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ICYMI: Protective Benefit of Colchicine in COVID-19 Infection

d Jack Cush, MD

Colchicine has been advocated as a potential anti-inflammatory intervention in patients with the coronavirus 2 infection and clinical trials have been developed to assess its effect in early COVID-2 infection.  JAMA has published a randomized clinical trial showing that low dose colchicine had less clinical deterioration without significant changes in biomarkers, such as high-sensitivity cardiac troponin and C-reactive protein.

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ICYMI: Preventing COVID - Masks, Meters and Eyewear

d Jack Cush, MD

A Lancet systematic review and meta-analysis provides the basis for physical distancing and the value of making as measures to prevent infection with coronavirus 2 (SARS-CoV-2) or COVID-19.

The analysis included 172 observational studies, no randomised controlled trials and 44 relevant comparative studies involving 25 697 patients. 

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ICYMI: COVID-19 and Thrombotic Complications

d Jack Cush, MD

Severe and fatal outcomes with coronavirus infection are often the result of the downstream damage that follows the viral infection. Rising high on the list of complications are the hematologic and vascular complications seen in severely affected patients, so much so that many centers are routinely anticoagulating hospitalized (but not ambulatory) COVID patients.

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ICYMI: The Nine Lives of Hydroxychloroquine (Updated)

d Martin J. Bergman, MD

Hydroxychloroquine is one of many medications frequently used in rheumatology practice. Its remarkable versatility is attested by its routine use in lupus, in patients with an autoimmune coagulopathy, in patients with rheumatoid arthritis, as well as in those with a low-level inflammatory arthropathy.

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Reminders on Masking: 1. Everyone should wear masks; most who are infected dont know they are infx (asymptomatic); 2. Risk of transmission is directly correlated with the duration and intensity of contact - especially in closed quarters; less so if outside https://t.co/9nw43kPrhN

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Dr. John Cush RheumNow ( View Tweet)

10 FALSE reasons for not wearing a mask - https://t.co/zOViN8n4Yw Please wear a mask out of concern and care for others !!

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Dr. John Cush RheumNow ( View Tweet)

Check my updated virtual video joint exam for rheumatologists - Video here> https://t.co/ZXEUKcw5mb or listen to the podcast>> https://t.co/XSHWuwxJ9L https://t.co/lBtG0lvAZM

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Dr. John Cush RheumNow ( View Tweet)
Open label, uncontrolled study shows that background use of azathioprine (2mg/kg) in Pegloticase treated refractory… https://t.co/uXQR8JE1he

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Dr. John Cush RheumNow ( View Tweet)

Skin is often involved w/ ANCA+ vasculitis - 1184 AAV pt study shows skin involvement in 34% GPA; 28% MPA & 47% EGPA. Common are petechiae/purpura pruritus, urticaria, and maculopapular rash. AAV w/ skin Sxs have more systemic dz (GN, alveolar hemorrhage) https://t.co/egPdW2IEnu

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Dr. John Cush RheumNow ( View Tweet)

Great NY Times article on 30+ years of an adversarial friendship between Dr. Tony Fauci and AIDS activist Larry Kramer (who recently passed away). Keen that adversaries can still be on the same side, pushing for change differently https://t.co/lnfk6fXfF2

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Dr. John Cush RheumNow ( View Tweet)

H2H UPA vs ABA RCT; UPA is clinically superior to ABA in DAS-CRP remission, ACR50, ACR70 at wk 12/24 (NOT diff in P… https://t.co/7lwVCSYjPu

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Dr. John Cush RheumNow ( View Tweet)

Avacopan is as effective as steroids in ANCA Assoc Vasculitis – 330 pt RCT AAV Rx w/ RTX or CTX but randomized to p… https://t.co/mxm5NAjZtL

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Dr. John Cush RheumNow ( View Tweet)

#EULAR2020 #op0201 nationwide cohort study: higher incidence of dementia in SLE (3.9/1000pys) vs non-SLE ( 2.73/1000pys). HR 1.43. SLE risk of Alzheimer’s 1.4x &risk of vascular dementia 1.6x Higher than non-SLE cohort. Further studies to identify mechanism needed @RheumNow https://t.co/IL6KPvP320

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Dr. John Cush RheumNow ( View Tweet)

AHRQ estimates that 40-80% of information a patient is told during an office visit is forgotten immediately, and that almost half of the information a patient does retain is actually incorrect https://t.co/XeGx2YXsOQ

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Dr. John Cush RheumNow ( View Tweet)

23 yoF with 1 mos digital ulcers, hair loss, sicca Sxs, dysphagia; No sclerodactyly but finger tips cyanotic w/ distal pitting scars, ischemic ulcers, periungual erythema & dilated nailfold capillaries (no hemorrhages). +tests for ANA, Ro52, Ro60 and Scl-70 Abs. How to treat?

Dr. John Cush RheumNow ( View Tweet)

African-Americans with Ank Spondylitis have worse disease compared to whites. Study of 10,990 AS patients shows AA to have high frequency of anterior uveitis, hypertension, diabetes, depression, and heart disease and higher ESR and CRP levels. https://t.co/YyLqlM85sD

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Dr. John Cush RheumNow ( View Tweet)

Rheumatology Round-Up from #EULAR2020 w/ Drs. Kavanaugh & Cush. Watch it on RheumNow https://t.co/5v9BTuLrPX or listen to the podcast on iTunes https://t.co/FHJv01AAbC or on Android Sound Cloud https://t.co/nb7iXdRMMb

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Dr. John Cush RheumNow ( View Tweet)

#EULAR2020 #op0106 Cosentyx 150mg demonstrates clinical improvement in NrAxSpA Sx in Ph3 PREVENT @52wk. Significant improvement in ASAS40, BASDAI50& ASdAS-CRP ID. MRI BME score significantly decreased (-1.68&-1.03 (no LD) vs -0.39 PBO) @RheumNow https://t.co/5sDAZRhmzW https://t.co/cDjduG38lr

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Dr. John Cush RheumNow ( View Tweet)
CDC guidelines for Rx of Latent Tuberculosis; Preferred: A) 3 months of once-weekly INH plus rifapentine (3HP); B) 4 months of daily rifampin (4R); C) 3 months of daily INH plus rifampin (3HR) - Shorter, safer, effective with higher completion rates. https://t.co/a2iZczFTP2

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Dr. John Cush RheumNow ( View Tweet)

A msg from my nurse friend: “A blood clot from my pt yesterday. Covid lungs. I helped changed his code to DNR, talked to his son/ex wife/brother&sister to say goodbye. He asked if I would pray w/him. I prayed. He cried. Then I walked out & lost it. The public doesn’t get it.” https://t.co/AOdXshjTWL
k dao KDAO2011 ( View Tweet)
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