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Upadacitinib as monotherapy vs MTX. Wk48 results are consistent & good!
#ACR19 @rheumnow Abst0928 #ACRbest https://t.co/lmAMF3HqoI
Dr Irwin Lim _connectedcare ( View Tweet)
Upadacitinib monotherapy vs MTX. Safety data at wk48
#ACR19 @rheumnow Abst0928 https://t.co/P3La0rO9Nl
Dr Irwin Lim _connectedcare ( View Tweet)
Fenebrutinib wk12 results for both cohorts. Does not look better than ADA (secondary endpoint)
#ACR19 @rheumnow Abst0929 https://t.co/vIygXGn4vT
Dr Irwin Lim _connectedcare ( View Tweet)
One thing that Dan Clauw pointed out in his #fibromyalgia talk was that legalising cannabis in a state leads to dramatic reductions in opioid overdoses, in some cases showing reductions of >40% sustained for years.
#ACR19 @Rheumnow Ref -> https://t.co/buRPCqeR2A
Philip Robinson philipcrobinson ( View Tweet)
Great resource for rheumatic medications and breastfeeding. https://t.co/U88I6MmJDT #ACR19 @RheumNow #pregnancy
Maeve Gamble MaeveGamble ( View Tweet)
How to switch from MMF to AZA for pregnancy:
#ACR19 @rheumnow #pregnancy #lupus https://t.co/er4CvIkOBQ
Maeve Gamble MaeveGamble ( View Tweet)
A small New Zealand study (n=50) gave different doses of tart cherry concentrate and assessed its effect on serum urate over 28 days. No effect was found. We shouldn't be emphasising dietary changes in gout patients - no evidence of efficacy #ACR19 @RheumNow #gout https://t.co/OamMPMHw0C
Philip Robinson philipcrobinson ( View Tweet)
Abstr#548: Efficacy and safety of subcut CT-P13 (IFX biosimilar) 1 year after switching from IV CT-P13 in pts with RA. Non-inferiority of efficacy (decrease in baseline DAS28-CRP) at wk 22 achieved. Safety same. Another alt convenient way of administration? #ACR2019 @RheumNow
Maeve Gamble MaeveGamble ( View Tweet)
Basic truths of irAEs:
Symptoms do not equal irAEs, in diarrhoea/colitis as in arthralgias/arthritis. Substantial proportion excluded on investigation
Local site Rx where possible: because they often work, and systemic steroids still can’t be exonerated
#ACR19 @RheumNow https://t.co/TJHQkKcvX8
David Liew drdavidliew ( View Tweet)
Normal inflamm markers in PMR: 14% (62/454) of the Nijmegen PMR cohort fell in this group, and they had similar rates of follow-up, steroid dependence, even similar rates of GCA (albeit low). A subgroup of PMR we need to understand better!
Diane Marsman #ACR19 ABST0759 @RheumNow https://t.co/XS2bPrWKUf
David Liew drdavidliew ( View Tweet)
One of the hardest things about PMR is getting a reliable diagnosis - no biomarker and no histopath. Imaging has potential, and my colleague @drceowen has made a simple algorithm for reliable/replicable PET/CT dx 👍
@DrCMcMaster @jlyleung @Austin_Health #ACR19 ABST0755 @RheumNow https://t.co/JGswa6Wjju
David Liew drdavidliew ( View Tweet)
The C-AxSpand study, Certolizumab-treated nr-axSpA pts with shorter symptom duration (< 5 vs ≥ 5 years) showed greater improvements across signs and symptoms of disease and in quality of life. Kay J et al #ACR19 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
REDO trial: ultra low dose Rituximab for RA
500mg x 1 or 200mg x 1 compared against 1000mg
6mo non-inferiority
Could not formally show this but for many, ultra-low doses appeared effective
Should lead to longer term & tapering studies
#ACR19 @rheumnow Abst0931
Dr Irwin Lim _connectedcare ( View Tweet)
A Phase 2b study demonstrated the sustained efficacy of bimekizumab in pts with active AS to Week 48. Bimekizumab was generally well tolerated and no new or unexpected safety findings were identified #ACR19 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
You can treat all of the Hep C all of the time - but you won’t get rid of related cryoglobulinaemic vasculitis >10% of the time.
SVR with DAA in HCV does not equal vasculitis cured!
(PS you can even get it de novo after SVR)
n=1019 Egypt, France, Italy
#ACR19 ABST0948 @RheumNow https://t.co/Lp3ZVMwTgj
David Liew drdavidliew ( View Tweet)
Here is result to save you looking it up in this highly refractory group
#ACR19 @rheumnow Abst0930 https://t.co/gYv7CZcMvL https://t.co/ToIavKEn4z
Dr Irwin Lim _connectedcare ( View Tweet)
Abstr# L14: data shows that in PsA you’re able to withdrawal MTX from the combo of tofacitinib+MTX without any loss of efficacy. Great news, because pts really like to minimize their meds when possible. #ACR19 @rheumnow https://t.co/3cDoTc1gWB
Dr. Paul Sufka psufka ( View Tweet)
@RheumNow #ACR2019 ABS899 Tart cherry concentrate had NO effect on serum urate, urine urate excretion or the frequency of gout flares over 28-day study period (p=0.76). However, those receiving allopurinol had significantly greater increases in urinary anthocyanins (p< 001) https://t.co/JJm9RCILoH
Olga Petryna DrPetryna ( View Tweet)
The amazing @GrantSchulert helps us begin to understand sJIA-associated lung disease #ACR19 @rheumnow #Abstr #ACRBest https://t.co/NGnjEYDBnL
Jonathan Hausmann MD hausmannMD ( View Tweet)
How would vagus nerve stimulation help Rheumatoid Arthritis??
#ACR19 @rheumnow Abst0930 https://t.co/NupaKJkXCL
Dr Irwin Lim _connectedcare ( View Tweet)