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Don't Blame the Weather in Sjogren's

d RheumNow

Seasonal variations in symptoms -- commonly reported by patients with rheumatic diseases -- were not observed in a large cohort of patients with primary Sjogren's syndrome, French investigators found.

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Folate Levels Protect from CV Mortality in RA

d Jack Cush, MD

In a study of rheumatoid arthritis (RA) patients, JAMA reports that serum folate level of greater than 4.3 ng/mL was associated with lower CV mortality risk.

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Interleukin-37 Targeting in Gout

d Jack Cush, MD

The Annals of Rheumatic Disease reports that interleukin- 27 (IL-37) may play an important role in the pathogenesis of gout, paving the way for future therapy with recombinant IL-37 in gouty arthritis.

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RheumNow Podcast- Methotrexate Mechanisms (2.28.20)

d Jack Cush, MD

Dr Jack Cush Reviews the news and journal articles from the past week on RheumNow.com

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45 SLE transverse myelitis pts compated to SLE neuromyelitis optica pts (NMO). SLE-TM frequently had fever, anticardiolipin Abs and lupus anticoagulant. NMO had lower incidence of rash, serositis, renal Dz less abnormal serologies (dsDNA, C3, Sm) https://t.co/JHN3b6qoKz

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Dr. John Cush RheumNow ( View Tweet)

Johnston County OA Project (1999–2015) found 327/800 with Xray hand OA (rHOA) - they were older, more often white and female. Women were more likely than men to have incident HOA, particularly for DIP rOA. HOA more frequent in whites vs AA https://t.co/wdXlrNqsIG

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Dr. John Cush RheumNow ( View Tweet)

Serum aldolase serves as a useful marker for diagnosis and assessment of disease activity in patients with adult-onset Still's disease. https://t.co/K1Z8uqLwML

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Dr. John Cush RheumNow ( View Tweet)

"There are a terrible lot of lies going about the world, and the worst of it is that half of them are true." - Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

CDC reports 16,000 deaths & 280,000 hospitalization from the2019-20 influenza. US Corona -just 2 deaths and 22 infected; means you should be 8000-100,000 times more worried about the FLU - NOT CORONA. Remember EBOLA, SARS, ZIKA - alot of press but no US IMPACT. Turn off your TV.

Dr. John Cush RheumNow ( View Tweet)

Todays QD Video https://t.co/k5D2xmRhRX is also a podcast https://t.co/HzlY18qoEN about what to do when noncompliance gives you a brain fog.

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Dr. John Cush RheumNow ( View Tweet)

RAPPORT registry studied 162 pts w/ RA & PsA w/ 234 pregnancies. 1/3 had fewer children than desired. 63 preg after Dx - 2/3 had good control during pregnancy but 3/4 flared w/in 3 mos postpartum; & 35% of pregnancies conceived on biologics https://t.co/Vg8OaRLfyt

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Dr. John Cush RheumNow ( View Tweet)

Vitamin D deficiency is associated with lumbar disc disease and LBP in postmenopausal women; moresoe w/ very low vitamin D concentration < 10 ng/mL - study of 232 postmenopausal women https://t.co/Kmu8nMOaf7

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Dr. John Cush RheumNow ( View Tweet)

U.S. FDA Accepts Regulatory Submission for Tanezumab, an NGF inhibitor, for the Treatment for Patients with Chronic Pain Due to Moderate-to-Severe Osteoarthritis https://t.co/9NsESTnn4S

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Dr. John Cush RheumNow ( View Tweet)

"He has all of the virtues I dislike and none of the vices I admire." -Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

QD Clinic - Cases, insights and RNL info. Listen to the podcasts on iTunes or here https://t.co/V60JN2ZdYF

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Dr. John Cush RheumNow ( View Tweet)

The RHeumNow Podcast is up. https://t.co/pD2fWDsCOJ Checkout the podcast >> https://t.co/x0RytGbNYi

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Dr. John Cush RheumNow ( View Tweet)

Long term safety of Sarilumab reviewed. 2887 SAR pts on Combo and 471 on SAR mono Rx for up to 7.3 yrs (8188 PYs). SAEs 9.4 & 6.7/100PY; SIE 3.7 &, H zoster (0.5-0.6/100PY), GI perforations < 0.1/100PY & Cancer 0.7-.6. ANC <1000 in 13-15% https://t.co/YA2TKCdpGY

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Dr. John Cush RheumNow ( View Tweet)

Study of metformin in NON-diabetics w/ inflammatory disease on Pred >20/d shows metformin to to reduce pneumonia, serious infections, markers of carbohydrate/lipid,/liver & bone metabolism (vs PBO) but had no effect on truncal fat https://t.co/8RE2fJMkv9

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Dr. John Cush RheumNow ( View Tweet)

Prof Dinesh Khanna has an algorithm for SSc ILD. High CRP is a risk. HRCT is only low radiation so use for dx and prognosis #CRA2020 great lecture @RheumNow @earlyarthritis @sclerodermaUM https://t.co/VgltxqFKCo
Janet Pope Janetbirdope ( View Tweet)
Syphilis = The great imitator! Dx further muddled by periods of active and inactive disease. 2 main diagnostic algorithms that rely on serology, and both have pitfalls! @LCalabreseDO @NEJM @HealioRheum https://t.co/PvIG8hX0Ht https://t.co/EFTBYhK8QF

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Cassandra Calabrese CCalabreseDO ( View Tweet)
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