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Osteoporosis Tx: Good for Bones, but Not for Cutting Death Risk

d RheumNow

Osteoporosis treatments were not linked with reduced overall mortality, according to a meta-analysis of placebo-controlled trial data.

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Good Pregnancy Outcomes for DMARD Exposed JIA Patients

d Jack Cush, MD

A study of pregnancy outcomes in 98 women with juvenile idiopathic arthritis (JIA) who were exposed to DMARDs shows no increased risk of major adverse pregnancy outcomes.

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Autoantibodies Don't Disappear With Remission in RA

d RheumNow

Immunologic remission in rheumatoid arthritis, defined as the disappearance of anti-citrullinated protein antibodies and rheumatoid factor, was seen infrequently among patients achieving sustained clinical remission and did not correlate with the disappearance of symptoms, a long-term Dutch study found.

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Skyrizi Outduels Humira in Psoriasis

d Jack Cush, MD

A head-to-head trial has shown that risankizumab was significantly superior to adalimumab in providing skin clearance (PASI90) in patients with moderate-to-severe plaque psoriasis, with no difference in safety signals between the two agents.

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RCT of 139 knee OA pts given either curcumin 500-mg tid or diclofenac 50-mg bid. At days 14 and 28 both had similar improvement in pain and KOOS score; but curcumin had better tolerance, less GI sxs and H2 blocker use. https://t.co/tcsDQWQOMg

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Retrospective review of US-guided Synovial Biopsies performed (clinical practice n=52, research n=12) - syn tissue obtained in 88%. Utility/impact was good (37% Dx impact, >95% PPV or NPV for infection & research 92% success. https://t.co/A7vzIHnKH1

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Study of 1272 RA pts, 69.5% were seropositive. Seropositive RA patients had two-fold increased risk for abnormalities on PFTs (ORs ranging from 2.48 RLD, 3.12 COPD & 2.30 DLCO abnl; associations were stronger for RF+ than for CCP+. https://t.co/RQ5GgoGqwA

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Thurs 8AM - start of the 2nd NIH Symposium on Autoinflammatory and immune-dysregulatory Diseases - World experts on IL-1 mediated autoinflammatory diseases, autoinflammatory Type-I interferonopathies, MAS/HLH, LIVE STREAMING AT 8AM EST https://t.co/XJ4EOIXyYm

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Retrospective review of temporal artery biopsies from Johns Hopkins Wilmer Eye institute from 2007-17 shows the adjusted incidence rate of Bx+ GCA was 3.1 (1.0-5.2) in blacks and 3.6 ( 2.5-4.7) per 100 000 white patients; higher in women (1.9x vs Men) https://t.co/MeO9cBqovg

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CMAJ reports on a case controlled study of >3000 pts shows GERD to be a a risk factor for TMJ disorders (OR 2.74; 1.88 to 3.98) with such patients having a higher rates of somatization, anxiety and sleep disorders. https://t.co/jrTPCOVouI

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Dr. John Cush RheumNow ( View Tweet)

Analysis of 128 Pediatric Rheum pts (JIA, FMF, etc) analzyed for reactions to 8 different biologics during 32,494 infusions/injections - the frequency of anaphylaxis (from TCZ or RTX) was 3.9% in children. https://t.co/GzvcR0R7Bv

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Dr. John Cush RheumNow ( View Tweet)

Telemedicine study of 122 #RA patients in the Alaska Tribal Health System shows that video telemedicine was more in pts with higher disease activity, positive views of telemedicine, and whose physicians used telemedicine more often. https://t.co/Y95ihyfSs8

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Dr. John Cush RheumNow ( View Tweet)

Dermatomyositis with anti-MDA5 Ab is at high risk of severe rapid interstitial lung disease. Study of 31 MDA-5+ pts shows those with pneumomediastinum at higher risk for mortality, liver dysfunction, worse respiratory dz and Chest CT scores https://t.co/puFPLG2kOx

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87 #Gout patients treated with ULT and followed with serial Xrays and DECT scanning shows that lowering uric acid in a T2T strategy did not change xray over 2 years, but did show significantly less urate erosions by DECT. https://t.co/XRwkyyI4lr

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Dr. John Cush RheumNow ( View Tweet)

Are you an Expert in Still's disease, Periodic Fevers, FMF or Autoinflammatory Dz? Please let me know ASAP - I want to add you to the list! https://t.co/UwKkco8q1N

Dr. John Cush RheumNow ( View Tweet)
Studies analyzing the microbiome (by 16S ribosomal RNA bacterial gene testing) of 107 healthy subjects, and 696 twin pairs from the TwinsUK cohort shows that the microbiome is significantly and uniquely influenced by HLA- B27 and HLA–DRB1. https://t.co/vOJAjZD6bG

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Dr. John Cush RheumNow ( View Tweet)

Abbvie has announced that the annual price for its new FDA approved JAK1 inhibitor, Rinvoq, will be $59,000. https://t.co/22LIetdTUh

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Dr. John Cush RheumNow ( View Tweet)

Part 4 - War on RA - Desperado, the Eagles, Glenn Fry inspire Desperado to stop riding fences - on RheumNow; heres the video>> https://t.co/dgShcQpWHP or listen to the podcast on iTunes or here>> https://t.co/zEL85WKnyT

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Dr. John Cush RheumNow ( View Tweet)

FDA approves Abbvies new JAK1 inhibitor - upadacitinib (named Rinvoq); Package insert - indicated for use in mod. to severely active RA not resp to MTX (do not combine w/ other JAKS, biologics). 15 mg qd. Warning for VTE, DVT. https://t.co/9KODynuWKC https://t.co/zRpeiaiTNS

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Podcast is up! Antibiotics causing RA? Watch here> https://t.co/tm5vpCtXpa or listen on iTunes or SoundCloud>> https://t.co/CbXpk4OUaS

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Dr. John Cush RheumNow ( View Tweet)

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