RNL2024 https://t.co/a5lWfRLuh3

Triggers for SLE flare by @Kahlenberglab . Here in Ireland, it is so often UV light (oh its not warm enough for sunblock, its cloudy, I was only out for 20 minutes, etc). We must get our messaging better @RheumNow #RNL2024 https://t.co/0T1oJH8MqJ

Mimics of SLE flare by @Kahlenberglab . They are many, common, and crucial @RheumNow #RNL2024 https://t.co/P7b72T9GS6

Type 1 IFNs are a unique feature that impacts disease – Dr. M Kahlenberg noted innate immune cells & tissue are triggered by UV light, microorganisms, causing changes to the immune system: DC’s and B cells are more active, represses Tregs, drive skin disease. #RNL2024 @rheumnow https://t.co/fXnPIFN6VA

“Flares require a trigger!” – Dr. M Kahlenberg on #SLE flares #RNL2024 @rheumnow https://t.co/rqAnAOfJZP

Is it a lupus flare or a mimic? Fibromyalgia, stress, infection, poor sleep, hypothyroidism, vitamin deficiencies can contribute to pain and fatigue in a patient. – Dr. M Kahlenberg #RNL2024 @rheumnow https://t.co/pLuqyy8gHm

Lupus has many flavors. If we are better able to sort them, we might be more better at finding effective treatments. @rheumnow #RNL2024 @DrDavidKarp https://t.co/rklqnA8Ur6

"SLE affects women in the prime of their life, 25% of pts go to the ER, up to 50% will have lupus nephritis; it is a deadly and costly disease.” - @DrDavidKarp on why we would be focusing on identifying preclinical SLE and preventing the disease #RNL2024 @rheumnow https://t.co/SIZ5ZBwu94

Should we define preclinical SLE as stages rather than using confusing nomenclatures like UCTD, incomplete lupus, etc? - @DrDavidKarp @rheumnow #RNL2024 https://t.co/OjRjdBzJWE

When should you intervene? We talk about primary and secondary prevention... but what about primordial prevention that targets social determinants of health? - @drdavidkarp #RNL2024 @rheumnow https://t.co/UGAcNFLqZf