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Myositis Patients at High Risk of Opportunistic Infections

d RheumNow

Among patients with systemic rheumatic diseases, the highest incidence of opportunistic infections was seen in those with polymyositis/dermatomyositis (PM/DM), Taiwanese researchers found.

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One-Third of Psoriatic Arthritis Patients Will Need Joint Surgery

d Jack Cush, MD

Dannish study has shown that one-third of psoriatic arthritis (PsA) will have joint surgery that that PsA patients have twice the rate of joint surgery when compared with the general population.

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Warfarin Superior to Xarelto in Antiphospholipid Syndrome

d Jack Cush, MD

A 3 year, multicenter, European, study shows that rivaroxaban was inferior to warfarin in preventing thrombosis in patients with antiphospholipid syndrome (APS) according to the Annals of Internal Medicine. Thus despite the inconvenience of warfarin, it remains the best option for patients with APS.

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Stress and the Risk of Incident Inflammatory Arthritis

d Jack Cush, MD

A prospective analysis of newly diagnosed, inflammatory arthritis (IA) patients suggests that perceived distress (stress) increases the odds of incident IA.

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Hydroxychloroquine Blood Levels May Predict Future Retinopathy

d Jack Cush, MD

A study of 527 patients receiving daily hydroxychloroquine (HCQ) concluded that hydroxychloroquine blood levels may predict future HCQ retinopathy.

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ACR 2018 - Day 1 Report

d RheumNow,  , EyeMah , , DenMah

Highlights from Tuesday and Wednesday (days 3 and 4) from the ACR annual meeting include: the important and impactful abstracts covered by the Rheumatology Roundup session; upadacitinib clinical trials; and the baricitinib CV and VTE safety analysis.

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Juvenile Arthritis at Risk for Coronary Artery Disease

d Jack Cush, MD

Arthritis Care & Research reports that juvenile arthritis (JA) patients may have a higher risk if coronary artery disease (CAD) in adulthood. 

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SURVEY: When choosing drug therapy for GCA, what mechanism are you targeting? IL-1, IL-6, TNF, inflammation? Survey for RHEUMATOLOGISTS - please vote here>> https://t.co/qhpOxYz3Qt

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Dr. John Cush RheumNow ( View Tweet)

Statin induced myopathy is occurs in less than 1%; rhabdomyolysis and necrotizing myositis are very rare. HMGCR Abs against (HMG-CoA) reductase are seen 2- 3 of every 100,000 patients treated with statins. https://t.co/44DGaHEGjo

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Survey for Rheumatologists – In Giant Cell Arteritis - When do you add a steroid sparing agent? https://t.co/qhpOxYhsYV

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Dr. John Cush RheumNow ( View Tweet)

RISE registry: among 7,274 RA pts w/ serial data [RAPID3 (78.9%) & CDAI (34.2%)]. Amongst those w/ moderate/high disease activity, frequency of DMARD change was low (36%-55%). Less likely to change was elderly, Combo DMARDs or biologics. https://t.co/IppHCxJWk1

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Dr. John Cush RheumNow ( View Tweet)

Followup of 783 tofacitinib‐treated psoriatic arthritis patients finds increases in LDL and HDL 9% to 14% after 3 and 6 months of therapy with a low risk of HTN or MACE events https://t.co/fh6UbmF3lr

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Dr. John Cush RheumNow ( View Tweet)

RheumNow LIVE VOTE Survey: When treating a patient for GCA, when might you add a steroid-sparing agent?? If youre a RHEUMATOLOGIST - please vote in our quick 4Q survey https://t.co/qhpOxYhsYV

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Dr. John Cush RheumNow ( View Tweet)

Comparison of 69 SLE pts w/ C/S+ infection vs 69 SLE without infx shows that serum procalitonin did not distinguish those w/ infection, BUT C-reactive protein did successfully identify those SLE patients with infection https://t.co/HMHqfaP0Cg

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Dr. John Cush RheumNow ( View Tweet)

Taiwanese Claims data study shows the risk of opportunistic infection in ~77K autoimmune pts shows OI highes in PM/DM cases (61.3/1000PY), followed by SLE (43.1/1000PY), SSc (31.6), RA (25), and pSS (24.1). OI risk highest during 1st year https://t.co/YKP7ZF7FIx

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Dr. John Cush RheumNow ( View Tweet)

Study of 179 RA pts achieving remission on TCZ- SC 162 mg qwk randomized to continue qWk or space out to q2Wk -- Weekly Actemra better maintained remission (90% versus 73%; P = 0.004), but then again 73% did well w/ spacing to every other week. https://t.co/ywvsDMxS6M

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Dr. John Cush RheumNow ( View Tweet)

Logical + Data-driven = Annoying. (If you have high standards does that make you arrogant?)

Dr. John Cush RheumNow ( View Tweet)

RheumNow Podcast is up! When you're hot you're hot! Watch it on youtube>> https://t.co/GlqMzjUnhE or listen to the podcast on iTues, Apple podcast or on Stitcher or SoundCloud>> https://t.co/a1zE7VXtog

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Dr. John Cush RheumNow ( View Tweet)

China retrospective study of 727 SoA abd 857 RA pts shows risk of H. Zoster same between SpA & RA (aHZ=0.97), but was significantly higher with MTX (adj HR 3.47) and infliximab (adj HR 10.67) https://t.co/gpictKPpIT

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Podcast is up! When youre hot youre hot! Watch it on youtube>> https://t.co/GlqMzjUnhE or listen to the podcast in your car on iTues, Apple podcast or on Stitcher or SoundCloud>> https://t.co/a1zE7VXtog

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Dr. John Cush RheumNow ( View Tweet)

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