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Chronic Kidney Disease Augments Gout Risks

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d Jack Cush, MD

Apr 09, 2019

A population based cohort analysis shows that patients with incident gout and chronic kidney disease (CKD) have far worse outcomes than those without CKD.

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ACR Position Statements on Drug Pricing and Step Therapy

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d Jack Cush, MD

Apr 08, 2019

The American College of Rheumatology Committee on Rheumatologic Care has released new drug pricing and step therapy position statements that they hope legislators will consider as they continue to explore policy and regulatory options to make drugs more affordable and accessible.

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Increasing Prevalence and Consequences of Interstitial Lung Disease in RA

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d Jack Cush, MD

Apr 08, 2019

Interstitial lung disease (ILD) has been a hot topic in numerous journals recently with reports of increasing incidence and links to disease activity.

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A downward trend in Rheumatology fellowship positions reversed after 2013 and since (2014-17) there has been a 44% increase in fellowship positions (230-332), more than other subspecialties. More applicants per position, more US grads, higher salaries. https://t.co/STbmG4QnSA

Links:

https://buff.ly/2OWs2eZ

Dr. John Cush RheumNow ( View Tweet)

Apr 10, 2019

Long term tofacitinib in RA shows lymphocyte #s dropped ~24% by 48 mos. Monitor ALC at baseline & q3 mos; ALC <500 seen in 1.2% of 2983 pts and was assoc w/ higher risk of SIE & Zoster. ALC <500 more likely with low ALC, age, higher dose Tofa & MTX https://t.co/5CHMmoGWJw

Links:

https://buff.ly/2OYjpjP

Dr. John Cush RheumNow ( View Tweet)

Apr 10, 2019

US Veterans Study examined 17,415 patients starting MTX - only 20.6% started a biologic w/in 2-yrs. Biologic use was significantly lower in elderly [aHR 0.20 ≥ 80 vs < 50], pts w/ comorbidities [aHR 0.79], CHF [0.68], cancer [0.78] & nonwhites [0.79] https://t.co/3LcPVQAgcp

Links:

https://buff.ly/2U7YPPi

Dr. John Cush RheumNow ( View Tweet)

Apr 09, 2019

151 pts w/ myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) were treated with either rituximab or PBO showing no effect of RTX!! Really? someone, somewhere believes ME/CFS or FM is an immunologic dz? Do NOT use biologics, DMARDS in such pts. https://t.co/1xXG94QEnP

Links:

https://buff.ly/2YHTl13

Dr. John Cush RheumNow ( View Tweet)

Apr 09, 2019

Data from the Osteoarthritis Initiative (n 4369) shows that fluctuating or persistent Knee pain over 1 yr had an increased risk of cartilage volume loss and structural progression over 4 years (OR 1.62, 95% CI 1.04–2.54) https://t.co/Inf4WsQ4Lz

Links:

https://buff.ly/2YWtthT

Dr. John Cush RheumNow ( View Tweet)

Apr 09, 2019

17.6 million adult Americans, 1 of 12, have an alcohol-use disorder, according to the National Council on Alcoholism and Drug Dependence. https://t.co/duojLFsNjD

Links:

https://buff.ly/2Z0DfQ4

Dr. John Cush RheumNow ( View Tweet)

Apr 09, 2019

Analysis of CareRA, early RA 330 pt trial shows long term outcomes linked to initial response type rather than regimen. Best PROMs in the 42% with early persistent response. 9% were primary NR, 28% secondary NR, 21% delayed responders. https://t.co/ZDqYD3krtb

Links:

https://buff.ly/2Kh5DKK

Dr. John Cush RheumNow ( View Tweet)

Apr 08, 2019

Long term safety study of 4481 tofacitinib pts w/ 9.5yrs exposure (16,291PYs). 52% discontinued Rx (4% insufficient response; 24% adverse events). AE incidence rates were 3.4/100PY for H zoster, 2.4/100Py SIE, 0.8 cancer, 0.4 MACE, 0.3 Mortality. https://t.co/Qv5keuKXr3

Links:

https://buff.ly/2P3hStb

Dr. John Cush RheumNow ( View Tweet)

Apr 08, 2019

41 study Metanalysis on H zoster drug risk in psoriasis and PsA - finds an increased risk w/ steroids, tofacitinib, biologic +DMARD Combination Rx. But no risk with monotherapy. Insufficient evidence for IL-12/23, -7, -23 inhibitors or apremilast https://t.co/KRrTqIw7Ko

Links:

https://buff.ly/2IoDnmV

Dr. John Cush RheumNow ( View Tweet)

Apr 08, 2019

NSAIDS can reduce fertility in women - from Dr Sammaritano. #RNL2019

Madelaine Feldman MattieRheumMD ( View Tweet)

Apr 04, 2019

#RNL2019 But ANCA wont completely replace it. (depends on scenario) --Dr Langford https://t.co/rygxJ2EVFR

L rheumarhyme ( View Tweet)

Apr 04, 2019

Do female vs. male patients with AS #spondyloarthritis present differently? Dr Husni #RNL2019 https://t.co/ZEGuRzxGUn

MedR #QuedateEnCasa MedReuma ( View Tweet)

Apr 04, 2019

Dr Craig Leonardi's review of Effective biologics to achieve a PASI 100 in Psoriasis. The newer agents are far ahead! #RNL2019 https://t.co/p71hb58SAf

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