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Spondyloarthritis Affects Pregnancy Outcomes

d Jack Cush, MD

A Danish registy has shown that the the prevalence of Spondyloarthritis (SpA) diagnosed prior to delivery has increased 5 fold in the last two decades and that SpA is associated with an increased risk of adverse pregnancy outcomes (APO).

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Apremilast Reduces Oral Ulcers in Behcet's Syndrome

d RheumNow

A multinational trial finds a statistically significant number of patients with Behçet's syndrome showed a greater reduction in the number of oral ulcers with apremilast compared with placebo.

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Metanalysis shows that although MTX may blunt some vaccine responses (eg Pneumococcal), the use of MTX, TNF inhibitors and other biologics should not deter vaccination as most vaccine responses are preserved despite therapy. https://t.co/KINrQMIQkt

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Dr. John Cush RheumNow ( View Tweet)

Study of two dietary patterns and the risk of SLE from the Nurses' Health Study (NHS, 1984–2014) and Nurses' Health Study II (NHSII, 1991–2015) shows no association between incident lupus and (healthier) prudent or (less healthy) Western diet. https://t.co/tvX2HqzWxF

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Dr. John Cush RheumNow ( View Tweet)

Spinal/SI MRI in the gen. population finds a high frequency of inflammatory and fatty MRI lesions suggestive of axSpA. MRI done in 793 volunteers < 45 yrs (49% males, 8.4% B27+). SI tJ Bone marrow edema in 17%, Vertebra BME 27% & fatty lesions in 81% https://t.co/XOzyWCyLyC

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Dr. John Cush RheumNow ( View Tweet)

Norways HUNT study shows NO fracture risk with PPI use in 15,017 women and 13,241 men aged 50–85 years. PPIs were not associated with an increased risk of fracture age-adjusted HR 0.82 (0.67–1.01) for women; 1.05 (0.72–1.52) for men. https://t.co/XIAdvxGTrz

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Dr. John Cush RheumNow ( View Tweet)

In the latest edition of @jrheum, our thoughts on why PMR should no longer be considered a syndrome of shoulder and pelvic girdle pain and stiffness, but rather a chronic inflammatory disease of musculotendinous structures. https://t.co/xtcZEqduhx @drdavidliew @earlyARA https://t.co/J2gqXi3PPw

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Claire Owen drceowen ( View Tweet)
If you needed more info that smoking isn’t great for #rheumatoid => Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients https://t.co/kg5ns6W65l

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Philip Robinson philipcrobinson ( View Tweet)

ESPOIR cohort with 172 early seronegative #RA patients finds that early csDMARD use (within 3 mos of Sx) was more likely to predict better outcomes that other prognostic risk (clinical lab or imaging) factors https://t.co/76J93mZ2NH

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Dr. John Cush RheumNow ( View Tweet)

Case-control study of 821 #RA cases & comorbidities between 2009 - 2018 shows some occur after RA- epilepsy (OR 2.13), sleep apnea (1.49), pulm fibrosis (4.63); others predispose to RA, IBD (3.82), T1DM (3.07), VTE (1.80) https://t.co/OV1FsAtMH6

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis shows that although MTX may blunt some vaccine responses (eg Pneumococcal), the use of MTX, TNF inhibitors and other biologics should not deter vaccination as most vaccine responses are preserved despite therapy. https://t.co/KINrQMIQkt

Links:

Dr. John Cush RheumNow ( View Tweet)

We are all going to get sick, the what and why is often unknown . This may be the hardest thing you'll ever do through. How you go through it will define you and deliver you..

Dr. John Cush RheumNow ( View Tweet)

(the Fonz says) Tenacity and gratitude are 2 words to live by. - Henry Winkler

Dr. John Cush RheumNow ( View Tweet)

Me and ⁦@AdamJBrownMD⁩ of Rheumination game in the studio to do ⁦@VindicoMedEd⁩ curbside consults on GCA! Sometimes the Dx is NOT so easy!!!Stay tuned to us and ⁦@HealioRheum⁩ ⁦@AWIRGROUP⁩ ⁦@RheumNow⁩ ⁦@VasculitisFound⁩ ⁦@ramos_casals⁩ https://t.co/nnMC9r5LsH

Leonard Calabrese LCalabreseDO ( View Tweet)

Looks like the latest ACR on Air podcast is up — episode 5 — recorded during #ACR19 with host @hausmannMD and @DrBhana and myself as guests. We discuss a couple of our favorite abstracts from the meeting. @ACRheum https://t.co/WHNiHuhenZ

Dr. Paul Sufka psufka ( View Tweet)
Very cool minilecture on how to read RCTs! https://t.co/jQUawxcEr1

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Dr. John Cush RheumNow ( View Tweet)

Gout Attacks Intensify with Heart Failure #cardiovascular https://t.co/LxCw8sCv5P https://t.co/ZukMrWuaeF

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Rheumatology Network RheumatologyNet ( View Tweet)
Our new review article is online detailing airway inflammation and RA pathogens is - Obstructive lung diseases and risk of rheumatoid arthritis https://t.co/Nmj9Uf6isl https://t.co/ByWVI0fYwa

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Jeff Sparks jeffsparks ( View Tweet)
Guselkumab, anti-IL23 in PsA Ph3 DISCOVER-1 trial in bio-naive or 30% prior TNFi = Effective at Wk 24 Safety same as with psoriasis trials. No Tb signal, No IBD signal. #ACR19 Abst0807 @_connectedcare https://t.co/d7hrn8VQO8

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Dr. John Cush RheumNow ( View Tweet)

Phase 2b Bimekizumab study results in PsA shows neutralizing IL 17F and IL 17A may be a new target for LDA/treatment. https://t.co/45Vahy36g7 #ACR19 @uptoTate abs#2881

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Dr. John Cush RheumNow ( View Tweet)

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