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Targeting GM-CSF Works in Rheumatoid Arthritis

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d RheumNow

Apr 26, 2019

Namilumab, a monoclonal antibody that targets the granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand, showed promise as a treatment for rheumatoid arthritis (RA) in a phase II study.

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RheumNow Podcast – Take it Back Jack! (4.26.19)

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d Jack Cush, MD

Apr 26, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com

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Naproxen has no Effect on Alzheimer's

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d Jack Cush, MD

Apr 25, 2019

A randomized controlled trial shows that chronic low-dose naproxen does not reduce progression of presymptomatic Alzheimer disease (AD).

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More Studies Needed to Optimize the Use of Osteoporosis Drugs

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d Jack Cush, MD

Apr 25, 2019

The Annals of Internal Medicine reports a metanalysis done to examine the optimal length of long-term osteoporosis drug treatment (ODT) and whether harms are associated with long-term ODT and while the ODT benefits are clear, the risk of rare harms and need for drug holidays is less certain.&nbsp

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Creaky Joints - a great website for patients with arthritis is now available in Spanish! https://t.co/xvApzvY2Hh

Links:

https://buff.ly/2UZk9M5

Dr. John Cush RheumNow ( View Tweet)

Apr 29, 2019

FDA has approved Samsung-Bioepsis biosimilar version of etanercept - Eticovo (etanercept-ykro), approved in other countries under names Benepali and Brenzys. Approval based on 596 RA pt trial w/ 52 wk ACR20 of 80.8% and 81.5% (Enbrel arm) https://t.co/r3q9dQ0Bdb

Links:

https://buff.ly/2UJ6XWF

Dr. John Cush RheumNow ( View Tweet)

Apr 29, 2019

Benlysta is approved for use in pediatric SLE based on the 80 pt PLUTO trial; 1 yr of PBO vs 10 mg/kg belimumab plus standard therapy. Results presented at ACR2018 shows BEL in pediatric SLE to be safe and effective (SRI4 resp 52.8% vs 43.6%). https://t.co/cjqPaWu92O.

Links:

https://buff.ly/2L9cR3H

Dr. John Cush RheumNow ( View Tweet)

Apr 29, 2019

RheumNow Podcast is up ! Cardiac risk in RA sibs; NSAIDS & Fx nonunion; Treating Calcinosis Cutis; whats a Skyrizi? Watch the video https://t.co/NNsUFcGkWT or listen to the podcast on iTUNES or SoundCloud >> htps//soundcloud/rheumnow/rheumnow-podcast-take-it-back-jack-42619

Links:

https://buff.ly/2IKQm3e

Dr. John Cush RheumNow ( View Tweet)

Apr 26, 2019

Animal data suggests targeting of neutrophils in APS may mitigate thrombotic disease. Adenosine recept agonists suppresses aPL Ab-mediated NETosis & reduces IVC thrombosis. Same shown for dipyridamole (incr. adenosine & cAMP breakdown). https://t.co/BHACehh0lb

Links:

https://buff.ly/2Uv7onr

Dr. John Cush RheumNow ( View Tweet)

Apr 26, 2019

Comparing nearly 230,000 Taiwanese with and without gout shows gout pts have more psoriasis (1.6% vs 1.1%; adjusted OR 1.30; 1.20-1.42) and psoriatic arthritis (0.3% v 0.1%; aOR 2.50; 1.95-3.22). https://t.co/c1ZVy5E6vk

Links:

https://buff.ly/2UUKkDn

Dr. John Cush RheumNow ( View Tweet)

Apr 26, 2019

Vote on the NEJM Question of the week - Which one of the following vaccination regimens is recommended for a 62-year-old woman with systemic lupus erythematosus who is being treated with prednisone 5 mg daily? Go here to vote https://t.co/27an4cVdqv

Links:

https://buff.ly/2xHcN1b

Dr. John Cush RheumNow ( View Tweet)

Apr 26, 2019

Biologic and Glucocorticoid Use after Methotrexate Initiation in Patients with Rheumatoid Arthritis https://t.co/kuX8X6l99V https://t.co/p4kr42piYy

Links:

http://ow.ly/x6ni30otbu5

The Journal of Rheumatology jrheum ( View Tweet)

Apr 25, 2019

Another Step beyond the DEAs Take Back program that ocurrs twice a year (April and October), including Saturday April 27th - see my earlier tweet on this today https://t.co/WPt6VIboMW

Links:

FDA Drug Information on Twitter: "As part of the #RemoveOpioidRisk campaig…

Dr. John Cush RheumNow ( View Tweet)

Apr 25, 2019

Results from Nationwide Inpatient Sample Database (2003–11) finds 31,439 obstetric hosp. in RA women who had a higher maternal age (30.5 yrs) & significantly more HTN, premature membr. rupture, antepartum hemorrhage, preterm delivery, IUGR & C sections https://t.co/pz5uQH5rrx

Links:

https://buff.ly/2IUlb4x

Dr. John Cush RheumNow ( View Tweet)

Apr 25, 2019

Swedish population study compared 8109 RA pts and 11562 full siblings to the general population, finding the risk of acute coronary syndrome to be increased in RA (HR 1.46; 1.28 -1.67) and RA Sibs (HR 1.22; 1.09 - 1.38) w/ risks confined to seropositives https://t.co/oYUP3jgY60

Links:

https://buff.ly/2IWyHEL

Dr. John Cush RheumNow ( View Tweet)

Apr 25, 2019

This Saturday is National Prescription Drug Take-Back Day where you can dispose of old, unused, unwanted (Potentially harmful) prescription medicines. These are run by your local police or DPS. Use this link to find out where in your town https://t.co/eae3l6OtqC

Links:

https://bit.ly/2y0XEGk

Dr. John Cush RheumNow ( View Tweet)

Apr 25, 2019

Danish study of 92 355 adults compared Fx rates between new users of denosumab (DEN) or alendronate - finds no advantage for DEN for hip Fx (aHR 1.08; 0.92-1.28) or any Fx (aHR 0.92; 0.83-1.02). Data doesnt support preference for DEN in high risk pts. https://t.co/dpyRF9VxH6

Links:

https://buff.ly/2Vl8UNp

Dr. John Cush RheumNow ( View Tweet)

Apr 25, 2019

3002 UK study shows that statin (atorvastatin) use in RA is safe and effective - resulting in significant reduction in Cardiac/MACE events (HR 0.60), LDL (HR 0.77) and CRP and confers a risk reduction similar to that seen in other populations https://t.co/Zl2KaK12P5

Links:

https://buff.ly/2UVmtn2

Dr. John Cush RheumNow ( View Tweet)

Apr 24, 2019

Metanalysis shows NSAIDS increase rates of delayed union or nonunion (OR 2.07; 1.19 to 3.61) in adults with fracture, osteotomy, fusion surgery; but not in pediatrics (OR 0.58) or with low dose/short duration NSAID exposure (OR 1.68). https://t.co/0tM8OFLhzt

Links:

https://buff.ly/2vig9Hb

Dr. John Cush RheumNow ( View Tweet)

Apr 24, 2019

UK NHS study shows RA patients have a 1 in 5 lifetime risk of knee and hip replacement. 13 961 RA pts fins a 22% (TKR) and 17% (THR) risk following a RA Dx (for an avg 64 yr F, nonsmoker, BMI27). Risk is even higher in younger patients. https://t.co/asOVrRUZLx

Links:

https://buff.ly/2KUw35f

Dr. John Cush RheumNow ( View Tweet)

Apr 24, 2019

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