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PARE summary at #EULAR2024 - love the word cloud highlighting the posters @RheumNow
RA, SLE and JIA were the key RMDs that were focused on. By Silvia Aguleria https://t.co/WbSKwE6vXs
Links:
Bella Mehta bella_mehta ( View Tweet)
#EULAR2024 POS0375 Negative trial need to be reported too. Phase 2 RCT of S95011, an IL7-R antibody in moderate to severe systemic #Sjogren failed to meet primary endpoint (ESSDAI) or other secondary (ESSPRI, biomarkers). This inhibition unlikely to impact on SjD @RheumNow
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
EULAR PARE highlights
- Need close collaboration between patients and physicians.
-Child to adult transition need to be smooth to be successful (30% patients can be lost in transitions)
- We need patients to participate in Health Technology Assessment
@rheumnow #EULAR2024 https://t.co/50qFpRGXo2
Links:
Bella Mehta bella_mehta ( View Tweet)
Another proof (if needed) that controlling DA in RA is a very important preventive measure in RA!
179 pts
ILD newly developed 9.5%
progressed 12.3%
no change 74.9%
improved 4.5%
5.7% in the LDA group 28.0% non-LDA group (p=0.006)
@RheumNow #EULAR2024 POS0408 https://t.co/7DyXr5zdCM
Aurelie Najm AurelieRheumo ( View Tweet)
POS0061 (2024)
INTERCEPTION OF THE DEVELOPMENT OF RA BY 1-YEAR MTX IN ACPA-NEGATIVE ARTHRALGIA PATIENTS AT INCREASED RISK FOR RA: 4 YEAR RESULTS OF THE TREAT EARLIER TRIAL MTX reduced development of RA in high risk acpa neg pts https://t.co/XWnzuVMlbn @RheumNow #EULAR2024
Links:
Peter Nash drpnash ( View Tweet)
T2T strategy in RA during pregnancy improves time to procreate
Results PreCARA (T2T median DAS28CRP 2.33) vs. PARA median DAS28CRP 3.84)
median TTP 84d vs. 196d
TTP exceeded 12 months in 23% of PreCARA pts compared to 42% in the PARA pts.
@RheumNow #EULAR2024 POS0436 https://t.co/DfgEvvtCwR
Aurelie Najm AurelieRheumo ( View Tweet)
RISK OF NON-MELANOMA SKIN CANCER WITH TNFi AND OTHER bDMARDs IN PATIENTS WITH PSORIATIC ARTHRITIS: A SWEDISH AND DANISH COHORT STUDY- despite having minimal sun 25% increase NMSC TNFis vs other bDMARDs - skin checks ! @RheumNow #EULAR2024
Peter Nash drpnash ( View Tweet)
EULAR Abstract Archive
POS0894 (2024)
SAFETY OF UPADACITINIB ACROSS RHEUMATOID ARTHRITIS, PSORIATIC ARTHRITIS, AND AXIAL SPONDYLOARTHRITIS ENCOMPASSING 15,000 PATIENT-YEARS OF CLINICAL TRIAL DATA
Reassuring 15000 pt yrs f/u RA PsA AS https://t.co/XWnzuVMlbn @RheumNow #EULAR2024
Links:
Peter Nash drpnash ( View Tweet)
lets put this bed now @RheumNow #EULAR https://t.co/r0SVoOk47O
Peter Nash drpnash ( View Tweet)
EULAR Abstract Archive
OP0283 (2024)
LONG-TERM EFFICACY TOCILIZUMAB AFTER ULTRA-SHORT GC TO TREAT GCA: 3 Yr FOLLOW-UP OF THE GUSTO TRIAL
3 day GC pulse immediate 12 mths Toci 85% drug free remission at 4 yrs! https://t.co/XWnzuVMlbn @RheumNow #EULAR2024
Links:
Peter Nash drpnash ( View Tweet)
EULAR Abstract Archive
RISK OF PsA IN PATIENTS WITH PsO UNDERGOING bDMARDs GLOBAL POPULATION STUDY (TRINETX)
870,000 PsO pts without PsA treated with bDMARDS - Il12/23i and Il23i. 30-37% lower PsA developed than comparators https://t.co/XWnzuVMlbn @RheumNow #EULAR2024
Links:
Peter Nash drpnash ( View Tweet)
EULAR Abstract Archive
OP0031 (2024)
COMPARATIVE ANALYSIS OF TNF INHIBITORS & IL17 INHIBITORS IN PSORIATIC ARTHRITIS: CARDIOVASCULAR OUTCOMES signif absolute risk diff 3 % ischaemic heart disease 2 % heart failure TNFi vs IL17i https://t.co/fNIiMt4caL. @RheumNow #EULAR2024
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Peter Nash drpnash ( View Tweet)
Zoe @ZoeClarkOsteo from @NASSexercise @NASSchiefexec presenting her work from the Your SpAce self-management programme which covers topics on pain, fatigue, flares and much more #EULAR2024 @RheumNow https://t.co/q81JDHu7Oj
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Dr. Antoni Chan synovialjoints ( View Tweet)
Grappa « difficult to treat and complex to manage» PsA meeting - SLR, Patient & rheumo survey, working on definition eg - fail 1 csDMARD & 2 bDMARDs different MOA @RheumNow #EULAR2024
Peter Nash drpnash ( View Tweet)
CAR-T - autologous vs allogenic , need for full induction , safety of retreatment, CAR-T lymphoma/leukaemia, cost, ideal candidate ? @RheumNow #EULAR2024
Peter Nash drpnash ( View Tweet)
opposing point of view to previous post @RheumNow #EULAR2024 https://t.co/T72r8kXF1j
Peter Nash drpnash ( View Tweet)
#EULAR2024 POS1325 Childhood onset #lupus is often more severe with high mortality rate. Similar to findings in adults, 2 cSLE patients with refractory disease including failure to CyC, RTX & PLEX responded to CD19 CAR T cells with similar short term safety profile @RheumNow https://t.co/YD2arjxcso
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
lanalumab (anti-baff) LTE 1/3 to 1/2 LLDAS/DORIS remission at 52 wks, reduction autoabs etc - looking very promising @RheumNow #EULAR2024
Peter Nash drpnash ( View Tweet)
Frank Buttgereit discusses potential reason for ceiling effect in RA and questions why we don’t use more combination therapy in RA (including low dose of of GC), using the example of Hypertension guidelines
Is long term low dose GC in RA really a desirable option?
@RheumNow… https://t.co/Nc7lldN7Nd https://t.co/63K96uuhKG
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Aurelie Najm AurelieRheumo ( View Tweet)
Tips to help in self-management. Procrastination is a huge barrier to self-management. Delegate and prioritise #EULAR2024 Andrea Marques @RheumNow https://t.co/SbQgOMwqL0
Links:
Dr. Antoni Chan synovialjoints ( View Tweet)