Toll-Like Receptor Drugs Effective in Cutaneous Lupus

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Enpatoran, an investigational oral drug that inhibits Toll-like receptors (TLR) 7 and 8, was superior to placebo in relieving lupus skin manifestations in a dose-finding phase II trial.

Lupus Mortality Risk in Young Women

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New research using death certificate data from 52,942 females, reveals that systemic lupus erythematosus (lupus) is a leading cause of years of potential life lost among young women in the United States, underscoring the disease’s significant and often underrecognized public health burden.

Chronic Low Back Pain Disappointments in a Randomized Trial

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Annals of Internal Medicine reports that patients with chronic low back pain (cLBP) may benefit from physical therapy (PT); but when that fails, other secondary measures (cognitive behavioral therapy (CBT) or mindfulness) may not be effective.

Vitamin D in Rheumatic Disease - is it Good Enough?

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Influential Rheumatoid Factors (5.8.2026)

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Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com

Gout Control Lowers Cardiovascular Events

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A large target emulation trial suggests that gout patients prescribed urate-lowering treatment who achieve a serum urate level lower than 6 mg/dL significantly lower their risk of cardiovascular events.

A Review of Hydroxychloroquine Ocular Toxicity

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While hydroxychloroquine (HCQ) is thought to be a very safe drug, its ocular risk profile is probably more serious than appreciated. A comprehensive review published in the Journal of Rheumatology discusses HCQ pharmacokinetics, mechanisms of retinal toxicity, risk stratification, and evidence-based screening protocols and how the drug can be used and monitored.

A Patient’s Plea for a New Paradigm in Autoimmune Disease

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A current article in Nature Reviews Rheumatology has a patient boldly asking why we rheumatologists aren't more like her oncologists?

Breaking the Rules: Dual-Advanced Combinations in Rheumatology

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For decades, the standard of care in rheumatology has been combination therapy - pairing methotrexate (MTX) with an advanced biologic or synthetic agent to achieve optimal outcomes. 

Metabolic Syndrome Predicts Cardiovascular Outcomes in Inflammatory Arthritis

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Chronic inflammatory arthritis (CIA) is associated with elevated cardiovascular risk. While metabolic syndrome (MetS) is prevalent, how much it contributes to adverse clinical outcomes is unclear.

More Comorbidity in Difficult to Treat RA

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A systematic review demonstrated that smoking, obesity, fibromyalgia, and depression are significantly associated with difficult-to-treat rheumatoid arthritis (D2T-RA).