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The C-VIEW open-label study found a significant reduction in the AAU flare rate in axSpA pts with a history of recurrent AAU during the first 48 wks of Certolizumab. Pts also experienced significant improvement in axSpA disease activity #ACR19 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
@RheumNow #ACR19 ABS377 Stanford Univ retrosp stdy of pts w/ cardiac sarcoidosis supports use of TNFi in pts who failed cDMARs. Pts were able to reduce steroids dose w/no decline in LVEF in pts with preexisting CHF. larger, prospect studies needed
Olga Petryna DrPetryna ( View Tweet)
This is the device they used for the vagus nerve stimulation
#ACR19 @rheumnow Abst0930 https://t.co/XGKRjONTqf
Dr Irwin Lim _connectedcare ( View Tweet)
2 papers looking at TNFi on radiographic progression in Ankylosing Spondylitis. TNF inhibitor treatment slowed radiologic progression when compared to other therapies but covariables such as smoking and NSAIDs need to be considered #ACR19 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
Filgotinib in RA (FINCH3); Another👍🏼 result for JAKi
How will we choose which JAKi to use in an increasing crowded space? Any thoughts?
#ACR19 @rheumnow Abst0927
Dr Irwin Lim _connectedcare ( View Tweet)
@rheumnow #ACR2019 ABS857 Stdy of 21 SLE pts received allogenic mesench stem cells IV ⬇️ inflamm through upregulation of periph tolerogenic CD1c+ DC, esp in LN. UC-MSCs express FLT3L that binds to FLT3 on CD1c+DCs to promote proliferat&inhibit apoptosis of tolerogenic CD1c+DCs
Olga Petryna DrPetryna ( View Tweet)
Over two years, there can be progression of facet joint ankylosis with most progression occurring in the thoracic spine. Whole spine low dose CT is a research tool to study progression of facet joint in radiographic axSpA patients. van Gaalen #ACR19 @rheumnow
Dr. Antoni Chan synovialjoints ( View Tweet)
#acr19 @rheumnow abstr#0849 #ACRbest
French database: Risk for CA in RA with biologics compared to traditional sDMARDS: n= 83,659
1. No ⬆️ risk solid malig
2. HR lymphoma 1.35. p value not sig
3. NO diff CA b/t biologic monoRx vs comb biologic + DMARD
*nonmelanomatous skin CA
k dao KDAO2011 ( View Tweet)
The discrepancy in diagnosis between rheumatologists and radiologists reflects the increasing insecurity of including only BME of SIJ as the major criterium for diagnosing axSpA. Structural changes are also important. Baraliakos #ACR19 @RheumNow #axialspondyloarthritis
Dr. Antoni Chan synovialjoints ( View Tweet)
Listening to @AngusWorthing talk about what @ACRheum's advocacy efforts are doing for their members. #ACR19 @rheumnow https://t.co/aLYPuh0Clr
Dr. Paul Sufka psufka ( View Tweet)
Semi-axial combined with standard semi-coronal scans in MRI protocols for sacroiliitis improved recognition of non-specific BME, which is in the posterior lower ilium in association with SIJ features, and in the anterior upper sacrum #ACR19 @RheumNow #axialspondyloarthritis
Dr. Antoni Chan synovialjoints ( View Tweet)
There is a strong association between smoking and MRI-SIJ inflammation over time in axSpA patients with type of work and level of education level irrespective of other socio-economic factors, systemic inflammation and treatment. Nikiphorou #ACR19 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
Abstr#0848 @rheumnow #acr19 another study confirming that steroids dose correl to hospitalized infx: from Medicare database https://t.co/6SZqd0A8Xv
k dao KDAO2011 ( View Tweet)
Abstr#0846 @RheumNow #acr19 #acrbest
Eval of MACE and VTE of UPA based on phs 3 trials: 1. NO ⬆️risk MACE/VTE over 2 yrs compared to MTX, ADA
2. NO correl. w/lipid levels, dose of drug with MACE/VTE and UPA.
* despite the safety seen, UPA’s label still include VTE risk https://t.co/unOBvoW8Ub
k dao KDAO2011 ( View Tweet)
#ACR19 @ElenaNikiUK @RheumatologyUK vaccination: Calabrese suggests we should be more didactic in telling our patients to get the flu and shingles vaccines. I can see a clinic notice going up when I get home!
John Axford ProfAxford ( View Tweet)
Nintedanib brought modest benefit to IPF & SSc-ILD, but now ILD in other autoimmune dx as well?
Small but real diff in lung volumes, no diff in QOL or acute exac/deaths, diarrhea but largely not limiting in study. Works in absence of alt, but worth it?
#ACR19 ABST0374 @RheumNow https://t.co/1CDTgiQkMd
David Liew drdavidliew ( View Tweet)
After rituximab use, patients with ANCA-associated vasculitis had increased rates of hypogammaglobulinemia, as compared to patients with RA or CTD. Prednisone>10mg/day may in part account for this association. Dr. Stefanie Wade #ACR19 @rheumnow #Abstr #ACRBest https://t.co/CPWN2qSI9t
Jonathan Hausmann MD hausmannMD ( View Tweet)
Ileal but not colonic inflammatory gut lesions are linked to more fatty lesions on MRI-SIJ in newly diagnosed SpA patients. Baseline microscopic gut inflammation was not associated with erosions, sclerosis nor ankylosis. DeCraemer et al #ACR19 @RheumNow #axialspondyloarthritis
Dr. Antoni Chan synovialjoints ( View Tweet)
In early axSpA, inflammation in one SIJ quadrant leads to structural damage in the same quadrant. Rodrigues-Manaca #ACR19 @RheumNow #axialspondyloarthritis
Dr. Antoni Chan synovialjoints ( View Tweet)
“These drugs aren’t going anywhere because they are literally curing cancer.” - Dr. Susan Manzi on checkpoint inhibitors and autoimmune adverse events. Check out the poster hall to see all the emerging immune related AEs. #ACR19 @RheumNow
Maeve Gamble MaeveGamble ( View Tweet)