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New Treatments in Axial SpA from #ACR2019

d Antoni Chan, MD, PhD

There were new developments in the treatment of axial Spondyloarthritis (AS) at ACR 2019. The first area is on the use of anti-IL17A drugs, secukinumab and ixekizumab in non-radiographic AS. The second area is the use of JAK-1 inhibitor Upadacitinib in radiographic AS.

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RheumNow Podcast – ACR 2019 Round Up (11.15.19)

d Jack Cush, MD

Dr. Jack Cush presents his favorite abstracts and presentations from Rheumatology Round Up and ACR 2019.

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The FDA has approved Pfizers new adadliumab biosimilar - Abrilada (adalimumab-afzb), this is the 5th adalimumab biosimilar to be approved (none are commercially available in the USA until 2023). Abrilada is the 25th biosimilar approved in the U.S. https://t.co/Z0tp3D5yOd

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Dr. John Cush RheumNow ( View Tweet)

7-year, 5,179-patient ISCHEMIA study presented at the AHA Meeting shows that stents and CABG offer no advantage over medical management in prevention of death and cardiovascular events. https://t.co/Fk6kypcek9

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Dr. John Cush RheumNow ( View Tweet)

Hand OA responds to 10mg/d Pred over 6wks. As expected symptoms return on cessation Anecdotally, there are people who do well on pragmatic, long term low dose eg 5mg or less/d #ACR19 @rheumnow Abst1760 https://t.co/FtE9vHb655

Dr Irwin Lim _connectedcare ( View Tweet)
#ACR19 Rheumatology RoundUp - Kavanaughs Picks: 2505 PsA prevention 1366 Self Joint exams 1120 Rheum burnout 1310 OA Hx 565 Enteropathic arthritis Recs 1823 MRE dx of SI 2773 Machine learning 2772 Antiinflammatory diet in RA 1359 Synovial Bx

Dr. John Cush RheumNow ( View Tweet)

#ACR19 Rheumatology RoundUp - Cushs Abstract Picks: 1223 ALLN-346 Urate Degrading Enzyme L06 Emapalumab in MAS 1890 2357 MTX Safety 1240 anaGO 2292 2279 Biologic WD in Preg 633 631 AS Delays in Dx & referral 196 VTE & ASCVD 2566 Polypharmacy in SLE

Dr. John Cush RheumNow ( View Tweet)

CAPS is caused by mutations in NLRP3, a component of the inflammasome. It is thought that NLRP3 mutations lead to the uncontrolled production of the inflammatory cytokine IL-1b.

Jonathan Hausmann MD hausmannMD ( View Tweet)

Patients with more severe #CAPS phenotypes may develop hearing loss, amyloidosis, aseptic meningitis, intellectual impairment, or #arthritis.

Jonathan Hausmann MD hausmannMD ( View Tweet)

Holy Molly! TNFi (etanercept, adalimumab, infliximab, or golimumab) completely prevented stokes in patients with DADA2. #ACR19 @RheumNow

Jonathan Hausmann MD hausmannMD ( View Tweet)

"I usually do not" give methotrexate to men with RA who are trying to conceive. Dr. Bathon. "But methotrexate is in serum for brief periods, unlikely to affect semen, unlikely to affect pregnancy." Dr. Bykerk #ACR19 @RheumNow

Jonathan Hausmann MD hausmannMD ( View Tweet)

https://t.co/Zdx0syodMK

Jonathan Hausmann MD hausmannMD ( View Tweet)
Awesome to meet new people from across the globe, catch up with old friends, and discuss why #ACR20 should have abundant free food! https://t.co/lEdYZM9BHB

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Jonathan Hausmann MD hausmannMD ( View Tweet)

However, 15-30% of patients with acute pericarditis develop recurrent pericarditis

Jonathan Hausmann MD hausmannMD ( View Tweet)

Recurrent pericarditis (RP) is the recurrence of pericarditis after a more than 4-6 week symptom-free period. RP is typically treated with steroids, colchicine, NSAIDs. Nevertheless, RP is associated with a high burden of disease and there is an unmet need for better treatment.

Jonathan Hausmann MD hausmannMD ( View Tweet)

The highlight of the last day of #ACR19 is the Rheumatology Roundup Highlights #ACRBest by Drs. John Cush @RheumNow and Arthur Kavanaugh @ACRheum always worth attending with great take home messages #rheum https://t.co/eMdvc2byKG

Dr. Antoni Chan synovialjoints ( View Tweet)
Hope to have many more interdisciplinary discussions re. irAEs #ACR19 @LCalabreseDO @CCalabreseDO @EladSharonMD @DrJNaidoo @UmaThanaMD @lexmeara @drdavidliew https://t.co/8KDorKW2WJ

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Laura Cappelli cappelliMD ( View Tweet)

Great ACR 2019. We weathered the weather #ACR @RheumNow https://t.co/lCKxADudRf
Janet Pope Janetbirdope ( View Tweet)
Different centres have different yields from temporal artery biopsy independent of biopsy length #ACR19 @RheumNow Abs 2685 https://t.co/Gqy9sY4OrM
Philip Robinson philipcrobinson ( View Tweet)
Just took few pictures during social media gathering yesterday at #ACR19. It was so nice to meet everyone. Thanks to @psufka for organizing and it was nice to meet the man behind the legend! @Drbeckyg @maio_danila https://t.co/lSpPz0V4ng
Angelo Gaffo ALGaffoRheumMD ( View Tweet)
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