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#acr19 @rheumnow
FDA notes w/Rheum Meds:
1. ⬇️apremilast dose in Apremilast to 30 mg/d for pt with severe CKD
2. Ok to use RTX in kids 2+ years old
3. Maintenance RTX 500 mg x2 the 500 mg q6mo x18 mo after induction Rx for GPA/MPA (kids use 250 mg/m2 dose then 250 mg/m2 q6 mo
k dao KDAO2011 ( View Tweet)
Abstr#1758: In pts with MSK symptoms and +antiCCP, those at high risk of developing RA had tenosynovitis, higher levels of IL-6 and ACPAs.
#ACR2019 @RheumNow #RA #rheumatoidarthritis
Maeve Gamble MaeveGamble ( View Tweet)
Some hand OA patients with an inflammatory phenotype have structural benefit from lower dose MTX (but no difference with pain or function, but no difference with adverse events). Why the disconnect? And what’s a rheumatologist to do?
Nice, France #ACR19 ABST1759 @RheumNow https://t.co/4SvWzps9DU
David Liew drdavidliew ( View Tweet)
The neutrophil nets take the win with nemaline rod myopathy which an be associated with congenital abnormality or HIV. Knowledge Bowl #ACRbest #ACR19 @RheumNow https://t.co/oIhWrcDUP5
Dr. Rachel Tate uptoTate ( View Tweet)
Great discussion on OA today at the Plenary session. #ACR19 @RheumNow
What would you try in your erosive OA patients who have failed conservative therapy (hand therapy, analgesics and NSAIDs)?
Maeve Gamble MaeveGamble ( View Tweet)
@RheumNow What about pred for hand OA? Well PNL 10 has an effect while you're taking it, with reduction of synovial thickening, and in this study was well tolerated. Stop taking it, and you're back to baseline.
Leiden #ACR19 ABST 1760 @RheumNow https://t.co/aw4UNHol7J
David Liew drdavidliew ( View Tweet)
Nice data in r-axSpA treated with ixekizumab showing improvements in fatigue, pain and sleep #ACR19 @RheumNow Abs 1510 https://t.co/raBP0Sv5bs
Philip Robinson philipcrobinson ( View Tweet)
Nice data from @Drbeckyg on patient self joint counts in #rheumatoid. This data supports patients ‘doing it for themselves’ to channel some Eurythmics.
#ACR19 @RheumNow Abs 1366 https://t.co/MgFpiDKO7W
Philip Robinson philipcrobinson ( View Tweet)
So proud of our Chan Mi Lee abstr#1717 comparing brain histopath in PACNS vs other causes of CNS vasculitis. Intramural inflammatory infiltrate more specific than perivascular @RulaHajjAliMD @LCalabreseDO @RheumNow #ACR19 @CleClinicMD #cleclinicrheum https://t.co/CpQH4Ezxzd
Cassandra Calabrese CCalabreseDO ( View Tweet)
Who will win? Elbow Knee, Joint Service Joint Service, or reigning champs Neutrophil Nets! Join us at Knowledge Bowl! @RheumNow #ACR19 https://t.co/IcUN4la4vP
Dr. Rachel Tate uptoTate ( View Tweet)
DAAs for Tx of hep C are changing the landscape of mixed cryo- incidence w/HCV steadily decreasing. Abstr#1723 @RheumNow @LCalabreseDO #cleclinicrheum #ACR19 https://t.co/QHDEjxPN7c
Cassandra Calabrese CCalabreseDO ( View Tweet)
Beautiful phase 2 data on a combined uricase and tolerigenic nanoparticle to reduce reactions and maintain irate lowering efficacy over 28 days. Roll on the HTH phase 3 with pegloticase #ACR19 @RheumNow #gout Abs 1235 https://t.co/NnMMgnbPbH
Philip Robinson philipcrobinson ( View Tweet)
Primary CNS vasculitis is hard to diagnose up front & bx data limited, but maybe reactive astrocytes (being CNS cells) might help differentiate versus mimics? We’ll take all the markers we can get
@ClevelandClinic @ChanmiLee @LCalabreseDO @RulaHajjAliMD #ACR19 ABST1717 @RheumNow https://t.co/gF7ayDO6vQ
David Liew drdavidliew ( View Tweet)
CZP improves PRO and most importantly sleep in non radio graphic SPAnpatients @RheumNow #ACR19 https://t.co/HfLor8jhSD
Dr. Arthur Lau ArthurRheum ( View Tweet)
#ACR19 @rheumnow Abstr#L09:
NORD-STAR trial: DMARD vs biologic 1st line Rx for early RA
All got MTX 25mg/wk x1 month then randomized to pred 20mg/taper to 5mg/d in 9 wks v. SSZ 2g bid v. HCQ 35 mg/wk + joint injx v. CZP v. TCZ v. ABT
High remiss in all group (best w/ABT)
k dao KDAO2011 ( View Tweet)
#ACR19 #rheumtwitter
@hausmannMD has a great e-poster this morning on #pedsrheum parental social media use ➡️ Over 700 parents were surveyed, can you guess how many were NOT using social media?
@rheumnow @RobShmerling @carrainc @TamarPedsRheum @DrTinyTree https://t.co/SIIpKd5HP8
Elizabeth Graef SituationRheum ( View Tweet)
Looks like giving methotrexate with pegloticase means most can complete their infusion course in uncontrolled #gout. Reduced reactions. MTX to the rescue! #ACR19 @RheumNow Abs 1236 https://t.co/UVE1ov2fno
Philip Robinson philipcrobinson ( View Tweet)
Checkpoint inhibitors in RA pts: it doesn’t matter why they flare (withdrawal of DMARD etc) - it’s manageable. Don’t deny RA patients potentially life-saving cancer immunotherapy!
@sandigursky #ACR19 ABST1339 @RheumNow following @cappelliMD’s call to arms https://t.co/oemBmibcvB
David Liew drdavidliew ( View Tweet)
#ACR19 @rheumnow ABS1481 Corrona PsA/SpA Registy: real-world use of Apremilast +biologics happens mostly in pts who received prior biologic therapy & pts not able to achieve MDA. otherwise similar characteristics vs those initiating biologic monotherapy and biologic + csDMARDs
Olga Petryna DrPetryna ( View Tweet)
NEW Guidelines for the Management of Takayasu Arteritis at #ACR19 (in one table!)
1. Everyone should get steroid sparing tx
2. Rec TNF > TCZ
3. Monitor pts closely!
4. Don't treat asymptomatic CRP
5. Med mgmt > surgical mgmt
Overall agreed - what about role of MTX?
@RheumNow https://t.co/vzpBHRDcKI
Mike Putman EBRheum ( View Tweet)