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Senate Drills Drug Makers Over Price

d Jack Cush, MD

Reuters reported that today, the US Senate Finance Committee met to question the executives from seven US pharmaceutical companies on the rising price drugs in America. 

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Does Smoking Cessation Reduce RA Risk?

d RheumNow

Individuals who quit smoking and maintained their nonsmoking status over a long duration of time had a decreased risk of developing seropositive rheumatoid arthritis (RA), an analysis of two large prospective cohorts found. 

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Canadian Vaccination Guidelines for the Immunosuppressed

d Jack Cush, MD

A multidisciplinary Canadian task force has developed guidelines for vaccination in patients receiving immunosuppressive therapies, based on the evidence that immunosuppressive use in immune-mediated disease may be  associated with an elevated risk of infections. 

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FDA Slaps a Boxed Warning on Febuxostat for CV Risk

d Jack Cush, MD

The U.S. Food and Drug Administration (FDA) has reviewed data from the Cardiovascular Safety of Febuxostat and Allopurinol in Patients with Gout and Cardiovascular Morbidities (CARES) trial and concluded there is an increased risk of death with Uloric (febuxostat) compared with allopurinol, and has added this as a boxed warning to the drug’s product label.

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FDA approval of an oral colchicine Gloperba for Adult Gout Flares - is this really an advance? At what price? You dont need colchicine to manage most cases of gout -my opinion of course! https://t.co/YnPl4Qchjj

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Live - If you cant attend in Ft Worth - no worries! View for FREE streaming online to your laptop - the Best Meeting & Best Faculty. Virtually participate in Lectures, interactive sessions, Q&A panels Register for the online course here https://t.co/m22mZf6JFG

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Dr. John Cush RheumNow ( View Tweet)

Population cross sectional study from Israel analyzed 11,782 RA pts and 57,973 controls. Thyroid disease was increased in RA patients vs controls (16.0% v 11.7%, p < 0.001 HypoT4; OR = 1.42, 95% CI 1.34–1.50) and hyperthyroidism (OR = 1.26). https://t.co/f3UAeLOBGb

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Dr. John Cush RheumNow ( View Tweet)

Key features in distinguishing Adult onset Stills disease from Fever of unknown origin: Arthralgia, rash, sore throat, neutrophilia, ferritin >5xULN, LDH based on comparison study of 69 AOSD & 87 FUO pts. 3 or more fever peaks daily makes AOSD less likely. https://t.co/49X4GGludn

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Dr. John Cush RheumNow ( View Tweet)

Skin Findings of Dermatomyositis - a few here you may not know about including Holster sign, Psoriasiform changes in scalp, Gottrons sign & papules, heliotrope, Vneck shawl, periungual erythema, facial erythema, erythroderma, calcinosis. https://t.co/IKGSCQ04L1

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis of 18 studies shows individuals with mult-site pain have a higher future risk for FALLS (OR = 1.74 (95%CI 1.57–1.93)). For high-quality studies, multisite pain pts have double the odds of a future falls. https://t.co/lZLl8z7SMk

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Dr. John Cush RheumNow ( View Tweet)

Nurses Health Study had 1528 incident #RA cases. Current smoking increased risk of seropositive (not Seronegative) RA (HR 1.47). Smoking cessation >10, >20, >30 yrs ago assoc w/ decreasing risk of seropos. RA, but risk still remains > 30 yrs (HR 1.30) https://t.co/1CsIcXtJ1I

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Dr. John Cush RheumNow ( View Tweet)

Prospective cohort study of 93 Systemic sclerosis patients with ILD; 2/3 had diffuse SSc. Half had PH diagnosis w/in 7 yrs of SSc onset, 83% Rx with ILD therapy, 83% Rx for PH. Survival rate for SSc-ILD and PH at 3 years after PH diagnosis was 91%. https://t.co/ZmOmWutwxq

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Dr. John Cush RheumNow ( View Tweet)

8.9% of systemic sclerosis pts were ANCA+, denoting a subset with increased risk of ILD (44.8% vs 21.8%, p < 0.001) and pulmonary embolism (8.6% vs 3.0%) in SSc. ANCA should be tested in SSc, as it identifies individuals with worse prognosis https://t.co/WhlEpxFdIG

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic - New Changes to Gout Guidelines. Lessons from the clinic - a noncompliant gout patient needs to restart his gout drugs, what to do with febuxostat? https://t.co/XwaUewBjWS via @YouTube

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Dr. John Cush RheumNow ( View Tweet)

ERRATA: "How to Handle Latex Allergies and Biologics" - has been corrected to show that the Cimzia PFS DOES contain 7% of a plastic derived from natural rubber latex. Latex- sensitive patients should be advised to handle the needle shield with caution. https://t.co/ThLns4C5Jt

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Dr. John Cush RheumNow ( View Tweet)

Among 548 pts referred to academic pain center & treated for back pain, 42% met fibromyalgia criteria. FM+ pts were more likely to be younger, unemployed, w/ greater pain severity, more neuropathic pain, depression, anxiety & lower physical function https://t.co/gse5CDnJ13

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Dr. John Cush RheumNow ( View Tweet)

Taiwanese insurance claims data study shows that Sjogrens syndrome patients (n=13398) have increased risk of osteonecrosis of jaw compared to 54K controls (0.08%vs0.03%, p=0.017) & also bisphosphonate ONJ (adjusted HR=7.9, p<0.001). https://t.co/qQSV16muNN

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Dr. John Cush RheumNow ( View Tweet)

JAMA reports from 2005-2015 PCP density in USA decreased from 46.6 to 41.4 per 100 000, with greater losses in rural areas. Every 10 PCP increase per 100K was assoc w/ added 51 day survival; every 10 specialists per 100k correlated with 19d incr survival https://t.co/81TRwFzOnH

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Dr. John Cush RheumNow ( View Tweet)

The Johns Hopkins Myositis Center is proud to announce the launch of the Peter Frampton Myositis Research Fund. https://t.co/SAVf1AEdqO Join @peterframpton and our Myositis Center team as we work to improve the lives of those impacted by #myositis https://t.co/BjOOaHYuJq

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Johns Hopkins Rheumatology jhrheumatology ( View Tweet)
QD Clinic Week 6 Podcast - case based lessons from the real world. Discusion of Pregnancy Rules, Optimizing MTX, Changing DMARDs, Stopping Anakinra in Still's, NP decisions. Listen on iTUNES or Here https://t.co/61KO2jKxJp

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Dr. John Cush RheumNow ( View Tweet)

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